
Selected Publications
- Portillo, J.A., Muniz Feliciano, G. Okenka, L., F. Heinzel, M.C. Subauste and C.S. Subauste. CD40 and TNF-α synergize to induce nitric oxide synthase in macrophages. Immunology. In press.
- Subauste, C.S. Animal Models: Toxoplasma gondii. 2011. In Current Protocols in Immunology. J.E. Coligan, A. M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons, Inc. New York, NY. In press.
- Portillo, J.A., G. Okenka, E. Reed, A. Subauste, J. Van Grol, K. Gentil, M. Komatsu, K. Tanaka, G. Landreth, B. Levine and C.S. Subauste. 2010. The CD40-autophagy pathway is needed for host protection despite IFN-γ-dependent immunity and CD40 induces autophagy via control of p21 levels. PLoS One. 314472.
- Van Grol, J. M.C. Subauste, R.M. Andrade, K. Fujinaga, J. Nelson and C.S. Subauste. 2010. HIV-1 inhibits autophagy in bystander macrophages/monocytic cells through Src-Akt and STAT3. PLoS One. e11733.
- Portillo, J.A., G. Okenka, T.S. Kern and C.S. Subauste. Identification of primary retinal cells and ex vivo detection of pro-inflammatory molecules using flow cytometry. Mol. Vision. 15: 1383-1389.
- Portillo, J.A, J. Van Grol, L. Zheng, G. Okenka, A. Garland, K. Gentil, E. Carlson, T.S. Kern, and C.S. Subauste. 2008. CD40 mediates retinal inflammation and neuro-vascular degeneration. J. Immunol. 181: 8719-8726.
- Subauste, C.S., A. Subauste and M. Wessendarp.2007. Role of CD40-dependent downregulation of CD154 in impaired induction of CD154 in CD4+ T cells from HIV-1-infected patients. J. Immunol. 178:1645-1653.
- Subauste, C.S., R.M. Andrade, and M. Wessendarp. 2007. CD40-TRAF6 and autophagy-dependent macrophage anti-microbial activity. Autophagy. 3: 245-248.
- Andrade, R.M., M. Wessendarp. M.J. Gubbels, B. Striepen and C.S. Subauste. 2006. CD40 induces macrophage anti-microbial activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J. Clin. Invest. 116:2366-2377.
- Subauste, C.S. and M. Wessendarp. 2006. CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon. Infect. Immun. 74: 1573-1579.
- Andrade, R.M., J-A.C. Portillo, M. Wessendarp, J. Yang, and C.S. Subauste. 2005. TNF-receptor associated factor 6 dependent CD40 signaling CD40 primes macrophages to acquire antimicrobial activity in response to TNF-α. J. Immunol. 175: 6014-6021.
- Andrade, R.M., J-A.C. Portillo, M. Wessendarp and C.S. Subauste. 2005. CD40 signaling in macrophages induces anti-microbial activity against an intracellular pathogen independently of IFN-γ and reactive nitrogen intermediates. Infect. Immun. 73: 3135-3123.
- Carlos Subauste, M.D.
- Associate Professor of Medicine, Ophthalmology and Pathology
- Phone: (216) 368-2785
- Fax: (216) 368-2034
- Email: carlos.subauste@case.edu
- Education
- MD - Universidad Peruana Cayetano Heredia, 1983
- Residency and Chief Residency - Southern Illinois University, 1988
- Fellowship - Stanford University, 1992
- NIH Biosketch

