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Jones S, Chen WD, Diehl F,
Parmigiani G, Beernwinkel N, Antal T, Traulsen A, Nowark M, Siegel C,
Velculescu V, Kinzler K, Vogelstein B, Willis J, Markowitz SD.
Comparative lesion sequencing provides insights into tumor evolution.
Proc Natl Acad Sci U S A 105:4283-4288, 2008.[PubMed]
Daley D, Lewis S, Platzer P,
MacMillen M, Willis J, Elston RC, Markowitz S, Wiesner G. Identification
of susceptibility genes for cancer in a genome-wide scan: results from the
colon neoplasia sibling study. American Journal of Human Genetics 82:
732-736, 2008.[PubMed]
Biswas S, Trobridge P,
Romero-Gallo J, Billheimer D, Myeroff L, Willson JKV, Markowitz S, Grady W.
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer
arises from the cooperation of genomic instability and the clonal outgrowth
of transforming growth factor ß resistant cells. Genes Chromosomes and
Cancer 47: 95-106, 2008.[PubMed]
Grady WM, Parkin RK,
Mitchell PS, Lee JH, Kim YH, Tsuchiya KD, Washington MK, Paraskeva C,
Willson JKV, Kaz AM, Kroh EM, Bllen A, Fritz BR, Markowitz SD, Tewari M.
Epigenetic silencing of the intronic microRNA has-miR-342 and its host gene
EVL in colorectal cancer. Oncogene, in press.[PubMed]
Zhang X, Guo C, Chen Y,
Shulha H, Schnetz M, LaFramboise T, Bartels C, Markowitz S, Weng Z, Scacheri
P, Wang Z. Epitope tagging of endogenous proteins for genome-wide ChIP-chip
studies. Nature Methods 5:163-165, 2008.[PubMed]
Daley D, Morgan W, Lewis S,
Willis J, Elston RC, Markowitz SD, Wiesner GL. Is TGFBR1*6A a
susceptibility allele for nonsyndromic familial colorectal neoplasia?
Cancer Epidemiol Biomarkers Prev16(5):892-4, 2007.[PubMed]
Wood LD, Parsons DW, Jones
S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman
N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R,
Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M,
Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger
DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P,
Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. The
Genomic Landscapes of Human Breast and Colorectal Cancers. Science
318:1108-13, 2007.[PubMed]
Itzkowitz SH, Jandorf L,
Brand R, Rabeneck L, Schroy PC, 3rd, Sontag S, Johnson D, Skoletsky J,
Durkee K, Markowitz S, Shuber A. Improved Fecal DNA Test for Colorectal
Cancer Screening. Clin Gastroenterol Hepatol 5(1):111-117, 2007.[PubMed]
Kann L, Han J, Ahlquist D,
Levin T, Rex D, Whitney D, Markowitz S, Shuber A. Improved marker
combination for detection of de novo genetic variation and aberrant DNA in
colorectal neoplasia. Clin Chem 2006;52(12):2299-302. [PubMed]
Guda K, Natale L, Markowitz SD.
An improved method for staining cell colonies in clonogenic assays.
Cytotechnology. 2007 June 15. Original Article [SpringerLink]
Uncorrected Proof
Sjoblom T, Jones S, Wood LD,
Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N,
Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D,
Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH,
Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The
consensus coding sequences of human breast and colorectal cancers.
Science. 2006 Oct 13;314(5797):268-74. [PubMed]
Myung SJ, Rerko RM, Yan M,
Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G,
Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD.
Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon
tumorigenesis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. [PubMed]
Chen, WD, Han ZJ, Skoletsky J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A, Markowitz SD.
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst. 2005 Aug. 3; 97 (15):1124-32. [PubMed]
Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Markowitz S.
Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia. Oncogene. 2005 Jan 20; 24(4):724-31 [PubMed]
Xin B,
Platzer P, Fink SP, Reese L, Nosrati A, Willson JK,
Markowitz S. Colon cancer secreted protein-2
(CCSP-2), a novel candidate serological marker of colon
neoplasia. Oncogene. 2004 Dec. 06 [PubMed]
Yan M,
Rerko RM, Platzer P, Dawson D, Willis J, Tong M,
Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G,
Hensold J, Tai HH, Wilson K, Markowitz SD.
15-Hydroxyprostaglandin dehydorengase, a COX-2 oncogene
antagonist, is a TGF-b-induced
suppressor of human gastrointestinal cancers. Proc
Natl Acad Sci U S A. 2004 Dec 14; 101(50):17468-17473. [PubMed]
Weis SJ,
Metz JM, Coyle C, Hampshire M, Jones HA, Markowitz S,
Rustgi AK. Recruitment of patients into an
internet-based clinical trials database: the experience
of OncoLink and the National Colorectal Cancer Research
Alliance. J Clin Oncol. 2004 Dec 1; 22(23):4678-84.
[PubMed]
Friedman
JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD.
C8orf4 is a transforming growth factor B induced
transcript downregulated in metastatic colon cancer.
Int J Cancer. 2004 Aug 10; 111(1):72-5. [PubMed]
Coady MJ,
Chang MH, Charron FM, Platz C, Wallendorff B, Sah JF,
Markowitz SC, Romero MF, Lapointe JY. The human
tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate
cotransporter. J Physiol. 2004 Jun 15;
557(Pt3):719-31. [PubMed]
Ionov Y,
Nowak N, Perucho M, Markowitz S, Cowell JK.
Manipulation of nonsense mediated decay identifies gene
mutations in colon cancer cells with microsatellite
instability. Oncogene. 2004 Jan 22; 23(3):639-45. [PubMed]
Bardelli
A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD,
Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B.
PRL-3 expression in metastatic cancers. Clin Cancer
Res. 2003 Nov 15; 9(15):5607-15. [PubMed]
Wiesner
GL, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh
J, MacMillen M, Baliner B, Willis J, Elston RC,
Markowitz SD. A subset of familial colorectal
neoplasia kindreds linked to chromosome 9q22.2-31.2.
Proc Natl Acad Sci U S A. 2003 Oct 18; 100(22):12961-5.
[PubMed]
Li H,
Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi
L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J,
Willson JK, Plass C, Markowitz SD. SLC5A8, a sodium
transporter, is a tumor suppressor gene silenced by
methylation in human colon aberrant crypt foci and
cancers. Proc Natl Acad Sci U S A. 2003 Jul 8;
100(14):8412-7. [PubMed]
Grady
WM, Markowitz SD. Hereditary colon cancer genes.
Methods Mol Biol. 2003; 222:59-83. [PubMed]
Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E,
Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard
L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S.
PMEPA1, a transforming growth factor-beta-induced marker
of terminal colonocyte differentiation whose expression
is maintained in primary and metastatic colon cancer.
Cancer Res. 2003 Apr 1; 63(7):1568-75. [PubMed]
Fink S,
Mikkola D, Willson JK, Markowitz SD. TGF-beta-induced
nuclear localization of Smad2 and Smad3 in Smad4 null
cancer cell lines. Oncogene. 2003 Mar 6;
22(9):1317-23. [PubMed]
Traicoff
JL, Willson JK, Markowitz SD. Early loss of deleted
in colorectal carcinoma gene transcript detected in a
group of benign colon adenomas. J Biomed Sci. 2002
Nov-Dec; 9(6 Pt2):716-20. [PubMed]
Grady
WM, Markowitz SD. Genetic and epigenetic alterations
in colon cancer. Annu Rev Genomics Hum Genet. 2002;
3:101-28. [PubMed]
Markowitz SD, Dawson DM, Willis J, Willson JK. Focus
on colon cancer. Cancer Cell. 2002 Apr; 1(3):233-6.
[PubMed]
Moinova
HR, Chen WD, Shen L, Smiraglia D, Olechnowicz J, Ravi L,
Kasturi L, Myeroff L, Plass C, Parsons R, Minna J,
Willson JK, Green SB, Issa JP, Markowitz SD. HLTF
gene silencing in human colon cancer. Proc Natl
Acad Sci U S A. 2002 Apr 2; 99(7):4562-7. [PubMed]
Platzer
P, Upender MB, Wilson K, Willis J, Lutterbaugh J,
Nosrati A, Willson JK, Mack D, Ried T, Markowitz S.
Silence of chromosomal amplications in colon cancer.
Cancer Res. 2002 Feb 15; 62(4):1134-8. [PubMed]
Li H,
Myeroff L, Kasturi L, Krumroy L, Schwartz S, Willson JK,
Stanbridge E, Casey G, Markowitz S. Chromosomal
autonomy of hMLH1 methylation in colon cancer.
Oncogene. 2002 Feb 21; 21(9):1443-9. [PubMed]
Yan H,
Dobbie Z, Gruber SB, Markowitz S, Romans K, Giardiello
FM, Kinzler KW, Vogelstein B. Small changes in
expression affect predisposition to tumorigenesis.
Nat Genet. 2002 Jan; 30(1):25-6. [PubMed]
Wiesner
GL, Platzer P, Buxbaum S, Lewis S, MacMillen M,
Olechnowicz J, Willis J, Chakravarti A, Elston RC,
Markowitz SD. Testing for colon neoplasia
susceptibility variants at the human COX2 locus. J
Natl Cancer Inst. 2001 Apr 18; 93(8):635-9. [PubMed]
Grady
WM, Rajput A, Lutterbaugh JD, Markowitz SD. Detection
of aberrantly methylated hMLH1 promoter DNA in the serum
of patients with microsatellite unstable colon cancer.
Cancer Res. 2001 Feb 1;61(3):900-2. [PubMed]
Fink SP,
Swinler SE, Lutterbaugh JD, Massague J, Thiagalingam S,
Kinzler KW, Vogelstein B, Willson JK, Markowitz S.
Transforming growth fractor-beta-induced growth
inhibition in a Smad4 mutant colon adenoma cell line.
Cancer Res. 2001 Jan1; 61(1):256-60. [PubMed]
Markowitz S. DNA repair defects inactivate tumor
suppressor genes and induce hereditary and sporadic
colon cancers. J Clin Oncol. 2000 Nov 1; 18(21 Suppl):75S-80S.
[PubMed]
Ma AH,
Xia L, Littman SJ, Swinler S, Lader G, Polinkowvsky A,
Olechnowicz J, Kasturi L, Lutterbaugh J, Modrich P,
Veigl ML, Markowitz SD, Sedwick WD. Somatic mutation
of hPMS2 as a possible cause of sporadic human colon
cancer with microsatellite instability. Oncogene.
2000 Apr 27; 19(18):2249-56. [PubMed]
Chen WD,
Eshleman JR, Aminoshariae MR, Ma AH, Veloso N, Markowitz
SD, Sedwick WD, Veigl ML. Cytotoxicity and
mutagenicity of frameshift-inducing agent ICR191 in
mismatch repair-deficient colon cancer cells. J Natl
Cancer Inst. 2000 Mar 15; 92(6):480-5. [PubMed]
Markowitz S. TGF-beta receptors and DNA repair genes,
coupled targets in a pathway of human colon
carcinogenesis. Biochim Biophys Acta. 2000 Feb 14;
1470(1):M13-20. [PubMed]
Grady
WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S,
Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ,
KInzler KW, Vogelstein B, Willson JK, Markowitz S.
Mutational inactivation of transforming growth factor
beta receptor type II in microsatellite stable colon
cancers. Cancer Res. 1999 Jan 15; 59(2):320-4. [PubMed]
Grady
WM, Rajput A, Myeroff L, Liu DF, Kwon K, Willis J,
Markowitz S. Mutation of the type II transforming
growth factor-beta receptor is coincident with the
transformation of human colon adenomas to malignant
carcinomas. Cancer Res. 1998 Jul 15; 58(14):3101-4.
[PubMed]
Veigl
ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD,
Peryasamy S, Li GM, Drummond J, Modrich PL, Sedwick WD,
Markowitz SD. Biallelic inactivation of hMLH1 by
epigenetic gene silencing, a novel mechanism causing
human MSI cancers. Proc Natl Acad Sci U S A. 1998
Jul 21; 95(15):8698-702. [PubMed]
Eshleman
JR, Donover PS< Littman SJ, Swinler SE, Li GM,
Lutterbaugh JD, Willson JK, MOdrich P, Sedwick WD,
Markowitz SD, Veigl ML. Increased transversions in a
novel mutator colon cancer cell line. Oncogene. 1998
Mar5; 16(9):1125-30. [PubMed]
Phillips
WP Jr, Willson JK, Markowitz SD, Zborowska E, Zaidi NH,
Liu L, Gordon NH, Gerson SL. O6-methylguanine-DNA
methyltransferase (MGMT) transfectants of a
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive
colon cancer cell line selectively repopulate
heterogenous MGMT+/MEMGT- xenografts after BCNU and
O6-benzylguanine plus BCNU. Cancer Res. 1997 Nov 1;
57(21):4817-23. [PubMed]
Markowitz S. Atherosclerosis, just another cancer.
J. Clin. Invest. 1997 Nov 1; 100(9):2143-45. [PubMed]
Grady W,
Rajput A, Myeroff L, Markowitz S. What’s new with RII.
Gastroenterology. 1997 Jan; 112(1):297-302. [PubMed]
Liu L,
Markowitz S, Gerson SL. Mismatch repair mutations
override alkyltransferase in conferring resistance to
temozolomide but not to
1,3-bis(2-chloroethl)nitrosourea. Cancer Res. 1996
Dec 1; 56(23):5375-9. [PubMed]
Yang B,
Eshleman JR, Berger NA, Markowitz SD. Wild-type p53
protein potentiates cytotoxicity of therapeutic agents
in human colon cancer cells. Clin Cancer Res. 1996
Oct; 2(10):1649-57. [PubMed]
Yang B,
Stambrook PJ, Markowitz SD. Wild-type p53
demonstrates functional dominance in a human colon
carcinoma cell line in which it induces reversible
growth arrest. Clin Cancer Res. 1996 Oct;
2(10):1639-47. [PubMed]
Huang J,
Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ,
Wyllie AH, Zheng S, Willson JK, Markowitz SD, Morin P,
Kinzler KW, Vogelstein B, Dunlop MG. APC mutations in
colorectal tumors with mismatch repair deficiency.
Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9049-54. [PubMed]
Liu D,
Pearlman E, Diaconu E, Guo K, Mori H, Haqqi T, Markowitz
S, Willson J, Sy MS. Expression of hyaluronidase by
tumor cells in duces angiogenesis in vivo. Proc Natl
Acad Sci U S A. 1996 Jul 23; 93(15):7832-7. [PubMed]
Wang C,
Eshleman J, Lutterbaugh J, Bin Y, Willson, J, Markowitz
S. Spontaneous apoptosis in human colon tumor cell
lines and the relation of wt p53 to apoptosis. Chin
Med J (Engl) 1996 Jul; 109(7):537-41. [PubMed]
Markowitz SD, Roberts AB. Tumor suppressor activity
of the TGF-beta pathway in human cancers. Cytokine
Growth Factor Rev. 1996 Jun; 7(1):93-102. [PubMed]
Eshleman
JR, Markowitz SD, Donover PS, Lang EZ, Lutterbaugh JD,
Li GM, Longley M, Modrich P, Veigl ML, Sedwick WD.
Diverse hypermutability f multiple expressed sequence
motifs present in a cancer with microsatellite
instability. Oncogene 1996 Apr 4; 12(7):1425-32. [PubMed]
Brattain
MG, Markowitz SD, Willson JK. The type II
transforming growth factor-beta receptor as a
tumor-suppressor gene. Curr Opin Oncol. 1996 Jan;
8(1):49-53. [PubMed]
Wang CY,
Eshleman JR, Willson JK, Markowitz S. Both
transforming growth factor-beta and substrate release
are inducers of apoptosis in a human colon adenoma cell
line. Cancer Res. 1995 Nov 1; 55(21):5101-5. [PubMed]
Wang J,
Sun L, Myeroff L, Wang X, Gentry LE, Yang J, Liang J,
Zborowska E, Markowitz S, Willson JK, et al.
Demonstration that mutation of the type II transforming
growth factor beta receptor inactivates its tumor
suppressor activity in replication error-positive colon
carcinoma cells. J Biol Chem. 1995 Sep 15;
270(37):22044-9. [PubMed]
Markowitz S, Wang J, Myeroff L, Parsons R, Sun L,
Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW,
Vogelstein B, et al. Inactivation of the type II TGF-beta
receptor in colon cancer cells with microsatellite
instability. Science 1995 Jun 2; 268(5215):1336-8. [PubMed]
Eshleman
JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B,
Willson JK, Veigl ML, Sedwick WD, Markowitz SD.
Increased mutation rate at the hprt locus accompanies
microsatellite instability in colon cancer. Oncogene
1995 Jan 5; 10(1):33-7. [PubMed]
Markowitz SD, Myeroff L, Cooper MJ, Traicoff J, Kochera
M, Lutterbaugh J, Swiriduk M, Willson JK. A benign
cultured colon adenoma bears three genetically altered
colon cancer oncogenes, but progresses to tumorigenicity
and transforming growth factor-beta independence without
inactivating the p53 tumor suppressor gene. J Clin
Invest. 1994 Mar; 93(3):1005-13. [PubMed]
Smith
KJ, Johnson KA, Bryan TM, Hill DE, Markowitz S, Willson
JK, Paraskeva C, Petersen GM, Hamilton SR, Vogelstein B
, et al. The APC gene product in normal and tumor
cells. Proc Natl Acad Sci U S A. 1993 Apr 1;
90(7):2846-50. [PubMed]
Myeroff
LL, Markowitz SD. Increased nm23-H1 and nm23-H2
messenger RNA expression and absence of mutations in
colon carcinomas of low and high metastatic potential.
J Natl Cancer Inst. 1993 Jan 20; 85(2):147-52. [PubMed]
Markowitz S, Morabia A, Garibaldi K, Wynder E. Effect
of occupational and recreational activity on the risk of
colorectal cancer among males: a case-control study.
Int J Epidemiol. 1992 Dec; 21(6):1057-62. [PubMed]
Haut M,
Steeg PS, Willson JK, Markowitz SD. Induction of nm23
gene expression in human colonic neoplasms and equal
expression in colon tumors of high and low metastatic
potential. J Natl Cancer Inst. 1991 May 15;
83(10):712-6. [PubMed]
Baker SJ,
Markowitz S, Fearon ER, Willson JK, Vogelstein B.
Suppression of human colorectal carcinoma cell growth by
wild-type p53. Science 1990 Aug 24; 249(4971):912-5.
[PubMed]
Markowitz SD, Molkentin K, Gerbic C, Jackson J, Stellato
T, Willson JK. Growth stimulation by coexpression of
transforming growth factor-alpha and epidermal growth
factor-receptor in normal and adenomatous human colon
epithelium. J Clin Invest. 1990 Jul; 86(1):356-62. [PubMed]
Markowitz S, Haut M, Stellato T, Gerbic C, Molkentin K.
Expression of the ErbA-beta class of thyroid hormone
receptors is selectively lost in human colon carcinoma.
J Clin Invest. 1989 Nov; 84(5):1683-7. [PubMed] |
