TBRU Logo2Tuberculosis Research Unit (TBRU)

Integrating research to combat the global TB epidemic

TBRU Website

"This is a very exciting time in the fight against TB as politicians, public health officials, researchers, donor agencies, and foundations worldwide refocus their attention on the pandemic caused by the age-old pathogen Mycobacterium tuberculosis.

Multi-disciplinary research combining epidemiologic studies and clinical trials in TB endemic countries with modern microbiology, immunology, and genetics is essential to make progress in the fight against TB.

The NIH-funded Tuberculosis Research Unit (TBRU) is a leader in interdisciplinary TB research. The TBRU aims not only to understand how M. tuberculosis infects, persists, and causes disease in humans, but also to translate that understanding into improving prevention, vaccines, diagnostics, and drug treatment for TB."

- W. Henry Boom M.D., TBRU Director

Areas of Research

TBRU LogoMajor Focus: Tuberculosis
Research Types: Clinical Trials, Epidemiology, Immunology, Microbiology, Genetics, Virology

The TBRU functions as a multi-disciplinary, multi-national consortium of investigators and institutions in the United States, Europe and Africa, and is based and coordinated at Case Western Reserve University. The TBRU's aims and studies are focused around NIH/NIAID's Statement of Work. The TBRU brings together the expertise of microbiologists, immunologists, human geneticists, epidemiologists and experts in clinical trials for its studies. Descriptions of TBRU's research structure and work at current field and laboratory sites are described in more detail on the TBRU Research Structure page.

The TBRU has completed numerous clinical trials, epidemiologic and observational studies as well as smaller developmental projects all focused on addressing important questions, issues and controversies in the human response to M. tuberculosis exposure, infection and disease.  Our findings have largely been reported in the literature although a number of follow-up activities and completion studies have carried over or are being extended into current studies.

For more information, visit the TBRU Research page.

Associated Faculty

Associated faculty and their specializations (research, clinical, education, etc...). Small thumbnail images if possible. Link to main biographical page on organization's website. - A synopsis/summary of their involvment (1 paragraph or short list). Div struct - sparse placard style. titles(limit to within group)? Pubmed Link (search with argument)

  • Research Area: Tuberculosis
  • Research Focus: TB Immunology

The study of CD4+, CD8+ and gamma delta T cell responses to M. tuberculosis is the main interest of my laboratory. Specifically the role of mycobacterial lipoproteins and TLR receptors in regulating MHC-II antigen processing has become a major focus.

  • Research Area: Tuberculosis
  • Research Focus: Clinical Trials

Dr. Johnson's research interests have focused on phase I, II, and III IND and non-IND clinical trials of new drugs, immunotherapeutic agents and vaccines for the prevention and treatment of tuberculosis.

  • Research Area: Tuberculosis
  • Research Focus: Clinical Trials, Multi-drug resistant TB, Advocacy

Multi-Drug Resistant TB, HIV/AIDS.

  • Research Area: Tuberculosis
  • Research Focus: Genetic Epidemiology

Dr. Stein's research focuses on complex genetic disorders. Her primary research focus is in the study of genetic and environmental susceptibility to tuberculosis.

Education & Training Opportunities

Division of Infectious Diseases & HIV Medicine Fellowship Program

Infectious Diseases (ID) Fellowship Training is a 2-3 year program depending on the track the fellow chooses. The fellowship tracks are designed to meet all ACGME training requirements and 12 months of clinical experience and 24 months of continuity clinic experience for ABIM subspecialty board eligibility. The first year of training is highly concentrated on clinical training and includes 9 months of clinical service, one month of a Clinical Microbiology rotation, one month of an Ambulatory rotation and a ½ day per week continuity clinic. Years 2 and 3 allow protected time for research under the mentorship of a faculty advisor chosen by the fellow.

"Training in Geographic Medicine and Infectious Diseases" Training Grant (T32)

Candidates for T-32 support must be US citizens or permanent residents. This support is for postdoctoral trainees only, and there are no restrictions as to granted degree (Ph.D., M.D. or M.D./Ph.D.). Support will be for a minimum of 1 year with competitive renewal for years 2 and 3, dependent on annual review of scientific progress, objectives of the training plan and availability of training positions. The third year of support is not guaranteed. Trainees will be required to apply for outside sources of funding in their second year of training.

Contacts and Inquiries

Regular Mail:
Tuberculosis Research Unit
Case Western Reserve University
School of Medicine
10900 Euclid Ave., Room E202
Cleveland, OH 44106-4984

Visitors, Express Mail, and Deliveries:
Tuberculosis Research Unit
Case Western Reserve University
School of Medicine
2210 Circle Dr., Room E202
Cleveland, OH 44106-4984

Phone: (216) 368-1949
Fax: (216) 368-0105

General Inquiry Email: tbru@cwru.edu