←Return to Faculty Page

Carlos Subauste, M.D.

Associate Professor of Medicine, Ophthalmology and Pathology,
 Case Western Reserve University


Email : carlos.subauste@case.edu
Office Phone : 2216.368.2785
Fax : 216.368.2034
Lab : BRB 448A
Lab Website: Subauste Lab
Appointments : 216.844.7890
Outpatient Clinic : Special Immunology Unit

Education

  • M.D. : Universidad Peruana Cayetano Heredia, 1983
  • Residency : Internal Medicine, Southern Illinois University, 1984-1987
  • Chief Resident : Internal Medicine, Southern Illinois University, 1988
  • Fellowship, Infectious Diseases, Stanford University, 1988-1992

Research Interests

CD40 is a member of the TNF receptor superfamily that is expressed on a variety of hematopoietic and non-hematopoietic cells. CD40 is relevant to a broad array of diseases since CD40 is crucial for protection against many pathogens (Toxoplasma, Cryptosporydium, Mycobacteria, Salmonella, Cryptococcus, etc), and CD40 drives various diseases that have an inflammatory component (atherosclerosis, inflammatory bowel disease, systemic lupus erythematosus, ischemia, graft rejection, etc). Dr. Subauste's laboratory studies both aspects of CD40 biology with the hope of identifying new approaches for treatment of inflammatory disorders and infections controlled by CD40.

Selected References

  • Portillo, J.A., Muniz Feliciano, G. Okenka, L., F. Heinzel, M.C. Subauste and C.S. Subauste. CD40 and TNF-α synergize to induce nitric oxide synthase in macrophages. Immunology. In press.
  • Subauste, C.S. Animal Models: Toxoplasma gondii. 2011. In Current Protocols in Immunology. J.E. Coligan, A. M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons, Inc. New York, NY. In press.
  • Portillo, J.A., G. Okenka, E. Reed, A. Subauste, J. Van Grol, K. Gentil, M. Komatsu, K. Tanaka, G. Landreth, B. Levine and C.S. Subauste. 2010. The CD40-autophagy pathway is needed for host protection despite IFN-γ-dependent immunity and CD40 induces autophagy via control of p21 levels. PLoS One. 314472.
  • Van Grol, J. M.C. Subauste, R.M. Andrade, K. Fujinaga, J. Nelson and C.S. Subauste. 2010. HIV-1 inhibits autophagy in bystander macrophages/monocytic cells through Src-Akt and STAT3. PLoS One. e11733.
  • Portillo, J.A., G. Okenka, T.S. Kern and C.S. Subauste. Identification of primary retinal cells and ex vivo detection of pro-inflammatory molecules using flow cytometry. Mol. Vision. 15: 1383-1389.
  • Portillo, J.A, J. Van Grol, L. Zheng, G. Okenka, A. Garland, K. Gentil, E. Carlson, T.S. Kern, and C.S. Subauste. 2008. CD40 mediates retinal inflammation and neuro-vascular degeneration. J. Immunol. 181: 8719-8726.
  • Subauste, C.S., A. Subauste and M. Wessendarp.2007. Role of CD40-dependent downregulation of CD154 in impaired induction of CD154 in CD4+ T cells from HIV-1-infected patients. J. Immunol. 178:1645-1653.
  • Subauste, C.S., R.M. Andrade, and M. Wessendarp. 2007. CD40-TRAF6 and autophagy-dependent macrophage anti-microbial activity. Autophagy. 3: 245-248
  • Andrade, R.M., M. Wessendarp. M.J. Gubbels, B. Striepen and C.S. Subauste. 2006. CD40 induces macrophage anti-microbial activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J. Clin. Invest. 116:2366-2377.
  • Subauste, C.S. and M. Wessendarp. 2006. CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon. Infect. Immun. 74: 1573-1579.
  • Andrade, R.M., J-A.C. Portillo, M. Wessendarp, J. Yang, and C.S. Subauste. 2005. TNF-receptor associated factor 6 dependent CD40 signaling CD40 primes macrophages to acquire antimicrobial activity in response to TNF-α. J. Immunol. 175: 6014-6021.
  • Andrade, R.M., J-A.C. Portillo, M. Wessendarp and C.S. Subauste. 2005. CD40 signaling in macrophages induces anti-microbial activity against an intracellular pathogen independently of IFN-γ and reactive nitrogen intermediates. Infect. Immun. 73: 3135-3123.