←Return to Faculty Page

Marion J. Skalweit, M.D., Ph.D.

Associate Professor of Medicine and Biochemistry,
 Case Western Reserve University

Director, Infectious Diseases Clinic,
 Louis Stokes Cleveland VA Medical Center

Email : marion.skalweit@va.gov
Office Phone : 216.791.3800 ext4682
Lab Phone : 216.791.3800 ext4681
Fax : 216.229.2403
Office : Cleveland VA Medical Center 1E-435
Lab : Cleveland VA Medical Center K109


  • B.S. : Chemistry, Case Western Reserve University, 1979-1983
  • Ph.D. : Chemistry, University of California at Berkeley, 1989
  • M.D. : Case Western Reserve University, 1992-1996
  • Residency : Internal Medicine, MetroHealth Medical Center, 1996-1999
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1999-2002

Research Interests

My laboratory is interested in resistance to beta-lactam antibiotics and beta-lactamase inhibitors caused by a wide variety of beta-lactamase enzymes such as Class A beta-lactamases (SHV of Klebsiella pneumoniae; TEM of E. coli); Class C beta-lactamases (CMY-2 enzyme) and Class B metallo-beta-lactamases (VIM-2 of Pseudomonas aeruginosa). In addition, we are studying the basis of sulbactam as an antibiotic for Acinetobacter baumannii and the role of metallo-beta-lactamase like enzymes in biofilm formation by a variety of bacteria. We are also developing a novel agent, Bulgecin A, to restore beta-lactam susceptibility in multi-drug resistant Gram negative bacteria. We employ a variety of microbiologic, molecular biologic, epidemiologic and biophysical methods to study resistance phenomena where they occur in the hospital and the laboratory. Through the outpatient ID clinic at the Cleveland VA, we also work in quality improvement and implementation science in areas of antimicrobial stewardship and HIV primary care with our ID fellows.

Selected References