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Scott Sieg, Ph.D.

Associate Professor of Medicine, Case Western Reserve University

Director, Immune Function Core Lab, Center for AIDS Research

Division of Infectious Diseases & HIV Medicine


Email : sfs2@case.edu
Office Phone : 216.368.6594

Education

  • B.S. : Biology, LaRoche College, 1983-1987
  • M.S. : Biology, Duquesne University, 1987-1989
  • Ph.D. : Immunology, Case Western Reserve University, 1993-1996

Research Interests

Human beta defensin-3 (hBD-3) is an antimicrobial peptide that is produced at epithelial surfaces. This molecule kills certain microbes as a component of innate defense mechanisms. HBD-3 also has chemotactic properties as well as the ability to activate antigen-presenting cells. One component of my research is centered on understanding how hBD-3 interacts with antigen-presenting cells and how it may serve as a bridge between innate and adaptive defense mechanisms.

Another project centers on the cytokine, interleukin-7 (IL-7). IL-7 is a critical cytokine in T cell homeostasis and survival. Recent clinical trials suggest that administration of IL-7 in HIV-infected persons can boost T cell reconstitution. We are investigating IL-7 responsiveness in HIV disease and also the effects of IL-7 on T cell function.

Additional projects in my lab include studies of HIV pathogenesis and immune dysfunction, immune reconstitution in HIV disease and IL-7 delivery.

Selected References

  • Rodriguez, B., D.A. Bazdar, N. Funderburg, R. Asaad, A.A. Luciano, G. Yadavalli, R.C. Kalayjian, M.M. Lederman and S.F. Sieg. 2011. Frequencies of FoxP3+ naïve T cells are related to both viral load and naïve T cell proliferation responses in HIV disease. J. Leukocyte Biology, 90:621-8.
  • Yonkers, N.L., S.F. Sieg, B. Rodriguez and D.D. Anthony. 2011. Reduced naïve CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection. Journal of Infectious Diseases, 203:635-45.
  • Funderburg, N.T., J.K. Jadlowsky, M.M. Lederman, Z. Feng, A. Weinberg and S.F. Sieg. 2011. The Toll-like receptor 1/2 agonists Pam(3)CSK(4) and human -defensin-3 differentially induce interleukin-10 and nuclear factor-B signaling patterns in human monocytes. Immunology, 134:151-60.
  • Lederman, M.L., L. Calabrese, N.T. Funderburg, B. Clagett, K. Medvik, H.Bonilla, B. Gripshover, R.A. Salata, A. Taege, M, Lisgaris, G.A. McComsey, E.Kirchner, J. Baum, C.Shive, R.Asaad, R.C. Kalayjian, S.F. Sieg and B. Rodriguez. 2011. Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells. Journal of Infectious Diseases, 204: 1217-1226.
  • Bazdar, D.A., M. Kalinowska and S.F. Sieg. 2009. Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging. 2009. Journal of Infectious Diseases, 199:1019.
  • Funderburg, N., A. Weinberg, Z. Feng, M.M. Lederman and S.F. Sieg. 2007. Human β defensin-3 activates antigen-presenting cells via Toll-like receptors1 and 2. Proceedings of the National Academy of Science, USA. 104:18631.