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Miguel Quiñones-Mateu, Ph.D.

Adjunct Professor, Case Western Reserve University

Division of Infectious Diseases & HIV Medicine


Email : meq@case.edu
Office Phone : (216) 286-4283
Lab : (216) 286-4285

Education

  • B.S. : Biology, Universidad Central de Venezuela (Caracas, Venezuela), 1990
  • Ph.D. : Molecular Biology, Universidad Autonoma de Madrid (Madrid, Spain), 1996
  • Postdoctoral Fellowship. : Molecular Virology, Case Western Reserve University, 2000

Research Interests

Dr. Quiñones-Mateu's research focuses on viral evolution to answer both basic and clinical questions related to (i) study the mechanisms, prevalence, and clinical consequences of drug resistant viruses and (ii) develop novel strategies to prevent the transmission and/or block the replication of pathogenic viruses.

Selected References

  • Archer, J., Weber, J., Henry, K., Winner, D., Gibson, R., Lee, L., Paxinos, E., Arts, E.J., Robertson, D.L., Mimms, L., and Quiñones-Mateu M.E. (2012). Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism. PLoS ONE, 7:e49602
  • Quiñones-Mateu M.E., and Vanham, G. (2012). HIV microbicides: where are we now?. Current HIV Research, 10:1-2
  • Selhorst P., Vazquez A.C., Terrazas-Aranda, K., Michiels, J., Vereecken, K., Heyndrickx, L., Weber, J., Quiñones-Mateu M.E., Arien, K.K., and Vanham, G. (2011). Human immunodeficiency virus type 1 (cross-) resistance to non-nucleoside reverse transcriptase inhibitors currently under development as microbicides. Antimicrobial Agents and Chemotherapy, 55:1403-1413
  • Jegede O., Khodyakova A., Chernov M., Weber, J., Menendez-Arias, L., Gudkov A., and Quiñones-Mateu M.E. (2011). Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system. Antiviral Research, 91:94-98
  • Weber, J., Vazquez, A.C, Winner, D. Rose, J.D., Wylie, D., Rhea, A., Henry, K., Pappas, J., Wright, A., Mohamed, N., Gibson, R., Rodriguez, B., Soriano, V., King, K., Arts, E.J., Olivo, P.D., and Quiñones-Mateu M.E. (2011). Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multi-target era of antiretroviral therapy. Antimicrobial Agents and Chemotherapy, 55:3729-3742
  • Weber J., Weberova J., Carobene M., Mirza M., Martinez-Picado J., Kazanjian P., and Quiñones-Mateu M.E. (2006). Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. Journal of Virological Methods, 136:102-117/li>
  • Quiñones-Mateu M.E., Lederman M.M., Feng Z., Chakraborty B., Weber J., Rangel H.R., Marotta M.L., Mirza M., Jiang B., Kiser P., Medvik K., Sieg S.F., and Weinberg A. (2003). Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication. AIDS, 17:F39-F48
  • Quiñones-Mateu M.E., Ball S.C., Marozsan A. J., Torre V. S., Albright J.L., Vanham G., van der Groen G., Colebunders R.L. & Arts E.J. (2000). A dual infection/competition assay shows a correlation between ex vivo HIV-1 fitness and disease progression. Journal of Virology, 74:9222-9233.