My basic research focuses on the mechanisms by which the normal intestinal microflora inhibit colonization by nosocomial pathogens. My clinical research focuses on the role of the intestinal tract as a source for transmission of nosocomial pathogens.
I am the Chairman of the Infection Control Committee at the Cleveland Veterans' Affairs Medical Center, and my research concerns lie predominantly within this subject area. I am interested in the role of intestinal colonization in the spread of resistant bacteria in hospital settings. My research is translational in nature and our laboratory currently has projects dealing with:
- Animal models of intestinal colonization and transmission
- Infection control and molecular epidemiology of MRSA and multidrug-resistant gram-negative rods
- Epidemiology and transmission of Clostridium difficile Infections in the elderly and in nursing home populations
- Infection control issues of antibiotic use and abuse Hand hygiene in the hospital