Education

• B.S. : Biology, Viterbo College , 1981-1985
• M.D. : Medical College of Wisconsin, 1986-1990
• Residency : Internal Medicine, Brown University, 1990-1993
• Chief Medical Residency, Brown University, 1993-1995
• Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1995-1999

Research Interests

My basic research focuses on the mechanisms by which the normal intestinal microflora inhibit colonization by nosocomial pathogens. My clinical research focuses on the role of the intestinal tract as a source for transmission of nosocomial pathogens.

I am the Chairman of the Infection Control Committee at the Cleveland Veterans' Affairs Medical Center, and my research concerns lie predominantly within this subject area. I am interested in the role of intestinal colonization in the spread of resistant bacteria in hospital settings. My research is translational in nature and our laboratory currently has projects dealing with:

• Animal models of intestinal colonization and transmission
• Infection control and molecular epidemiology of MRSA and multidrug-resistant gram-negative rods
• Epidemiology and transmission of Clostridium difficile Infections in the elderly and in nursing home populations
• Infection control issues of antibiotic use and abuse Hand hygiene in the hospital

Selected References

• Stiefel U, Cadnum JL, Eckstein BC, Guerrero DM, Tima MA, Donskey CJ. Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces versus skin of colonized patients. Infect Control Hosp Epidemiol 2011;32:185-7.
• Jury LA, Guerrero DM, Burant, Cadnum JL, Donskey CJ. Effectiveness of routine patient bathing to reduce the burden of spores on skin of patients with Clostridium difficile infection. Infect Control Hosp Epidemiol 2011;32:181-4.
• Jump RL, Pultz MJ, Kypriotakis G, Donskey CJ. Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production. Antimicrob Agents Chemother 2011;55:546-9.
• Nerandzic MM, Donskey CJ. Effect of ceftobiprole on growth of and toxin production by C. difficile in cecal contents of mice. Antimicrob Agents Chemother 2011;55:2174-7.
• Perez F, Pultz MJ, Endimiani E, Bonomo RA, Donskey CJ. Effect of antibiotic treatment on establishment and elimination of intestinal colonization with KPC-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother 2011;55:2585-9.
• Guerrero DM, Chou C, Nerandzic MM, Cadnum JL, Donskey CJ. Clinical and infection control implications of Clostridium difficile infection diagnosed by PCR but with negative enzyme immunoassay for toxin. Clin Infect Dis 2011;53:287-90.
• Guerrero DM, Michelle MM, Jury LA, Chang S, Jump RL, Donskey CJ. Clostridium difficile infection in a Department of Veterans Affairs long-term care facility. Infect Control Hosp Epidemiol 2011;32:513-15.
• Werner NL, Hecker MT, Sethi AK, Donskey CJ. Unnecessary use of fluoroquinolone antibiotics in hospitalized patients. BMC Infect Dis 2011;11:187.
• Dumford DM 3rd, Nerandzic MM, Chang S, Richmond MA, Donskey CJ. Epidemiology of Clostridium difficile and vancomycin-resistant Enterococcus colonization in patients on a spinal cord injury unit. J Spinal Cord Med 2011;34:22-7.
• Angulo S, Morales A, Danese S, Llacuna L, Masamunt MC, Pultz N, Cifone MG, DeSimone C, Delgado S, Vila J, Panes J, Donskey CJ, Fernandez-Checa JC, Fiocchi C, Sans M. Probiotic sonicates selectively induce mucosal immune cells apoptosis through generation via neutral sphingomyelinase. PLOS One 2011;6:316953.