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David H. Canaday, M.D.

Associate Professor of Medicine, Case Western Reserve University

Associate Director, Geriatric, Research, Education and Clinical Center
 (GRECC), Louis Stokes Cleveland VA Medical Center

Division of Infectious Diseases & HIV Medicine,
 University Hospitals Case Medical Center


Email : dxc44@case.edu
Office Phone : 216.368.8901
Lab Phone : 216.368.0344
Fax : 216.368.2034

Education

  • B.A : University of Pennsylvania , 1984-1988
  • M.D. : Washington University School of Medicine, 1988-1992
  • Residency : Internal Medicine, University of Minnesota, 1992-1995
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1995-1999

Research Interests

One focus of the lab is understanding the mechanisms of increased pathogenesis during HIV/TB co infection specifically involving properties of macrophages and dendritic cells.

The second focus determining defects in the human immune system that occur with aging. Specifically we are trying to determine predictors of influenza and shingles vaccination failure in older adults.

Selected References

  • Canaday DH, Ziebold C, Noss E, Chervenak KA, Harding CV, Boom WH. Activation of human CD8+ ab+ TCR+ T cells by M. tuberculosis via an alternate class I MHC antigen processing pathway. Journal of Immunology. 162:372-9, 1999.
  • Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. Journal of Immunological Methods. 281: 129-142, 2003.
  • Zhou D, Li P, Lin Y, Lott JM, Canaday DH, Brutkiewicz RR, Blum JS. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity. 22:571-81, 2005.
  • Jones LJ, McDonald DM, Canaday DH. Rapid MHC-II antigen presentation of HIV-1 by dendritic cells. AIDS research and Human Retroviruses. AIDS Res Hum Retroviruses. 23:812-6. 2007.
  • Canaday DH, Amponsah NA, Jones L, Tisch DJ. Hornick TR, Ramachandra L. Influenza-induced production of interferon-alpha is defective in geriatric individuals. J. Clin. Immunol. 2010. May;30(3):373-83.
  • Reuter M, Canaday DH, McDonald D. Mycobacterium tuberculosis promotes HIV trans-infection and suppresses antigen processing by dendritic cells. Journal of Virology, 84:8549-60. 2010. PMCID: PMC2919047
  • El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH*. Polyfunctional M. tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis. 91:224-30. 2011.
  • Bartley M, Canaday DH. T cell hybridomas to study MHC-II restricted B-cell receptor-mediated antigen presentation by human B cells. Journal of Immunological Methods. 370: 35–42. 2011.
  • Lee JB, Oelke M, Ramachandra L, Canaday DH, Jonathan P. Schneck. Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors. Immunity and Ageing. 2011 Aug 16;8(1):6.
  • Clark HL, Banks, R, Jones L, Hornick TR, Higgins PA, Burant C, Canaday DH. Characterization of MHC-II antigen presentation by B cells and monocytes from older individuals. Clinical Immunology. 2012 Aug;144(2):172-7.
  • Chiu Y, Liang Shan L, Huang H, Haupt C, Bessell C, Canaday DH, Hao Zhang H, Ho Y, Powell JD, Mathias Oelke M, Margolick JB, Blankson JN, Griffin DE, Schneck JP. Identification of Sprouty-2 as a novel regulator of HIV-specific T cell polyfunctionality. Journal of Clinical Investigation. 2014 Jan 2;124(1):198-208.
  • Herati RS, Reuter MA, Dolfi DV, Mansfiel KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH*, Wherry EJ. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. Journal of Immunology, 2014, Oct 1;193(7):3528-3.
  • Van Epps P, Matining RM, Tassiopoulos K, Anthony DD, Landay A, Kalayjian RC, Canaday DH. Older Age is Associated with peripheral blood expansion of Naïve B cells in HIV-infected Subjects on Antiretroviral Therapy. PLoS One. 2014 Sep 10;9(9):e107064.
  • Van Epps P, Banks R, Aung H, Betts MR, Canaday DH. Age-related differences in polyfunctional T cell Responses. Immunity & Ageing. 2014 Oct 23;11:14. doi: 10.1186/1742-4933-11-14. eCollection 2014.
  • Canaday DH, Sridaran S, Van Epps P, Aung H, Burant CJ, Nserko M, Mayanja-Kizza H, Betts MR, Toossi Z. CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection. Tuberculosis, 2015, in press.
  • Van Epps P, Sridaran S, Aung H, Wilson B, Burant CJ, Nsereko M, Mayanja-Kizza H, Betts MR, Toossi Z, Canaday DH. CD4 T cell cytokine correlates of diagnostic tests for latent TB in HIV-1-infected subjects. International Journal of Tuberculosis and Lung Disease, 2015 in press.
  • * shared senior author