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David H. Canaday, M.D.

Associate Professor of Medicine, Case Western Reserve University

Associate Director, Geriatric, Research, Education and Clinical Center
 (GRECC), Louis Stokes Cleveland VA Medical Center

Division of Infectious Diseases & HIV Medicine,
 University Hospitals Case Medical Center


Email : dxc44@case.edu
Office Phone : 216.368.8901
Lab Phone : 216.368.0344
Fax : 216.368.2034

Education

  • B.A : University of Pennsylvania , 1984-1988
  • M.D. : Washington University School of Medicine, 1988-1992
  • Residency : Internal Medicine, University of Minnesota, 1992-1995
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1995-1999

Research Interests

One focus of the lab is understanding the mechanisms of increased pathogenesis during HIV/TB co infection specifically involving properties of macrophages and dendritic cells.

The second focus determining defects in the human immune system that occur with aging. Specifically we are trying to determine predictors of influenza and shingles vaccination failure in older adults.

Selected References

  • Jones LJ, McDonald DM, Canaday DH. Rapid MHC-II antigen presentation of HIV-1 by dendritic cells. AIDS research and Human Retroviruses. AIDS Res Hum Retroviruses. 23:812-6. 2007.
  • Canaday DH, Wu M, Lu S, Aung H, Peters P, Baseke J, Mackay W, Mayanja-Kizza H, and Toossi Z. Induction of HIV-1 expression correlates with T-cell responsiveness to mycobacteria in patients co-infected with HIV-1 and M. tuberculosis. AIDS Res Hum Retroviruses, 25: 213-216. 2009.
  • Canaday DH, Amponsah NA, Jones L, Tisch DJ. Hornick TR, Ramachandra L. Influenza-induced production of interferon-alpha is defective in geriatric individuals. Journal of Clinical Immunology. 30:373-83. 2010.
  • Reuter M, Canaday DH, McDonald D. Mycobacterium tuberculosis promotes HIV trans-infection and suppresses antigen processing by dendritic cells. Journal of Virology, 84(17):8549-60. 2010.
  • Canaday DH, Burant C, Jones L, Aung H, Woc-Colburn L, Anthony A. Antigen processing and presentation preserved in myeloid dendritic cells and monocytes from HCV-infected individuals. Cellular Immunology. 266:187-91. 2011.
  • El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH. Polyfunctional M. tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis. 91:224-30. 2011.
  • Bartley M, Canaday DH. T cell hybridomas to study MHC-II restricted B-cell receptor-mediated antigen presentation by human B cells. Journal of Immunological Methods. 370: 35–42. 2011.
  • Lee JB, Oelke M, Ramachandra L, Canaday DH, Jonathan P. Schneck. Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors. Immunity and Ageing. 2011 Aug 16;8(1):6.