Education

• B.S. : Microbiology and Immunology, University of Western Ontario, 1986-1990
• PhD.: Microbiology and Immunology, McGill University, 1990-1994
• Post doctoral Fellowship: Molecular Virology &Biochemistry, Case Western Reserve University, 1994-1997

Research Interests

Heterogeneity of human immunodeficiency virus type 1 (HIV- 1) has a significant impact on viral fitness, disease progression in the patient, emergence of drug resistance, and development of an effective vaccine. Although encompassing a broad range of topics, all of our research projects are related to HIV-1 genetic diversity.

Selected References

• Weber J, Vazquez AC, Winner D, Rose JD, Wylie D, Rhea AM, Henry K, Pappas J, Wright A, Mohamed N, Gibson R, Rodriguez B, Soriano V, King K, Arts EJ, Olivo PD, Quiñones-Mateu ME. Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful took in the multitarget era of antiretroviral therapy. Antimicrob Agents Chemother 2011 55:3729-42. PMID: 21628544.
• Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cycle Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA. PLoS Pathog. 2011 May;7(5):e1002038. Epub 2011 May 19. PMID:2162557.
• Lobritz MA, Lassen KG, Arts EJ. Lassen KG, Arts EJ. HIV-1 replicative fitness in elite controllers. Curr Opin HIV AIDS. 2011 May;6(3)214-20. PMID: 21430530 (PubMed – in process)
• Gao Y, Abreha M, Nelson KN, Baird H, Dudley DM, Abrah A, Arts EJ. Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific SiRNAS. Retrovirology. 2011 Jan 13;8 (1):5. PMID: 21232148 (PubMed – indexed for MEDLINE).
• Tebit, DM, Arts EJ. Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease. Lancet Infect Dis. 2011 Jan, 11(1);45-46 Epub2010 Dec 2 Review. PMID:21126914 (PubMed – indexed for MEDLINE).
• La Lalonde MS, Arts EJ. DNA suspension arrays; silencing discrete artifacts for high-sensitivity applications PLoS One, 2011 Nov 8:5 (11);e15476. PMID: 21079742 (PubMed – indexed for MEDLINE).
• Tebit DM, Lobritz M, Lalonde M, Immonen T, Singh K, Sarafianos S, Herchenroder O, Krausslich HG, Arts EJ. Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness and sensitivity to nonnucleoside RT inhibitors. J Virol 2010 84:9817-30. PMID: 20631150.