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THE CASE INTEGRATIVE CANCER BIOLOGY PROGRAM (ICBP)

 
 
A systems biology approach towards understanding the involvement of BER in the processing of IUdR Mohammad Azhar Aziz

Mohammad Azhar Aziz, PhD

Research Associate


Research Interests

1.A mathematical model of MED1 initiated BER activity on IUdR generated mispairs

2.Characterization & significance of Interaction between MED1 and MMR component(s)

3.Development of a quantitative in vivo assay for monitoring BER activity in mammalian cells

Educational background

Ph.D. Jawaharlal Nehru University, New Delhi, INDIA 2004 Biotechnology
M.Sc. Aligarh Muslim University, Aligarh, INDIA 1998 Biotechnology
B.Sc. Lucknow University, Lucknow, INDIA 1995 Botany & Chemistry

Selected peer-reviewed publications (in chronological order)

1. Midha S, Mishra R, Aziz MA, Sharma M, Mishra A, Khandelwal P and Bhatnagar R Cloning, expression, and characterization of recombinant nitric oxide synthase-like protein from Bacillus anthracis Biochem Biophys Res Comm. 2005 Oct 14;336(1):346-56 Abstract

2. Aziz MA, Sikriwal D, Singh S,Jarugula S, Kumar PA, Bhatnagar R Biolistic transformation of tobacco plastids with pagA gene to achieve multifold expression levels of anthrax protective antigen FASEB J.2005 Jul 19 Abstract

3. Singh S, Singh A, Aziz MA, Waheed SM, Bhat R, and Bhatnagar R Thermal inactivation of Protective Antigen of B. anthracis and its prevention by polyol osmolytes Biochem Biophys Res Commun. 2004; 322(3):1029-37 Abstract

4. Singh S, Aziz MA, Khandelwal P, Bhat R and Bhatnagar R The osmoprotectants glycine and its methyl derivatives prevent the thermal inactivation of protective antigen of Bacillus anthracis Biochem Biophys Res Commun. 2004; 316(2): 559-564 Abstract

5. Aziz MA, Singh S, Kumar PA, Bhatnagar R Expression of protective antigen in transgenic plants: A step towards edible vaccine against anthrax Biochem Biophys Res Commun. 2002 Dec 6;299(3):345-51 Abstract

6. Tayyab S, Haq SK, Sabeeha, Aziz MA, Khan MM, Muzammil S Effect Of lysine modification on conformation and Indomethacin binding properties of human serum albumin International Journal Of Biological Macromolecules 1999 26 :173-180 Abstract

For complete CV please click here

Contact Information

Mohammad Azhar Aziz ,PhD

Case Western Reserve University School of Medicine

2109 Adelbert Road, Cleveland,OH 44106

Phone:216-368-5034

maa32@case.edu