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Dennis Orthopaedics Tissue Engineering Laboratory

 
 

Publications

2008

Weidenbecher M, Tucker HM, Awadallah A, Dennis JE (2008) Fabrication of a Neotrachea Using Engineered Cartilage. Laryngoscope Jan 14 [Epub ahead of print] Abstract

 

T. Kean, M. Thanou, Invited book chapter on Chitin and Chitosan in Polymeric Biomaterials - In Press

 

I. K. Ko, M. Murakami, Karen Moodie, M. Simons, J.D. Pearlman. Visible Genetics (VisGen): A New Dual Modality Contrast Agent for Quantitative Assessment of Up-regulated Gene Product Distribution. Accepted in Magnetic Resonance in Medicine

 

2007

Dennis JE, Esterly K, Awadallah A, Parrish CR, Poynter GM, Goltry KL (2007) Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration. Stem Cells 25(10):2575-82 Abstract

 

Chen X, Song IH, Dennis JE, Greenfield EM (2007) Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts. J Bone Miner Res. 22(5):656-64 Abstract

 

Love, Z., Wang, F, Dennis, J, Awadallah, A, Salem, N, Lin, Y, Weisenberger, A., Majewski, S., Gerson, S, Lee, Z (2007) Imaging of mesenchymal stem cell transplant by bioluminescence and PET. J Nucl Med 48:2011-2020. Abstract

 

Henderson, J. H., Welter, J. F., Mansour, J. M., Niyibizi, C., Caplan, A. I., and Dennis, J. E. (2007) Cartilage tissue engineering for
laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Eng, 13(4):843-53. Abstract

 

Henderson, J. H., de la Fuente, L., Romero, D., Colnot, C. I., Huang, S., Carter, D. R., and Helms, J. A. Rapid growth of cartilage rudiments may generate perichondrial structures by mechanical induction. Biomech Model Mechanobiol, in press. DOI: 10.1007/s10237-006-0038-x. Abstract

 

Weidenbecher M, Henderson JH, Tucker HM, Baskin JZ, Awadallah A, Dennis JE. Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction. Laryngoscope. 2007 Oct;117(10):1745-9. Schick B, Weidenbecher M, Miller R, Iro H. Abstract


Experience with laryngotracheal reconstruction in subglottic stenosis in a 30years time period Laryngorhinootologie. 2007 May;86(5):358-64. Epub 2007 Jan 16. Weidenbecher M Jr, Weidenbecher M, Iro H. Abstract


Segmental tracheal resection for the treatment of tracheal stenoses HNO. 2007 Jan;55(1):21-8. German. Weidenbecher M, Schick B, Iro H. Abstract

 

I.K. Ko, H.T. Song, E.J. Cho, Y.M. Huh, J.S. Suh. In vivo MR imaging of tissue-engineered Human Mesenchymal Stem Cells Transplanted to the Mouse-Preliminary study. Annals of Biomedical Engineering, 35(1):101-108 (2007). Abstract

 

M. Nakajima, T. Ishimuro, K. Kato, I.K.Ko, I. Hirata, Y. Arima, H. Iwata. Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation. Biomaterials, 28(6), 1048-1060 (2007). Abstract

2006

Caplan, A. I. and Dennis, J. E. (2006) Mesenchymal stem cells as trophic mediators. J Cellular Biochem 98:1076-1084. Abstract

 

T. Kean, J. H. McB. Miller, G.G. Skellern, D. Snodin, Acceptance Criteria for Levels of Hydrazine in Substances for Pharmaceutical Use and Analytical Methods for its Determination, Pharmeuropa Scientific Notes, (2006) Abstract

 

T. Kean, Development of a synthetic uPAR targeted gene delivery system (2006) PhD Thesis, Cardiff University

 

[Styloid syndrome and its treatment] Laryngorhinootologie. 2006 Mar;85(3):184-90. Weidenbecher M, Huk WJ, Iro H. Abstract

 

2005

Bing, M, Hankenson, K.D., Dennis, J.E., Caplan, A.I., Goldstein, S.A., Kilbourne, M.R. (2005) A simple method for stem cell labeling with fluorine 18. Nucl. Med. Biol. 32:701-705. Abstract

 

Henderson, J. H., Chang, L. Y., Song, H. M., Longaker, M. T., and Carter, D. R. Age-dependent properties and quasi-static strains in the rat sagittal suture. J Biomechanics, 38:2294–2301, 2005. Abstract

 

Henderson, J. H., Nacamuli, R. P., Zhao, B., Longaker, M. T., and Carter, D. R. Age-dependent residual tensile strains are present in the dura mater of rats. J R Soc Interface, 2:159–167, 2005. Abstract

 

Internal carotid artery injury during functional endoscopic sinus surgery and its management. Eur Arch Otorhinolaryngol. 2005 Aug;262(8):640-5. Epub 2005 Jan 19. Weidenbecher M, Amann K, Iro H. Abstract

 

T. Kean, S. Roth, M. Thanou, Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency. J. Control. Release, 103(3) (2005) 643-53 Abstract

 

I.K. Ko, K. Kato, and H. Iwata. A Thin Carboxymethyl Cellulose Culture Substrate for the Cellulase-Induced Harvesting of an Endothelial Cell Sheet. Journal of Biomaterials Science, Polymer Edition. 16(10), 1277-1291 (2005). Abstract

 

I.K. Ko, K Kato, and H. Iwata. Parallel analysis of multiple surface markers expressed on rat neural stem cells using antibody microarrays, Biomaterials, 26, 4882-4891 (2005). Abstract


I.K. Ko, K Kato, and H. Iwata. Antibody microarray for correlation of cell phenotype with surface marker, Biomaterials, 26, 687-96 (2005). Abstract

 

A. El-salmawy, T Kitagawa, I.K. Ko, A. Murakami, Y. Kimura, T. Yamaoka, and H. Iwata. Preparation and properties of ProNectin F-coated biodegradable hollow fibers. J Artif Organs. 8 (4), 245-251 (2005). Abstract

 

S. Fujita, Y. Ueda, I.K. Ko, H. J. Paek, T. Sajiki, I. Ikai, Y. Yamaoka, Y.Ikada, and H. Iwata. Functional evaluation of bioartificial liver using RT-PCR. Bio-Medical Materials and Engineering, 15 (3), 211-218 (2005). Abstract

2004

Nishioka, K., Dennis, J.E., Gao, J., Goldberg, V. M., Caplan, A.I. (2004) Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. J. Cellular Physiol. 203:6-14. Abstract

 

Naumann, A., Dennis, J.E., Aigner, J., Coticchia, J., Arnold, J., Berghaus A., Kastenbauer, E.R., Caplan, A.I. (2004) Tissue Engineering Of Autologous Cartilage Grafts in Three Dimensional In Vitro Macro Aggregate Culture System. Tiss. Eng. 10: 1695-1706. Abstract

 

Dennis, J.E., Caplan, A.I. (2004) Advances in mesenchymal stem cell biology. Curr. Op. Orthop. 15:341-346. Abstract

 

Dennis, J.E., Cohen, N., Caplan, A. I., Goldberg, V.M. (2004) Targeted Delivery of Progenitor Cells for Cartilage Repair. J. Orthop. Res. 22:735-741. Abstract

 

Maitra, B., Szekely, E., Gjini, K., Laughlin, M.J., Dennis, J., Haynesworth, S. E., Koç, O.N. (2004) Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transpl. 33:597-604. Abstract

 

Henderson, J. H., Longaker, M. T., and Carter, D. R. Sutural bone deposition rate and strain magnitude during cranial development. Bone 34:271–280; 2004. Abstract

 

Paul Lin, Warren C. W. Chan, Stephen F. Badylak, Sangeeta N. Bhatia. Assessing Liver-Derived Biomatrix for Hepatic Tissue Engineering. Tissue Eng. 2004 Jul-Aug;10(7-8):1046-53. Abstract

 

T. Kean, S. Roth, M. Thanou, Trimethylation of chitosans: Its effect on toxicity and their application as a non-viral gene delivery system. In Journal of Pharmacy and Pharmacology, BPC Science abstracts (2004), Poster Session 2, #128 Abstract

 

T. Ohyama, I.K. Ko, A. Miura, H. Iwata, and W. Taki. ProNectin F-grafted-ethylene vinyl alcohol copolymer (EVAL) as a liquid type material for treating cerebral aneurysm. Biomaterials. 25(17), 3845-52 (2004). Abstract

pre 2004

Tallheden, T., Dennis, J. E., Lennon, D. P., Sjögren-Jansson, E., Caplan, A.I., Lindahl, A. (2003) Phenotypic plasticity of human articular chondrocytes. J. Bone Joint Surg. 85-A(Suppl.):93-99. Abstract

Yamashita, K., Dennis, J.E., Lennon, D. P., Norimoto, H., Kitamura, S., Caplan, A. I. (2003) Dental pulp cells with multi-potential for differentiation to odontoblast and chondroblast. J. Hard Tiss. Biol. 12:49-55.

Dennis, J.E., Caplan, A.I. (2003) Bone marrow mesenchymal stem cells. In: "Stem Cell Handbook", Humana Press, Inc., Totowa, N.J., Sell, S. (Ed.), pp. 107-117.

Dennis, J.E., Sochaga, L., Caplan, A.I. (2003) "Human Mesenchymal Stem Cells for Cartilage Repair., In: "Mesenchymal Stem Cells: Biology and Potential Clinical Uses", Ministerio De Sanidad Y Consumo, Madrid, Grisolía, S, Miñana, M.D., Bendala Tufanisco, E. (Eds.), p.p.157-168.

Laryngotracheal growth following cricotracheal resection combined with laminotomy. An experimental study on rabbits. Ann Otol Rhinol Laryngol. 2003 Aug;112(8):697-703. Sobiegalla M, von Hintzenstern U, Weidenbecher M Jr, Rupprecht H. Abstract

Tracheal rupture--a rare and dramatic emergency. Anaesthesiol Reanim. 2003;28(3):79-81. Sobiegalla M, von Hintzenstern U, Weidenbecher M Jr, Rupprecht H. Abstract

T.J. Kean, C.A. Jansma, G. Borchard, M. Thanou. Targeting The uPA Receptor Using Polymer-Ligand Conjugates For Non Viral Gene Delivery. in Proc. Int. Symp. Control. Release Bioact. Mater. 2003. Glasgow, UK

Y. Ueda, H. Iwata, H. J. Paek, I.K. Ko, Y. Shimooka, N. Katsura, I. Ikai, Y. Yamaoka, and Y. Ikada. Bioartificial liver with whole blood perfusion. ASAIO J, 49(4), 401-406 (2003). Abstract


Naumann, A., Dennis, J., Studenmaier, R, Totter, N., Aigner, J., Ziegelaar, B., Happ, T., Rasp, G., Caplan, A. I. (2002) Adulte mesenchymale stammzellen neue möglichkeiten der gewebezüchtung fur die plastich rekonstruktive chururgie. Laryngo Rhino Otologie 81:521-527. Abstract

Naumann, A., Dennis, J. E., Awadallah, A., Carrino, D. A., Mansour, J. M., Kastenbauer, E., Caplan, A I. (2002) Immunochemical and mechanical characterization of cartilage subtypes in rabbit. J. Histochem. Cytochem. 50:1049-1058. Abstract

Dennis, J. E., Charbord, P. (2002) Origin and differentiation of human and murine stroma. Stem Cells 20:205-214. Abstract

Gao, J., Dennis, J. E., Solchaga, L.A., Goldberg, V. M., Caplan, A. I. (2002) Repair of osteochondral defect with tissue engineered two phase composite material of injectable calcium phosphate and hyaluronan sponge. Tissue Eng 8:827-837. Abstract

Solchaga, L. A., Gao, J., Dennis, J. E., Awadallah, A., Lundberg, M., Caplan, A. I., Goldberg, V. M. (2002) Treatment of osteochondral defects with autologous bone marrow in a hyaluronan based delivery vehicle. Tissue Eng 8:333-347. Abstract

Henderson, J. H., and Carter, D. R. Mechanical induction in limb morphogenesis: the role of growth-generated strains and pressures. Bone 31:645–653; 2002. Abstract

Myun K. Han, Paul Lin, David Paek, John Harvey, Elena Fuior, and Jay R. Knutson. Fluorescence studies of Pyrene Maleimide-Labeled Translin: Excimer Fluorescence Indicates Subunits Associate in a Tail-to-Tail Configuration to Form Octamer. Biochemistry. 2002 Mar 12;41(10):3468-76 Abstract

I.K. Ko and H. Iwata. Simple methods to give cell attachment ability to biodegradable polyester. Annals of the New York Academy of Sciences. 961,288-291 (2002). Abstract

 

Dennis, J. E., Solchaga, L. A., Caplan, A. I. (2001) Mesenchymal stem cells for musculoskeletal tissue engineering. New Surg. 1:112-115.

Dennis, J. E., Carbillet, J. P., Caplan, A. I., Charbord, P. (2001) The STRO-1+ Marrow Cell Population Is Multipotential. Cells Tiss. Organs 170:73-82. Abstract

Gao, J., Dennis, J. E., Muzic, R. F., Lundberg, M., Caplan, A. I. (2001) The dynamic in vivo distribution of bone marrow derived mesenchymal stem cells after infusion. Cells Tiss. Organs 169:12-20. Abstract
I.K. Ko and H Iwata. An approach to constructing three-dimensional tissue. Annals of the New York Academy of Sciences. 944, 443-455 (2001). Abstract

 

Dennis, J. E., Carrino, D. A., Yamashita, K., Caplan, A. I. (2000) Monoclonal antibodies to mineralized matrix molecules of the avian eggshell. Matrix Biol. 19:683-692. Abstract

Solchaga, L. A., Yoo, J. U., Lundberg, J., Dennis, J. E., Huibregtse, B. A., Goldberg, V. M., Caplan, A. I. (2000) Hyaluronan based polymers in the treatment of osteochondral defects. J. Orthop. Res. 18:773-780. Abstract

Caplan, A. I., Dennis, J. E. (2000) Genetically linked scientists: The one two punch for NFATp knockout. J. Exp. Med. 191:1-3. Abstract

 

Remy Martin, J. P., Marandin, A., Challier, B., Bernard, G., Deschaseaux, M., Herve, P., Wei, Y., Tsuji, T., Auerbach, R., Dennis, J. E., Moore, K. A., Greenberger, J. S., Charbord, P. (1999) The vascular smooth muscle differentiation of murine stroma. A sequential model. Exp. Hematol. 27:1782-1795. Abstract

Solchaga, L. A., Yoo, J. U., Lundberg, J., Dennis, J. E., Huibregtse, B. A., Goldberg, V. M., Caplan, A. I. (1999) Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J. Orthop. Res. 17:205-213. Abstract

Dennis, J. E., Merriam, A., Awadallah, A., Yoo, J. U., Johnstone, B., Caplan, A. I. (1999) A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse. J. Bone Min. Res. 14:700-709. Abstract

 

Dennis, J. E., Konstantakos, M., Arm, D., Caplan, A. I. (1998) In vivo osteogenesis assay: A rapid method for quantitative analysis. Biomat. 19:1323-1328. Abstract

 

Allay, J. A., Dennis, J. E., Haynesworth, S. E., Majumdar, M. K., Clapp, D. W., Shultz, L. D., Caplan, A. I., Gerson, S. L. (1997) LacZ and interleukin 3 expression in vivo after retroviral transduction of marrow derived human osteogenic mesenchymal progenitors. Human Gene Therapy 8:1417-1427. Abstract

Velleman, S. G., McFarland, D. C., Li, Z., Ferrin, N. H., Whitmoyer, R., and Dennis, J. E. (1997) Alterations in sarcomere structure, collagen organization, mitochondrial activity, and protein metabolism in the avian low score normal muscle weakness. Dev. Growth Differ. 39:563-570. Abstract

Hanada, K., Dennis, J. E., and Caplan, A. I. (1997) Stimulatory effects of basic fibroblast growth factor (bFGF) and bone morphogenetic protein 2 (BMP) on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells (MSCs). J. Bone Min. Res. 12:1606-1614. Abstract

 

Caplan, A. I., Dennis, J. E. (1996) Mesenchymal stem cells: Progenitors, progeny and pathways. J. Bone Min. Metab. 14:193-201. Abstract

Cassiede, P., Dennis, J. E., Ma, F., and Caplan, A. I. (1996) Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGFb 1 of PDGF BB as assayed in vivo or in vitro. J. Bone Min. Res. 11:1-10. Abstract

Dennis, J. E., and Caplan, A.I. (1996) Analysis of the developmental potential of conditionally immortal marrow derived mesenchymal progenitor cells isolate from the H2Kb A58 transgenic mouse. Conn. Tissue Res. 35:93-99. Abstract

Dennis, J. E., and Caplan, A.I. (1996) Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse. J. Cellular Physiol. 167:523-538. Abstract

 

Dennis, J. E. (1995) Mesenchymal Progenitors in Adult Marrow. Ph. D. Thesis, Case Western Reserve University.

Dennis, J. E., Si Qun, S., Agarwal, M., Heuer, A., and Caplan, A.I. (1995) Microstructure of Matrix and Mineral Components of Eggshells From White Leghorn Chickens (Gallus gallus). J. Morph. 228:287-306. Abstract

Saito, T., Dennis, J. E., Lennon, D.P., Young, R. G., and Caplan, A.I. (1995) Myogenic Expression of Mesenchymal Stem Cells within Myotubes of mdx Mice In Vitro and In Vivo. Tissue Eng. 4:327-343.

Lennon, D.P., Haynesworth, S.E., Young, R.G., Dennis, J. E., and Caplan, A.I. (1995) A Chemically Defined Medium Supports Proliferation and Maintains Osteochondrogenic Potential of Rat Marrow Derived Mesenchymal Stem Cells. Exp. Cell Res. 219:211-222. Abstract

 

Carrino, D.A., Dennis, J. E., Drushel, R. F., Haynesworth, S.E., and Caplan, A.I. (1994) Identity of the Core Proteins of the Large Chondroitin Sulfate Proteoglycans Synthesized by Skeletal Muscle and Prechondrogenic Mesenchyme. Biochem. J. 298:51-60. Abstract

 

Dennis, J. E., and Caplan, A.I. (1993) Porous Ceramic Vehicles for Rat marrow derived (Rattus norvegicus) Osteogenic Cell Delivery: Effects of Pre treatment with Fibronectin or Laminin. Oral Implant. 19:106-115. Abstract

 

Dennis, J. E., Haynesworth, S.E., Young, R.G. and Caplan, A.I. (1992) Osteogenesis in Marrow Derived Mesenchymal Cell Porous Ceramic Composites Transplanted Subcutaneously: Effect of Fibronectin and Laminin on Cell Retention and Rate of Osteogenic Expression. Cell Transpl. 1:23-32. Abstract

Han, Y., Dennis, J. E., Cohen Gould, L., Bader, D.M. and Fischman, D.A. (1992) Expression of Sarcomeric Myosin in the Presumptive Myocardium of Chicken Embryos Occurs Within Six Hours of Myocyte Commitment. Dev. Dynam. 193:257-265. Abstract

Arias, J.L., Carrino, D.A., Fernandez, M.S., Rodriguez, J.P., Dennis, J. E., Caplan, A.I. (1992) Partial Biochemical and Immunochemical Characterization of Avian Eggshell Extracellular Matrices. Arch. Biochem. Biophys. 298:293-302. Abstract

 

Nakahara, H., Dennis, J. E., Bruder, S.P., Haynesworth, S.E., Lennon, D.P. and Caplan, A.I. (1991) In Vitro Differentiation of Bone and Hypertrophic Cartilage From Periosteal Derived Cells. Exp. Cell Res. 195:492-503. Abstract

Fernandez, M.S., Dennis, J. E., Drushel, R.F., Carrino, D.A. and Caplan, A.I. (1991) The Dynamics of Compartmentalization of Embryonic Muscle by Extracellular Matrix Molecules. Dev. Biol. 147:46-61. Abstract

Arias, J.L., Fernandez, M.S., Dennis, J. E. and Caplan, A.I. (1991) "The Fabrication and Collagenous Substructure of the Eggshell Membrane in the Isthmus of the Hen Oviduct." Matrix 11:313-320. Abstract

Arias, J.L., Fernandez, M.S., Dennis, J. E. and Caplan, A.I. (1991) "Collagens of the Chicken Eggshell Membranes." Conn. Tiss. Res. 26:37-45. Abstract

Saad, A.D., Dennis, J. E., Tan, I. and Fischman, D.A. (1991) Visualization of myosin exchange between synthetic thick filaments. J. Musc. Res. Cell Motil. 12:225-234. Abstract

Nanduri, J., Dennis, J. E., Rosenberry, T.L., Mahmoud, A.A.F. and Tartakoff, A.M. (1991) Glyocalyx of Bodies versus Tails of Schistosoma Mansoni Cercariae: Lectin Binding, Size, Charge and Electron Microscopic Characterization. J. Biol. Chem. 266:1341 1347. Abstract

 

Dennis, J. E., Carrino, D.A., Schwartz, N.B., Caplan, A.I. (1990) "Ultrastructural Characterization of Embryonic Chick Cartilage Proteoglycan Core Protein and the Mapping of a Monoclonal Antibody Epitope." J. Biol. Chem. 265:12098-12103. Abstract

Peng, I., Dennis, J. E., Rodriguez Boulan, E. and Caplan, A.I. (1990) Polarized Release of Enveloped Viruses in the Embryonic Chick Heart: Demonstration of Epithelial Polarity in the Presumptive Myocardium. Dev. Biol. 141:164-172. Abstract

 

Shimizu, T., Dennis, J. E., Masaki, T. and Fischman, D.A. (1985) Axial Arrangement of the Myosin Rod in Vertebrate Thick Filaments: Immunoelectron Microscopy With a Monoclonal Antibody to Light Meromyosin. J. Cell Biol. 101:1115-1123. Abstract

 

Dennis, J. E., Shimizu, T., Reinach, F.C. and Fischman, D.A. (1984) Localization of C Protein Isoforms in Chicken Skeletal Muscles: Ultrastructural Detection Using Monoclonal Antibodies. J. Cell Biol. 98:1514-1522. Abstract

Wallace, E., Calvin, H.I., Salfo, M.P., Dennis, J. E. and Ploetz, K. (1984) Normal Levels of Zinc and Sulfhydryls in Morphologically Abnormal Populations of Spermatozoa From Moderately Zinc Deficient Rats. Gamete Res. 9:375-386. Abstract

 

Jagiello, G.M., Dennis, J. E., Hiura, M. and Ducayen, M. (1983). Incorporation of L 3H Fucose in the Rete and Ovary of the Fetal Mouse. Gamete Res. I7:155-160. Abstract

 

Baum, S.G., Whittner, M., Nadler, J.P., Horowitz, S.B., Dennis, J. E., Schiff, P.B. and Tanowitz, H. (1981) Taxol, A Microtubule Stabilizing Agent, Blocks the Replication of Trypanosoma Cruzi. Proc. Natl Acad. Sci. USA 78:4571-4575. Abstract

 

Hiura, M., Jagiello, G.M., Dennis, J. E. and Ducayen, M. (1980) Ultracytochemical Localization of 3ß hydroxy steroid Ferricyanide Reductase Activity in the Metal Mouse Ovary. Gamete Res. 3:323-328. Abstract