Our research
focuses on elucidating molecular mechanisms of RNA helicases and the function of these enzymes in their cellular environment.
We utilize
techniques ranging from molecular biology and deep sequencing (RNA-seq) to quantitative biochemical and biophysical methods, including single molecule fluorescence.
RNA helicases are the largest class of enzymes in eukaryotic RNA metabolism. RNA helicases use ATP to bind and remodel RNA and RNA-protein complexes. Malfunction or deregulation of RNA helicases has been linked to numerous diseases including cancer, neuro- degenerative disorders and infectious diseases.
contact:
- Center for RNA Molecular Biology
- Wood Bldg. 137, 10900 Euclid Ave.
- Cleveland, OH 44106
- 216.368.3336 office
- 216.368.5741 lab