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Biochemistry Department - Primary Faculty

Zhuli Wan, Ph.D.

Instructor

Education

  • Ph.D.: The Structural Biology, Institute of Biophysics of Chinese Academy of Sciences
  • Postdoc: The Structural Biology Laboratory, The University of York, UK.

Research Interests

My research interests concern structure-function relationships in proteins. The protein structures determined and analysed by X-ray crystallographic methods.

Selected References

  • Wan ZL, Huang K, Hu SQ, Whittaker J & Weiss MA
    “The Structure of a Mutant Insulin Uncouples Receptor Binding from Protein Allostery. an electrosratic block to the TR transition ”
    J. Biol. Chem 283(30),21198-21210 (2008).
  • Wan ZL,Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG & Weiss MA
    “Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama”
    Biochemistry 44(13),5000-5016 (2005).
  • Wan ZL, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG & Weiss MA
    “Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.”
    Biochemistry 43(51),16119-16133 (2004)
  • Bayrer J, Wan ZL, Li B & Weiss MA
    “Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex ”
    Acta Crystallogr D Biol Crystallogr 60,1328-1330.Epub (2004).
  • Wan ZL, Xu B, Chu YC, Katsoyannis PG & Weiss MA
    “Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding ”
    Biochemistry 42(44),12770-83 (2003).

 

Zhuli Wan Faculty's publications at pubmed