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Biochemistry Department - Primary Faculty

Martin Snider, Ph.D.

Professor

Education

  • Ph.D.: Harvard University, 1978
  • Postdoc: Massachusetts Institute of Technology

Research Interests

My work is a collaboration with Dr. Maria Hatzoglou in the Nutrition Department. We are interested in the cellular responses to stresses, including nutrient starvation, viral infection and the accumulation of unfolded proteins. The responses to mild stress lead to the expression of proteins that promote survival, whereas severe stress induces cell death (apoptosis). Our studies focus on the regulatory mechanisms that control both transcription and translation; working together, these mechanisms control the balance between expression of proteins that promote survival or apoptosis.

Selected References

  • Majumder M., Huang C., Snider M. D., Komar A. A., Tanaka J., Kaufman R. J., Krokowski D., and Hatzoglou M.
    “A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation”
    Mol Cell Biol 32 (5): 992-1003 (2012). Read article in PubMedCentral
  • Bevilacqua E., Wang X., Majumder M., Gaccioli F., Yuan C. L., Wang C., Zhu X., Jordan L. E., Scheuner D., Kaufman R. J., Koromilas A. E., Snider M. D., Holcik M., and Hatzoglou M.
    “eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress”
    J Biol Chem 285 (22): 17098-111 (2010). Read article in PubMedCentral
  • Huang C. C., Li Y., Lopez A. B., Chiang C. M., Kaufman R. J., Snider M. D., and Hatzoglou M.
    “Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress”
    Biochem J 429 (1): 215-24 (2010).
  • Huang C. C., Chiribau C. B., Majumder M., Chiang C. M., Wek R. C., Kelm R. J., Jr., Khalili K., Snider M. D., and Hatzoglou M.
    “A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)”
    J Biol Chem 284 (47): 32312-20 (2009). Read article in PubMedCentral
  • Majumder M., Yaman I., Gaccioli F., Zeenko V. V., Wang C., Caprara M. G., Venema R. C., Komar A. A., Snider M. D., and Hatzoglou M.
    “The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation”
    Mol Cell Biol 29 (10): 2899-912 (2009). Read article in PubMedCentral
  • Li Y., Bevilacqua E., Chiribau C. B., Majumder M., Wang C., Croniger C. M., Snider M. D., Johnson P. F., and Hatzoglou M.
    “Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress”
    J Biol Chem 283 (33): 22443-56 (2008). Read article in PubMedCentral
  • Zeenko V. V., Wang C., Majumder M., Komar A. A., Snider M. D., Merrick W. C., Kaufman R. J., and Hatzoglou M.
    “An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation”
    RNA 14 (3): 593-602 (2008). Read article in PubMedCentral
  • Lopez A. B., Wang C., Huang C. C., Yaman I., Li Y., Chakravarty K., Johnson P. F., Chiang C. M., Snider M. D., Wek R. C., and Hatzoglou M.
    “A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation”
    Biochem J 402 (1): 163-73 (2007).
  • Gaccioli F., Huang C. C., Wang C., Bevilacqua E., Franchi-Gazzola R., Gazzola G. C., Bussolati O., Snider M. D., and Hatzoglou M.
    “Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation”
    J Biol Chem 281 (26): 17929-40 (2006).
  • Fernandez J., Yaman I., Huang C., Liu H., Lopez A. B., Komar A. A., Caprara M. G., Merrick W. C., Snider M. D., Kaufman R. J., Lamers W. H., and Hatzoglou M.
    “Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation”
    Mol Cell 17 (3): 405-16 (2005).
  • Fernandez J., Lopez A. B., Wang C., Mishra R., Zhou L., Yaman I., Snider M. D., Hatzoglou M., and Hatzolgou M.
    “Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress”
    J Biol Chem 278 (50): 50000-9 (2003).
  • Yaman I., Fernandez J., Liu H., Caprara M., Komar A. A., Koromilas A. E., Zhou L., Snider M. D., Scheuner D., Kaufman R. J., and Hatzoglou M.
    “The Zipper Model of Translational Control. A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader”
    Cell 113 (4): 519-31 (2003).

 

Martin Snider Faculty's publications at pubmed