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case western reserve university

BIOCHEMISTRY

 
 

PRIMARY FACULTY


Dr. Vernon Anderson,
Enzyme reaction mechanisms, protein-protein interactions, protein oxidation, and mass spectrometry.

Dr. Amiya Banerjee, Gene Expression of Negative-Strand RNA Viruses. Located at CCF.

Dr. Paul Carey, Protein-ligand interaction and Raman spectroscopy.

Dr. Kwaku Dayie, Structural biology of RNA and proteins involved in catalysis and gene regulations, structure-guided drug discovery, and NMR methodology development. Located at CCF.

Dr. Richard Gronostajski, The Nuclear Factor I (NFI) and T-box families of transcription/replication proteins. Located at CCF.

Dr. Richard Hanson, Hormonal control of gene expression.

Dr. Marian Harter, The adenovirus E11A protein: insights into pathways that control cell proliferation and differentiation.

Dr. Qing-Xin Hua, Protein structure and dynamics probed by multidimensional NMR spectroscopy and other biophysical methods.

Dr. Eckhard Jankowsky, Molecular Mechanism of DExH/D RNA helicases.

Dr. Hung-Ying Kao, Signaling pathways controlled by transcription corepressors and histone deacetylases.

Dr. Wesley Kroeze

Dr. Xavier Lee, Protein structure and interaction between proteins and nucleic acid. Located at CCF.

Dr. William Merrick, Mechanism and regulation of eukaryotic protein bioshynthesis.

Dr. Nelson Phillips, Biochemical mechanisms of tissue-specific transcription factors.

Dr. Marianne Pusztai-Carey, Enzymes structure and function.

Dr. Steven Sanders, Histone modifying enzymes and DNA damage response.

Dr. David Samols, Regulation of the acute phase response to inflammation; Function and regulation of the acute phase reactant, C-reactive protein.

Dr. Menachem Shoham, X-ray crystallographic studies of the enzymatic cytotoxin colicin E3 and of G-coupled protein receptors.

Dr. Robert Silverman, Understanding how RNase L mediates effects of interferon against viruses and cancer cells is the long-range goal of the Silverman laboratory. Located at CCF.

Dr. Martin Snider, Intracellular movement of cell-surface receptor during endocytosis.

Dr. Edward Stavnezer, Role of the ski oncogene in cell differentiation and transformation.

Dr. Focco van den Akker, Multi-facetted structural approach to understanding the molecular signal transduction events of membrane receptors.

Dr. Zhu-Li Wan

Dr. Michael Weiss, Structural mechanisms of human diseases, transcriptional deregulation, and protein misfolding with applications to diabetes and disorders of sexual development.

Dr. Yanwu Yang

Dr. Yu-Chung Yang, Cytokine signal transduction, transcription factors, hematopoiesis, and cancer.

Dr. Vivien Yee, Structure-function studies of enzymes and prion proteins using X-ray crystallography.

 

SECONDARY FACULTY


Dr. Nathan Berger
, PolyADP-ribose metabolism in DNA repair and replication.

Dr. Henri Brunengraber, Nutritional Biochemistry.

Dr. James Bruzik, Regulation of alternative pre-mRNA splicing.

Dr. Mark Caprara, Catalytic RNAs, RNPS, and mitochondrial gene expression.

Dr. Jeffery Coller, Translational control and mRNA decay.

Dr. Pieter deHaseth, Mechanism of RNA polymerase-DNA interactions.

Dr. Thomas Gerken, Biosynthesis of O-linked glycans.

Dr. Jonatha Gott, Mechanistic studies of RNA editing in Physarum mitochondria.

Dr. Michael Harris, Mechanisms of catalysis by RNA and protein enzymes.

Dr. Vincent Hascall, Structure, function and metabolism of proteoglycans and hyaluronan in connective tissues.

Dr. Marion Helfand, Structural biology of antimicrobial resistance.

Dr. Douglas Kerr, Metabolic disorders in infants.

Dr. Donal Luse, Eukaryotic gene transcription and RNA polymerase.

Dr. Vincent Monnier, Biochemistry of aging.

Dr. Timothy Nilsen, Mechanisms of post transcriptional gene regulation.

Dr. Nancy Oleinick, Control of cell death and sensitivity of tumor cells to photodynamic therapy.

Dr. Jun Qin, Biomolecular NMR spectroscopy, signal transduction.

Dr. David Sedwick, Genetic approaches to drug mechanism and development

Dr. Ganes Sen, Mammalian gene expression anantiotensin-converting enzyme and interferon.

Dr. John Stuehr, Dynamics of metal complexation reactions and elementary steps in enzymes.

Dr. Saba Valadkhan, Functional analysis of the spliceosome.

Dr. Martina Veigl, Calmodulin regulation in differentiation of blood cells and DNA repair.

Dr. Jonathan Whittaker, Structure and function of the insulin receptor family.

Dr. James Zull, Human learning.