case western reserve university





Kingman P. Strohl, M.D.

Center for Sleep Disorders Research

This center interacts with a wide variety of programs involved in the pathogenesis and management of sleep apnea, a disorder involving the physiology of breathing and sleep. Sleep apnea is a common condition, occurring in some 2 - 4% of the population. There is little recognition of its role in producing illness in the community: however, in its extreme form, those with multiple apneas (upper airway occlusion) during sleep present in middle-age suffering from the complications of sleep interruption (sleepiness) and intermittent asphyxia (hypoxia and hypercapnia). How does this illness develop? What are the mechanisms for symptom expression? Can we create animal models of sleep apnea or its componenets- obesity, blunting of respiratory drive, craniofacial features, upper airway function etc.?

Our concept is breathing and breathing during sleep should be considered as a behavior, in part genetically determined but to a large degree modified by growth and experience. The domains of interest are respiratory and sleep neurobiology. An emerging area of our interest is in the genetic dissection of respiratory traits of ventilatory control and factors that intiate and maintain sleep. Funded projects involve animal models of obesity, ventilatory control, and sleep, as well as human studies of upper airway fucntion and disease expression.

Selected References:

Strohl KP, Thomas AJ, Schlenker EH, Koletsky RJ, St. Jean P, Schork NJ. Ventilation and metabolism among rat strains. J Appl Physiol 82(1):317-323, 1997.

Redline S, Tishler PV, Hans MG, Tosteson TD, Spry K, Strohl KP. Sleep-disordered breathing in african-americans and caucasions: Racial differences in age of onset and underlying risk factors. Am J Respir Crit Care Med 155:186-192, 1997.

Strohl KP, Strobel RJ, Parisi R. Obesity and Pulmonary Function. In: Handbook of Obesity. Eds., Bray GA, Bouchard C, James, WPT, Marcel Dekker, Inc., New York, 725-739, 1997.

Strohl KP, Beall C. Ventilatory responses to experimental hypoxia in adult male and female natives of the Tibetan and Andean plateaus. In: Hypoxia Women at Altitude, Ed. Charles S. Houston, Queen City Printer, Inc., Burlington, Vermont, 154-165, 1997.

Strohl KP, Thomas AS. Neonatal conditioning for adult respiratory behavior. Respiratory Physiology 110:269-275, 1997.

Dick TE, Haxhiu MA, Strohl KP. Respiratory control. In: Comprehensive Textbook of Pulmonary Medicine, Mosby-Year Book, Inc., St. Louis, Missouri, Chapter 4:1-17, 1997.

Strohl KP, Thomas AS. Neonatal conditioning for adult respiratory behavior. Respiratory Physiology 110:269-275, 1997.

Dept. of Anatomy | 10900 Euclid Ave. | Cleveland, Ohio 44106-4930 | Phone:216.368.2433|
2004 Case Western Reserve University | Cleveland, Ohio 44106 | 216.368.2000 | legal notice