The research interest of the lab is to study the
development of the endocrine pancreas. The
endocrine portion of the pancreas, the islets of
Langerhans, contains several cell types. The
most abundant islet cell type is the beta cell,
which secretes insulin. In diabetes, beta cells
are lacking or insufficient. In our research,
morphological, cell biological and molecular
biological techniques are used to study various
aspects of the development of the islets of
Langerhans in rodents and in amphibians. Recent
research emphasis is on the cell lineage
relationships of various islet cell types with
the early endodermal cells of the pancreatic
primordium. The goal of these studies is to
identify progenitor or stem cells that can
regenerate beta cells or to find ways to induce
the regeneration of beta cells.
Kaung, H. C. 1994 Growth
dynamics of pancreatic islet cell populations
during fetal and neonatal development of the
rat. Developmental Dynamics 200:163-175.
Kaung, H. C., Xu, S., Wang,
C., Jacobberger, J. and. W. Chen. 1996 Rat islet
cell lines produced by retroviral transduction
of SV40 T antigen. In Vitro Cell. Dev. Biol. -
Friedman J.E., Ishizuka T.,
Liu S., Farrell C.J., Bedol D., Koletsky R.J.,
Kaung H.C., Ernsberger P 1997 Reduced insulin
receptor signaling in the obese spontaneously
hypertensive Koletsky rat. Am. J. Physiol.
Kaung H.C., Wang C. and
Chen W. 1998 Development of rat islet cell in
vitro-evolution of a beta cell line. Microscopy
Research and Technique 43:306-312.
Early related references:
Kaung, H. C. and R. P. Elde
1980 Distribution and morphometric quantitation
of pancreatic endocrine cell types in the frog,
Rana pipiens. Anat. Rec. 196: 173-181.
Kaung, H. C. 1981.
Immunocytochemical localization of pancreatic
endocrine cells in frog embryos and young
larvae. Gen. and Comp. Endocrinol. 45: 204-211.
Kaung, H. C. 1983 Changes
of pancreatic beta cell population during larval
development of Rana pipiens. Gen. and Comp.
Endocrinol. 49: 50-56.