case western reserve university





Hue-Lee Kaung, Ph.D. 

       The research interest of the lab is to study the development of the endocrine pancreas. The endocrine portion of the pancreas, the islets of Langerhans, contains several cell types. The most abundant islet cell type is the beta cell, which secretes insulin. In diabetes, beta cells are lacking or insufficient. In our research, morphological, cell biological and molecular biological techniques are used to study various aspects of the development of the islets of Langerhans in rodents and in amphibians. Recent research emphasis is on the cell lineage relationships of various islet cell types with the early endodermal cells of the pancreatic primordium. The goal of these studies is to identify progenitor or stem cells that can regenerate beta cells or to find ways to induce the regeneration of beta cells. 

Recent publications: 

Kaung, H. C. 1994 Growth dynamics of pancreatic islet cell populations during fetal and neonatal development of the rat. Developmental Dynamics 200:163-175.

Kaung, H. C., Xu, S., Wang, C., Jacobberger, J. and. W. Chen. 1996 Rat islet cell lines produced by retroviral transduction of SV40 T antigen. In Vitro Cell. Dev. Biol. - Animal 32:197-203.

Friedman J.E., Ishizuka T., Liu S., Farrell C.J., Bedol D., Koletsky R.J., Kaung H.C., Ernsberger P 1997 Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat. Am. J. Physiol. 273:E1014-E1023.

Kaung H.C., Wang C. and Chen W. 1998 Development of rat islet cell in vitro-evolution of a beta cell line. Microscopy Research and Technique 43:306-312.

Early related references:

Kaung, H. C. and R. P. Elde 1980 Distribution and morphometric quantitation of pancreatic endocrine cell types in the frog, Rana pipiens. Anat. Rec. 196: 173-181.

Kaung, H. C. 1981. Immunocytochemical localization of pancreatic endocrine cells in frog embryos and young larvae. Gen. and Comp. Endocrinol. 45: 204-211.

Kaung, H. C. 1983 Changes of pancreatic beta cell population during larval development of Rana pipiens. Gen. and Comp. Endocrinol. 49: 50-56.

Dept. of Anatomy | 10900 Euclid Ave. | Cleveland, Ohio 44106-4930 | Phone:216.368.2433|
2004 Case Western Reserve University | Cleveland, Ohio 44106 | 216.368.2000 | legal notice