Metabolism Training Program
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The research

Affiliated Hospitals.



Collaborative Research.

There are numerous collaborative interactions between Program trainers: 
Dr. Brunengraber collaborates with (i) Drs. Tochtrop and Salomon on the metabolism of 4-hydroxyacids, (ii) Dr. Stamler on the metabolism of S-nitroso-CoA in yeast, (iii) Dr. Xin Yu on modeling isotopic labeling of metabolites in tissues, (iv) Dr. Erzurum and Dr. Kalhan on the metabolism of citrulline in lung epithelium cells from patients with severe, corticosteroid-insensitive asthma, and (v) Dr. Irina Pikuleva (ophthalmology) on the metabolism of pyridoxine in mouse retina. 

Dr. Tochtrop collaborates with (i) Dr. Noy on the differential metabolism of furan-fatty acids in normal and cancerous tissues, and (ii) with Dr. Gupta on the impact of triterpenoid modulators of inflammatory-driven carcinogenesis molecules in the prostate.

Drs. Salomon and Pikuleva collaborate on the metabolism of isolevuglandins in retina.

Drs. Weiss and Ismail-Beigi work on the metabolic effects of insulin analogs that target liver cells.

Drs. Salomon and Nagy work on the formation of ketoaldehyde-protein adducts in ethanol-induced liver injury.

Drs. Palczewski and von Lintig collaborate on aspects of vitamin A metabolism in the eye.

Drs. Jain and Stamler collaborate on Kruppel-like factor metabolic effects.

Drs. Kern and Ismail-Beigi collaborate on GLUT-1 expression in the retina, and on the potential of 6-fluoro-6-deoxy-D-glucose as a new tracer of glucose transport.

Drs. Hanson and Kalhan have a long collaboration on gluconeogenesis in genetically-engineered mice.

Drs. Hazen collaborates (i) with Dr. Kirwan on metabolomics of patients who have undergone bariatric surgery or are suffering from steatohepatitis, (ii) with Dr. Erzurum on metabolomics of patients with pulmonary arterial hypertension or asthma, and (iii) with Dr. Fox on the protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease.

Drs. Tochtrop and Salomon collaborate on the design and synthesis of a number of stable isotopic tracers for members of the Program and for users of the Case Mouse Metabolic Phenotyping Center (MMPC).

The Training Environment.

PRE-DOCTORAL TRAINING: Academic Curriculum for Graduate Students in the Program ? The Metabolism Training Program is part of the interdepartmental Biomedical Scientist Training Program (BSTP) at CWRU (see web site All graduate students are formally enrolled in the BSTP and can receive a PhD degree from a variety of participating graduate education programs. Therefore, our trainees are not restricted to only one or two departments of the Medical School.

Graduate students are invited to begin their education early in the summer before the school year officially begins in order to become acquainted with the research activities of our faculty.  Many of the new students work on research projects in the laboratories of the Training Faculty and have an early exposure to the metabolic research available to them during their thesis years.

Curriculum in Metabolism and Nutrition at CWRU leading to a PhD Degree:
A PhD program, linking nutrition and metabolic biochemistry with molecular biology and genetics, is offered to all trainees in the Metabolism Training Program.  This educational component of the Program builds on core courses in the Departments of Nutrition, Biochemistry, Genetics, Molecular Biology, Pharmacology, Physiology, and Biomedical Engineering.


POST-DOCTORAL TRAINING:  Postdoctoral scholars are admitted into the Program uncommitted to an individual investigator and are provided support for the full 3 years of training. The Program welcomes both PhD and MD scholars for training and has been successful over the years in attracting and supporting MD scholars for a career in academic medicine in areas related to metabolic research. The career progress of postdoctoral scholars supported by the Program is reviewed regularly by the Steering Committee to insure that the trainees are achieving their research goals. Postdoctoral scholars planning a traditional academic career in a university setting are provided an opportunity to teach a metabolic elective in an advanced seminar course taught to undergraduates in the Dept of Biochemistry.

Metabolic Regulation Journal Club:  The Program organizes and sponsors a Metabolic Regulation Journal Club devoted to topics in metabolic research. The Journal Club is attended by a broad cross section of faculty and students both in an out of the Program. The Journal Club was organized in 1978 by the Program leadership as a vehicle for maintaining an interest in metabolism and has been expanded in its emphasis to include areas of molecular and cellular biology and biochemistry as they relate to the interests of the participants. The Journal Club may often present material outside the normal field of interest of a trainee, and thus serve as a means of broadening the education of our students, scholars and faculty. In making Journal Club presentations, the trainees practice the preparation and delivery of a scientific lecture.


Departmental Seminars, a Metabolism Interest Discussion Group, Metabolism-specific Seminar Program, and Memorial Lectures are organized and offered every semesters.



The CWRU School of Medicine is very well funded by the NIH.  This level of support and the generous investment of the University and members of the Cleveland community, has allowed us to build an excellent, modern research environment to support the work of our Training Faculty. This environment is available to the trainees of the Program.

During the past 10 years, there have been several important developments in the research environment at CWRU that impacted significantly on the Metabolism Training Program. These include the establishment of Biomedical Research Cleveland, an organization consisting of Case Western Reserve University, The Cleveland Clinic Research Foundation, Cleveland State University, MetroHealth Center and University Hospitals of Cleveland.

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Have a question? From deadlines to requirements, please email Dr. Henri Brunengraber  (Program Director) at:

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