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AFFILIATED
HOSPITALS
UNIVERSITY OF CLEVELAND - UHC
METROHEALTH MEDICAL CENTER
CLEVELAND CLINIC FOUNDATION - CCF/Dept. of Molecular Medicine
COLLABORATIVE
RESEARCH
| Drs
Hanson and
Kalhan: Perinatal Research Center of CWRU
- studying the regulation of metabolic processes in the
fetus and the mother during the immediate perinatal period. |
| Drs
Hoppel, Stanley and
Brunengraber collaborate in studies on
the potential of anaplerotic medium-odd-chain fatty acids
for the treatment of cardiac reperfusion injury. |
| Drs Weiss and
Whittaker collaborate on studies of the
molecular mechanisms underlying interactions of the insulin-IGF
family of peptides and their cognate receptors. |
| Drs Hatzoglou
and Snider work on the regulation of
expression of the cat1 gene which encodes a plasma membrane
transporter for the cationic amino acids, arginine and
lysine. |
| One of our former trainees, Dr
Colleen Croniger PhD, Assistant Professor in
the Dept of Nutrition of CWRU, collaborates with Dr
Satish Kalhan, studying the development of carbohydrate
metabolism. |
| The above mentioned collaborations
are just some of the several active participations between
MTP trainers and past trainees. |
TRAINING
ENVIRONMENT
Pre-Doctoral Training:
Academic Curriculum for Graduate Students in the Program ? The
Metabolism Training Program is part of the interdepartmental
Biomedical Scientist Training Program (BSTP) at CWRU (see web
site http://www.cwru.edu/med/BSTP/index.html).
All graduate students are formally enrolled in the BSTP and
can receive a PhD degree from a variety of participating graduate
education programs. Therefore, our trainees are not restricted
to only one or two departments of the Medical School.
Graduate students are invited to begin their education
early in the summer before the school year officially begins
in order to become acquainted with the research activities of
our faculty. Many of the new students work on research projects
in the laboratories of the Training Faculty and have an early
exposure to the metabolic research available to them during
their thesis years.
Curriculum in Metabolism and Nutrition at CWRU leading
to a PhD Degree
A PhD program, linking nutrition and metabolic biochemistry
with molecular biology and genetics, is offered to all trainees
in the Metabolism Training Program. This educational component
of the Program builds on core courses in the Departments of
Nutrition, Biochemistry, Genetics, Molecular Biology, Pharmacology,
Physiology, and Biomedical Engineering.
Post-Doctoral Training:
Postdoctoral scholars are admitted into the Program uncommitted
to an individual investigator and are provided support for the
full 3 years of training. The Program welcomes both PhD and
MD scholars for training and has been successful over the years
in attracting and supporting MD scholars for a career in academic
medicine in areas related to metabolic research. The career
progress of postdoctoral scholars supported by the Program is
reviewed regularly by the Steering Committee to insure that
the trainees are achieving their research goals. Postdoctoral
scholars planning a traditional academic career in a university
setting are provided an opportunity to teach a metabolic elective
in an advanced seminar course taught to undergraduates in the
Dept of Biochemistry.
Metabolic Regulation Journal Club - The
Program organizes and sponsors a Metabolic Regulation Journal
Club devoted to topics in metabolic research. The Journal Club
is attended by a broad cross section of faculty and students
both in an out of the Program. The Journal Club was organized
in 1978 by the Program leadership as a vehicle for maintaining
an interest in metabolism and has been expanded in its emphasis
to include areas of molecular and cellular biology and biochemistry
as they relate to the interests of the participants. The
Journal Club may often present material outside the normal field
of interest of a trainee, and thus serve as a means of broadening
the education of our students, scholars and faculty. In making
Journal Club presentations, the trainees practice the preparation
and delivery of a scientific lecture.
Also available:
Departmental Seminars;
Metabolism Training Discussion Group; Seminar Program in Metabolism;
Memorial Lectures.
RESEARCH
ENVIRONMENT
The CWRU School of Medicine is currently ranked
15th in NIH funding. This level of support and the generous
investment of the University and members of the Cleveland community,
has allowed us to build an excellent, modern research environment
to support the work of our Training Faculty. This environment
is available to the trainees of the Program. During the past
10 years, there have been several important developments in
the research environment at CWRU that impacted significantly
on the Metabolism Training Program. These include the establishment
of Biomedical Research Cleveland, an organization consisting
of Case Western Reserve University, The Cleveland Clinic Research
Foundation, Cleveland State University, MetroHealth Center and
University Hospital of Cleveland.
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