Metabolism Training Program
MTP › faculty

The training faculty.

Program Director

Henri Brunengraber, M.D., Ph.D.

Mt Sinai Auxiliary Professor  Department of Nutrition  |  CASE School of Medicine
Director   |  CASE Mouse Metabolic Phenotyping Center

RESEARCH  Regulations of the pathways of intermediary metabolism investigated by metabolomics coupled with stable isotope technologies.


Program Steering Committee

Rose Gubitosi-Klug, M.D., Ph.D.

Mary Blossom Lee Chair in Pediatric Diabetes  Pediatric Endocrinology  |  UH Case Medical Center
Assistant Professor   Pediatric Endocrinology  |  UH Case Medical Center
PI   EDIC Clinical Coordinating Center

RESEARCH  Pediatric Endocrinology - Diabetes - Metabolism.

Irina Pikuleva, Ph.D.

Jules and Doris Stein Professor  Departments of Ophthalmology (primary) and Pharmacology (secondary)  CASE School of Medicine

RESEARCH  Pharmacologic stimulation of cholesterol turnover in the brain and the link between cholesterol and diseases of the retina.

 

Other Training Faculty

Walter F. Boron, M.D., Ph.D.

David N. and Inez Myers/Antonio Scarpa Professor   Department of Physiology & Biophysics   CASE - School of Medicine

RESEARCH  Mechanism of ion and molecules transfer across various sections of the mammalian nephron, using molecular biology and cell biology techniques. Emphasis is on the bicarbonate transporter and its regulation.

George Dubyak, Ph.D.

Professor   Department of Physiology & Biophysics | CASE School of Medicine

RESEARCH  Fundamental aspects of nucleotide-based signal transduction: (i) the physiological and pathological roles of extracellular ATP in various pro-inflammatory cascades, and (ii) the mechanisms by which ATP and other nucleotides are released into, and metabolized within extracellular compartments.

Serpil C. Erzurum, M.D.

Chair   Department of Pathobiology    Cleveland Clinic | Lerner Research Institute
Joint Staff  The Respiratory Institute

RESEARCH  Asthma, Exhaled markers in lung disease, lung biology and physiology, pulmonary hypertension, Nitric oxide (NO) in lung physiology and disease.


Paul L. Fox, Ph.D.

Robert Canova Professor  Department of Cellular & Molecular Medicine
Cleveland Clinic  Lerner Research Institute

RESEARCH Metabolic pharmacology defined as the study of the mechanisms of action of therapeutic agents with potential in metabolic diseases such as insulin resistance syndrome.


Sanjay Gupta, Ph.D., M.S.

Carter Kissell Associate Professor and Research Director  
Department of Urology | CASE School of Medicine

RESEARCH Metabolism of prostate cancer.


Maria Hatzoglou, Ph.D.

Professor  Department of Pharmacology  |  CASE  School of Medicine

RESEARCH  Nutrient control of gene expression and the characterization of adaptive responses of cells to limited supply of nutrients.


Stanley L. Hazen M.D., Ph.D.

The Jan Bleeksma Chair  Vascular Cell Biology and Atherosclerosis
The Leonard Krieger Chair  Preventive Cardiology
Chair  Department of Cellular & Molecular Medicine | Cleveland Clinic Lerner Research Institute
Director  Center for Cardiovascular Diagnostics & Prevention Section Head, Preventive Cardiology & Rehabilitation

RESEARCH  Inflammation; Atherosclerosis; Asthma; Metabolomics; Myeloperoxidase; Cardiovascular diseases; HDL; Peroxidases; Airway remodeling; Intestinal microbiota; Gut flora; Cardiometabolic diseases.


Faramarz Ismail-Beigi, M.D., Ph.D. (Resource person for Clinical Research)

Professor of Medicine  Clinical and Molecular Endocrinology  |  CASE  School of Medicine

RESEARCH  Bioenergetics and the control of ATP production and utilization; Diabetes; Thyroid Disease.


Mukesh Jain, FAHA, M.D.

Ellery Sedgwick Jr. Chair and Distinguished Scientist  UH Case Medical Center
Professor and Director  Cardiovascular Research Institute  |  UH Case Medical Center

RESEARCH  Transcriptional mechanisms governing cellular differentiation and function, highlighting the importance of a family of factors termed Kruppel-like factors that regulate critical aspects of heart, blood vessel, and immune cell biology.


Satish C. Kalhan, M.D. (Resource person for Clinical Research)

Professor   Department of Pathobiology - Cleveland Clinic  |  Lerner Research Institute

RESEARCH  Metabolic adaptive responses of the mother during normal pregnancy and the role of maternal insulin resistance on maternal protein metabolism and fetal growth, the significance and mechanism of insulin resistance in puberty, and the consequence of insulin resistance on muscle protein metabolism in liver disease.


Timothy S. Kern, Ph.D.

Professor   Departments of Medicine (Clinical and Molecular Endocrinology) and Pharmacology
CASE  School of Medicine

RESEARCH  Causes and mechanisms of diabetic retinopathy (a leading cause of acquired blindness among young adults in the US) and how it can be prevented.


John P. Kirwan, Ph.D.

Associate Professor  Department of Gastroenterology & Hepatology  |  Cleveland Clinic  Lerner Research Institute
Secondary Appointment  Department of Pharmacology  |  CASE  School of Medicine

RESEARCH  (1) How exercise and diet alter the disease risks associated with insulin resistance, obesity, type 2 Diabetes and cardiovascular disease in the elderly; (2) How aerobic exercise training and dietary restriction interventions improve cardio-respiratory function and reverse insulin resistance in the elderly.

Michael E. Maguire, Ph.D.

Professor  Departments of Pharmacology and Molecular Biology and Microbiology
CASE School of Medicine

RESEARCH  The multiple roles of Mg2+ Transport and Mn2+ in bacterial metabolism and pathogenesis using primarily Salmonella Typhimurium as a model system.


Danny Manor, Ph.D.

Associate Professor  Department of Nutrition  |  CASE School of Medicine

RESEARCH  Molecular-level treatment and prevention of cancer.


Christine McDonald, M.D., Ph.D.

Assistant Professor  (Molecular Medicine)  Department of Pathobiology  |  Cleveland Clinic Lerner Research Institute

RESEARCH  Molecular mechanisms involved in inflammatory bowel disease pathogenesis with a particular focus on anti-microbial responses mediated by the bacterial sensor NOD2.


John Mieyal, Ph.D.

Professor  Department of Pharmacology  |  CASE School of Medicine

RESEARCH  Enzymatic reaction mechanisms involved in intracellular sulfhydryl homeostasis and redox signal transduction in health and diseases, including cancer, cardiovascular and neurological disorders, and diabetes.


Vincent M. Monnier, M.D.

Professor  Department of Pathology  |  CASE School of Medicine

RESEARCH  Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology: the chemistry and biology of amino-carbonyl reactions in the aging human lens. The Maillard reaction is initiated by the nonenzymatic condensation of highly reactive carbonyl compounds derived from reducing sugars, such as glucose, ascorbic acid, or the oxoaldehydes glyoxal and methylglyoxal.


Laura Nagy, Ph.D.

Professor  Department of Pathobiology  |  Cleveland Clinic Lerner Research Center
Secondary Appointment  Department of Nutrition  |  CASE School of Medicine

RESEARCH  The molecular mechanisms of alcoholic liver disease, focusing particularly on the effects of ethanol on receptor-dependent signal transduction.


Perrie O'Tierney-Ginn, Ph.D.

Staff Scientist  Center for Reproductive Health R358 - Department of OB/GYN, MetroHealth Medical Center | Cleveland, OH

RESEARCH  Metabolism of fatty acids in the placenta.


Krzysztof Palczewski, Ph.D.

John H. Hord Professor and Chair  Department of Pharmacology
CASE School of Medicine

RESEARCH  To understand the retinoid metabolism. Specifically, our focus is on (1) the retention of retinoids and (2) isomerization of all-trans-retinyl esters to 11-cis-retinol, a fundamental process of the chromophore formation essential for our vision around.


Robert G. Salomon, Ph.D.

Charles Fredrick Mabery Professor of Research in Chemistry    Department of Chemistry
CASE  College of Arts and Sciences

RESEARCH  Biochemistry, Chemical Biology, Medicinal Chemistry, Organic Chemistry, Bio-Organic Chemistry, Cellular Biology, Molecular Biology, Natural Products, Pharmacology, Synthesis.

Gregory P. Tochtrop, Ph.D.

Associate Professor    Department of Chemistry  |  CASE  College of Arts and Sciences

RESEARCH  Chemical Biology; Metabolomics coupled with stable isotope technology; Medicinal Chemistry; Bioorganic Chemistry.

Johannes von Lintig, Ph.D.

Associate Professor    Department of Pharmacology  |  CASE School of Medicine

RESEARCH  Metabolism of retinoids in relation to metabolic control, cell proliferation and, vision.

Michael A. Weiss, M.D., Ph.D., M.B.A.

Chair  Department of Biochemistry  |  CASE School of Medicine
Cowan-Blum Professor of Cancer Research
Professor of Biochemistry and Medicine  Division of Endocrinology  |  CASE School of Medicine

RESEARCH  Control of gene expression and protein folding and misfolding. Links are made to clinical phenotypes or disease mechanisms. Studies of gene expression include analysis of mammalian and viral transcription factors.


Tony Wynshaw-Boris, M.D., Ph.D.

Charles J. Epstein Professor  of Human Genetics and Pediatrics
Chief, Division of Medical Genetics
Department of Pediatrics and Institute of Human Genetics  |  UCSF School of Medicine

RESEARCH  Metabolic effects of inborn disorders of metabolism


Xin Yu, Sc.D.

Associate Professor  Department of Biomedical Engineering  |  CASE School of Medicine

RESEARCH  Cardiovascular physiology; magnetic resonance imaging and spectroscopy; characterization of the structure-function and energy–function relationships in normal and diseased hearts; small animal imaging and spectroscopy.

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Have a question? From deadlines to requirements, please email Dr. Henri Brunengraber  (Program Director) at: hxb8@case.edu