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Departments of Medicine and Pathology, Divisions of Rheumatic and Infectious Diseases
Biomedical Research Building 1028
Dr. Anthony graduated in Biochemistry from Case Western Reserve University in 1986. He completed his Ph.D. in Biochemistry at CWRU in 1991, followed by his M.D. in 1993. He went on to complete his Residency in Internal Medicine at University Hospitals Cleveland and is presently an Associate Professor in the Departments of Medicine and Pathology of CWRU and Staff Physician at the Louis Stokes Cleveland DVA Medical Center.
Hepatitis C virus (HCV) is the most common cause of chronic viral hepatitis in the United States, and roughly 30% of HIV infected individuals are coinfected with HCV. Defects in dendritic cells (DC), T cells, and NK cells are present in both HCV and HIV infection.
In the setting of HCV and HCV-HIV infection our work is focused on:
1. Determine the contribution of DC-NK cell interactions to control of HCV infection.
2. Identify the quality of DC-T cell interactions in the setting of HCV and HIV infeciton.
3. Determining anatomic compartmentalization of host cellular immunity.
4. Identifying DC, T cell, and B cell immune markers predictive of host response to neoantigenic challenge.
5. Define B cell phenotypic and functional factors that contribute to HCV associated autoimmune disease.
Anthony DD, Umbleja T, Aberg JA, Kang M, Medvik K, Lederman MM, Peters MG, Koziel MJ, Overton ET. Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine. 2011 Apr 27;29(19):3558-63.
Yonkers NL, Sieg S, Rodriguez B, Anthony DD. Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection. J Infect Dis. 2011 Mar 1;203(5):635-45.
Canaday DH, Burant CJ, Jones L, Aung H, Woc-Colburn L, Anthony DD. Preserved MHC-II antigen processing and presentation function in chronic HCV infection. Cell Immunol. 2011;266(2):187-91.
Sugalski JM, Rodriguez B, Moir S, Anthony DD. Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. J Immunol. 2010 Sep 1;185(5):3019-27.