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This page describes the research interests of over 200 researchers who are members of the BSTP training programs. The wide range of research areas represented here highlights the strength of the BSTP, which allows students to choose a thesis topic in almost any area of the biomedical sciences.
PhD trainers provide intellectual and financial support to students during their education and represent the most important mentors for the scientific development of young researchers. Trainers are periodically reviewed. Please contact Dr. Alison Hall for more information.
Many of the faculty members listed below have web pages that describe their research in more depth. Clicking on a name will open their page in a new window.
Abbott, Derek | Innate Immune and Inflammatory Signaling |
Alagramam, Kumar | Genetic basis of hearing loss: Analysis of genes involved in sensory hair cell development and susceptibility to noise-induced hearing loss using a mouse model system |
Aldred, Micheala | Clinical problems arising from 2q37 deletion syndrome. |
Almasan, Alexandru | Mechanisms of cell cycle control and cell death in tumor cells. |
Anderson, James | Biocompatability, immune responses to foreign materials, phagocytosis, inflammation |
Andrulis, Erik | RNA surveillance mechanisms; exosome structure and function; regulation of transcription elongation; heat shock gene expression |
Anthony, Donald | Immunopathogenesis of hepatitis C virus and HIV-hepatitis C virus infection |
Arts, Eric | HIV-1 drug resistance to nucleoside and chemokine analogs; HIV-1 evolution and emergence of drug resistance in Africa. |
Baker, Kristian | Regulation of gene expression at the level of RNA transport, translation and turnover. mRNA quality control. Mechanisms underlying recognition and degradation of nonsense codon-containing mRNA |
Bedogni, Barbara | Interaction between oncogenes and the tissue microenvironment in the development and progression of melanoma |
Bergmann, Cornelia | Interaction between the central nervous system and immune responses to microbial infection |
Bernstein, Helene | HIV immunopathogenesis; CD4 expression on NK cells; Tumor immunology; Maternal and Neonatal Immune Function; Flow cytometry |
Bonomo, Robert | Structure function studies of Class A beta-lactamases. Understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic. Development of immunological tools to study beta-lactamase expression in enteric bacilli. |
Boom, Henry | CD4+ T cells, CD8+ T cells, gamma delta T cells, tuberculosis, cytokines, antigen processing, anti-microbial immunity, HIV-1, pulmonary host defense |
Boron, Walter | Acid-base homeostasis, Gas channels |
Brady-Kalnay, Susann | Receptor protein tyrosine phosphatases, cell adhesion, and signal transduction; PTPs in adherens junctions and desmosomes. |
Broihier, Heather | Genetic and molecular analyses of motorneuron specification and differentiation |
Brunengraber, Henri | Metabolic regulation, ketone body metabolism, design and testing of synthetic nutrients, ethanol metabolism, lipogenesis |
Buck, Matthias | Structure/dynamics of protein complexes involved in cancer and in cardiovascular development: Molecular mechanism of plexin, Eph transmembrane receptors and small GTPases in cell motility |
Canaday, David | Mechanisms of increased pathogenesis during HIV/TB co-infection specifically involving properties of macrophages and dendritic cells. Predictors of influenza and shingles vaccination failure in older adults. |
Carey, Paul | Enzyme mechanisms, Raman spectroscopy, proteases, physical biochemistry |
Carlin, Cathleen | Receptor tyrosine kinase signaling, human adenoviruses, protein sorting |
Casadesus, Gemma | Neuroendocrinology, metabolism, cellular and molecular aspects of learning and memory, rodent behavior, aging, and Alzheimer’s Disease |
Chakrapani, Sudha | Structural dynamics underlying ligand- and voltage-gated ion channel function. EPR spectroscopy, electrophysiology and X-ray crystallography. |
Chance, Mark | High-throughout structure and systems biology |
Chen, Shu | Aging; cell biology; dementia; degenerative disease; neuroscience; prion disease; protein chemistry |
Chiel, Hillel | Neural networks, electrophysiology, modeling, Aplysia, biomechanics, feeding behavior. |
Chisolm, Guy | Cellular effects of bioactive products of lipoprotein oxidation in inflammation and atherosclerosis. Intracellular signaling events of apoptosis in vascular cells induced by bioactive lipids. Genetically altered mouse models of vascular disease. |
Cobb, Brian | Adaptive immune responses to carbohydrate-encapsulated bacterial pathogens, utilizing confocal microscopy, analytical biochemistry, animal models, fluorescence spectroscopy, and traditional cellular immunology. |
Coller, Jeffery | Regulation of the translation rate of cellular mRNAs. Movement of mRNAs from ribosomes to P-bodies as a mechanism of translational control. |
Cominelli, Fabio | Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis |
Conlon, Ron | Targeted Mutagenesis in Mice, Gene controlling morphogenesis and pattern formation in mice, New Approaches to Genome Mapping in the Mouse |
Cooper, Kevin | Psoriasis; atopic dermatitis; autoimmunity; cutaneous immunobiology; UV and solar effects; immunomodulatory therapy |
Croniger, Colleen | Metabolism, CAAT/enhancer binding protein beta (C/EBP beta), transcription, Phosphoenolpyruvate carboxykinase (PEPCK), knockout animal models, perinatal metabolism. |
Danielpour, David | Function and regulation of TGF-ß in the prostate |
Dealwis, Chris | To study the structure-function relationship of macromolecules using structural biology and biochemical tools. |
deBoer, Piet | Bacterial molecular genetics; biochemistry and cell biology; formation of the division of septum and related cell cycle events |
deHaseth, Pieter | Mechanism of RNA polymerase-DNA interactions; Mechanism and control of initiation of RNA synthesis |
Deneris, Evan | Mechanisms of neuronal gene expression, cholinergic and serotonergic transmitter systems. |
Devireddy, Lax | Apoptosis, cancer cell metabolism, and intracellular trafficking |
DiCorleto, Paul | Endothelial Cell Expression of Leukocyte Adhesion Molecules. Homeobox Gene Expression by the Endothelium. Regulation of PDGF Production by the Endothelium. |
Distelhorst, Clark | Steroid hormone action; programmed cell death; apoptosis. |
Driscoll, Donna | RNA editing, translational recoding events, posttranscriptioanl gene regulation |
Drumm, Mitch | Cystic Fibrosis; Site-Directed Mutagenesis; Structure-Function of Ion Channels |
Dubyak, George | Signal transduction involving receptors for extracellular ATP; inflammatory signal transduction mechanisms; mechanisms of nucleotide release and extracellular metabolism. |
Durand, Dominique | Computational Neuroscience, electrophysiology, hippocampus. |
Egelhoff, Thomas | Regulation of cytoskeletal force generation; nonmuscle myosin and actin dynamics, cell migration and cytokinesis; cancer cell migration; skin wound healing |
Eng, Charis | Clinical cancer genetics |
Engel, Andreas | Structure and function of membrane proteins of different origin |
Fairchild, Robert | Skin disease, Skin and cardiac allograft rejection, T cell recruitment to inflammation in peripheral tissues |
Fernandez Galan, Roberto | Biophysical mechanisms underlying neuronal synchronization and the formation of spatiotemporal patterns of neural activity. |
Finke, James | Tumor immunity, T lymphocytes, signal transduction, oxidative stress and T-cell dysfunction in cancer |
Ford, Christopher | Electrophysiology, electrochemistry, and imaging studies of the mechanisms regulating dopamine synaptic transmission in the midbrain. Disruption of dopamine signaling in neuropsychiatric diseases like drug addiction and schizophrenia |
Fox, Paul | Regulation of Endothelial Cell Motility, Role of Ceruloplasmin in Inflammation and Atherosclerosis, Iron Homeostasis |
Friel, David | Calcium homeostasis, electrophysiology, ion channels, modulation, optical methods for measuring Ca2+, modeling. |
Gambetti, Pierluigi | Prion disease, neurodegenerative disorders, prion protein, protein conformation, transgenic animals, transfected cells, animal models, cell models, prion protein gene, spongiosis, anatomical-clinical correlation, polymorphism, genotype phenotype correla |
Gao, Yong | HIV diversity, anti-HIV vaccine development and discovery of novel broadly anti-HIV neutralizing antibodies |
Gerken, Thomas | Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins |
Gerson, Stanton | Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells |
Gott, Jonatha | RNA editing mechanisms, control of gene expression, Physarum genetics |
Greenfield, Edward | Osteoporosis, loosening of orthopaedic implants, cytokines, osteoblasts, osteoclasts, bone resorption, cell-cell interactions |
Gupta, Sanjay | Biomarker(s) for early detection and prognosis of prostate cancer; molecular targets for prevention and treatment of prostate cancer; chemoprevention of prostate cancer by dietary agents; epigenetic mechanisms of gene silencing and its reactivation by natural agents |
Hamilton, Thomas | Analysis of mechanisms regulating inflammatory gene expression in mononuclear phagocytes. Analysis of stimulus-dependent control of chemokine and cytokine mRNA stability |
Han, Yiping | Mechanism of bacterial pathogenesis in periodontal disease and preterm birth. Host-pathogen interactions. Bacterial adhesin structure-function analysis. Vaccine development |
Harding, Clifford | Immunology, MHC, antigen processing, T cell, phagocytosis, endocytosis, subcellular fractionation, mycobacteria, tumor immunity |
Harris, Michael | Mechanistic enzymology of phosphoryl transfer enzymes, multiple substrate recognition by enzymes, RNA-metal ion interactions and RNA folding. |
Harte, Peter | Transcription Activation; Repression; Chromatin Structure; Homeotic Genes |
Harter, Nikki | The adenovirus E 1 A protein: providing insight into pathways that control cell proliferation and differentiation |
Hatzoglou, Maria | Molecular mechanisms of the cellular response to stresses, including inflammation and diabetes. Tissue culture and mouse models of stress-induced transcriptional and translational mechanisms under disease conditions |
Hazen, Stanley | Biochemical mechanisms of oxidant stress and inflammation in cardiovascular disease and asthma |
Hise, Amy | Innate immune responses to microbial pathogens and parasites. |
Hodges, Craig | Animal models of cystic fibrosis; growth and reproduction |
Hoppel, Charles | Role of carnitine in the control of fatty acid oxidation; carnitine biosynthesis and metabolism at the cellular and clinical levels. |
Huang, Alex | Regulation between immune activation and tolerance is crucial in the pathogenesis of cancer. |
Imanishi, Yoshikazu | Localization of proteins and chemical intermediates invloved in phototransduction and the visual cycle. |
Iyengar, Sudha | Molecular and statistical genetic dissection of multifactorial diseases; common chronic diseases of the eye and the kidney; speech sound disorder |
Jackson, Mark | Genetic events that contribute to breast hyperplasia |
Jacobberger, James | Oncogene expression/cell proliferation, cell cycle regulation, immortalization of cells, analytical cytology, SV40 T-antigen |
Jankowsky, Eckhard | Single molecule enzymology (RNA helicases) & single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing) |
Jones, Stephen | Voltage dependent ion channels, electrophysiology, patch clamp, Ca2+ currents, K+ currents. |
Kao, Hung-Ying | Regulation of Gene Expression. Signaling pathways controlled by transcription co-repressors and histone deacetylases |
Karn, Jonathan | HIV, AIDS, transcription, chromatin, retroviral vectors |
Katz, David | Regulatory interactions in development of the nervous system, neurotransmitter phenotypes, neural growth factors. |
Kazura, James | Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria |
Kelley, Thomas | Inflammatory processes in cystic fibrosis lung disease, inflammatory cell signaling mechanisms |
Keri, Ruth | Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer. |
Kern, Timothy | Pathogenesis and prevention of retinopathy and other complications of diabetes; vascular cell apoptosis. |
Khalil, Ahmad | Functional genomics of large non-coding RNAs, RNA-mediated epigenetic regulation |
King, Christopher | T cell differentiation, malaria, schistosomiasis, filariasis, neonatal immunity, IgE regulation, mechanisms of acquired immunity |
Kirwan, John | Nutrient metabolism, insulin action, body composition, and physical activity. Effects of age, exercise, and diet on glucose-lipid metabolism and growth regulation in pregnancy. |
Kong, Qingzhong | Molecular pathology of neurodegenerative diseases, inducible/conditional transgenic/knockout animal model systems |
Kunze, Diana | Ion channels, neural electrophysiology. |
Ladd, Andrea | Pre-mRNA alternative splicing regulation in vertebrate heart and muscle development |
LaFramboise, Thomas | Developing and applying computational tools to identify molecular variants that contribute to cancer and related diseases in humans. |
Lamb, Bruce | Alzheimer's Disease, Transgenic Mouse Models, Mouse Models of Human Disease |
Landreth, Gary | Nerve growth factor, protein kinases, MAP 2 kinase, Alzheimer's disease. |
Lederman, Michael | Immune mechanisms and immune restoration in HIV infection |
Lee, Irene | |
Lefebvre, Veronique | Transcriptional control of cell fate and differentiation |
Letterio, John | TGF-ß in immune cell development and function |
Levine, Alan | Intestinal Host Defense: Immune tolerance, immune protection, and colon cancer |
Li, Xiaoxia | Signal transduction in innate and adaptive immunity |
Licatalosi, Donny | Gene expression, alternative RNA regulation, protein-RNA interactions, mammalian germ cell biology |
Lodowski, David | X-ray and electron microscopic structural studies of the macromolecular complexes that underlie the activation of G protein-coupled receptors and G proteins |
Lou, Hua | Alternative RNA processing and its role in cancer development |
Luo, Guangbin | Mouse models for RecQ DNA helicase diseases and transposon-tagged mutagenesis in mice |
Luse, Donal | Eukaryotic gene transcription and RNA polymerase |
MacDonald, Paul | Vitamin D and vitamin D receptor-mediated gene expression, nuclear receptor coactivators, nuclear receptors and mechanisms of transcriptional regulation |
Maciejewski, Jaroslaw | Hematology and pathophysiology of hematologic diseases including bone marrow failure syndromes (BMFS) |
Manor, Danny | Signal transduction pathways that regulate normal cell growth and that are disrupted by oncogenic mutations. Molecular mechanisms by which some chemo-preventative agents, such as vitamin E, offer protection from cancer. |
Markowitz, Sanford | Molecular biology of colon cancer; functional influence of oncogenes and suppressor genes on transformation, metastasis, and response to therapies |
Matsuyama, Shigemi | Cancer Cell Biology, Cell Death Regulation, Cell Penetrating Peptide |
McCandless, Shawn | Management of inborn errors of metabolism, Prader-Willi syndrome |
McDermott, Brian | Neurobiology of the auditory hair cell: From functional analyses of mechanotransduction and synaptic transmission to its development and its role in deafness using the zebrafish model system |
McDonald, David | Direct visualization of intra- and intercellular trafficking of the Human Immunodeficiency Virus |
McIntyre, Thomas | Role of signaling molecules, particularly lipids, that control and modulate rapid cellular interactions and intracellular functions in human inflammation. Enzymes that make and inactivate lipid signaling molecules, and their roles in human disease. |
Mears, Jason | Structure and function of eukaryotic proteins that regulate mitochondrial dynamics. Cryo-electron microscopy, biochemical and computational methods |
Medof, M. Edward | T cell immunology, autoimmunity, and T regulatory function; cancer immungens; growth factors and apoptosis; ocular immunology; the connection between complement and neurobiology |
Merrick, William | Mechanism and regulation of eukaryotic protein biosynthesis |
Mieyal, John | Enzymatic reaction mechanisms involved in intracellular sulfhydryl homeostasis and redox signaling pertinent to diseases involving oxidative stress and inflammation, including cardiovascular and neurodegenerative diseases and cancer |
Miller, Robert | Developmental neurobiology, glial function, CNS pattern formation |
Min, Booki | Homeostatic regulation of T lymphocytes |
Moiseenkova-Bell, Vera | Molecular mechanisms and structural basis of pain and temperature sensation (structure-functional analysis of TRP and 2PK channels). Cryo-electron microscopy and X-ray crystallography. |
Monnier, Vincent | Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology |
Montano, Monica | Mechanism of action of estrogens and antiestrogens in cancer. |
Morton, Richard | Lipid and lipoprotein metabolism, cholesterol homeostasis, regulation of adipocyte lipid storage |
Nagy, Laura | Basic and translational research in the role of innate immunity in liver disease; adipose/liver/gut interactions in liver injury |
Narla, Goutham | Transcriptional regulation of oncogene signaling; mouse models of cancer metastasis; small molecule based drug discovery; alternative RNA splicing in cancer metastasis; signal transduction and the role of transcription factors and protein phosphatases in oncogene signaling |
Nguyen, Liem | Interactions of pathogenic mycobacteria with host immune systems. Antibiotic resistance, pathogenesis, cell wall assembly and cell division control in Mycobacterium tuberculosis |
Nieman, Marvin | Mouse models of thrombosis, platelet signaling, protease-activated receptors |
Nilsen, Timothy | RNA processing and transcription in nematodes. Homologous cell free systems are used to dissect in detail the mechanisms of cis- and trans-splicing as well as the transcription of UsnRNA genes |
Noy, Noa | Mechanisms of action and biological functions of nuclear hormone receptors |
Oleinick, Nancy | Ionizing, radiation damage, chromatin structure, nuclear matrix of photosensitization-induced apoptosis, signal transduction, photodynamic therapy |
Palczewski, Krzysztof | Mechanism of rhodopsin functions, rods and cones in the eye, phototransduction |
Park, Paul | Mechanism of action of rhodopsin and other G protein-coupled receptors |
Pearlman, Eric | Inflammation, innate immunity and infectious diseases in the eye |
Pehek, Elizabeth | Neuropharmacology and neurochemistry of brain pathways implicated in the regulation of mood, cognition, and reward. |
Pikuleva, Irina | Cholesterol metabolism; Alzheimer's disease; age-related macular degeneration; biochemical, structural, mass-spectrometry, and in vivo studies of cholesterol-metabolizing cytochromes P450 |
Qu, Cheng-Kui | Cell signaling mechanisms in hematopoietic stem cells and leukemia stem cells |
Ramachandran, Rajesh | Molecular mechanisms of membrane remodeling, fission and fusion in synaptic vesicle endocytosis and mitochondrial dynamics |
Ramirez-Bergeron, Diana | Cardiovascular stem cells and development |
Ransohoff, Richard | Functions of chemokines and chemokine receptors in development and pathology of the nervous system |
Religa, Tomasz | Analysis of chaperone-assisted protein folding using biophysical tools, NMR, computational and biochemical methods |
Rietsch, Arne | Bacterial pathogenesis; virulence gene regulation and structure-function analysis of toxin secretion systems in Pseudomonas aeruginosa |
Ritzmann, Roy | Sensory-motor integration, cockroach, electrophysiology, modeling. |
Romani, Andrea | Hormonal regulation of cellular magnesium homeostasis and transport in liver cells under physiological conditions and in pathological diseases including diabetes and alcoholism |
Runge, Kurt | Regulation of the length of telomere repeats and their role in cell physiology; Genetic pathways controlling gene silencing and cell aging. |
Sabo, Shasta | Formation of synapses between CNS neurons. |
Safar, Jiri | Protein misfolding, structure-function correlations, amyloid immunochemistry, age-related neurodegeneration, transgenic mice therapeutics, translational medicine, prion diseases, Alzheimer’s disease |
Salz, Helen | Regulation of RNA Splicing; Drosophila Sex Determination |
Scacheri, Peter | Genomics of cancer and other genetic diseases with underlying defects in chromatin structure and function |
Schiemann, William | Role of TGF-ß signaling, epithelial plasticity, and mechanotransduction in regulating breast cancer development and metastatic progression |
Schilling, William | Molecular mechanisms associated with agonist-induced Ca2+ signaling in mammalian non-excitable cells and in particular, in vascular endothelial cells and renal epithelial cells |
Schmaier, Alvin | Vascular biology of the kallikrein/kinin and renin angiotensin systems, examining the proteins prolylcarboxypeptidase, prekallikrein, factor XII, & high molecular weight kininogen. Development of an anti-platelet drug for heart attacks that is a thrombin and PAR 1 and 4 activation antagonist |
Sedwick, W. David | Mutational specificity at DNA sequence level, DNA damage and drug access, DNA repair, genetic susceptibility to cancer, colon cancer, mutagens and their specificity |
Sen, Ganes C. | Mammalian gene expression of angiotensin-converting enzyme and interferon; Mechanism of interferon action |
Sieg, Scott | Immune dysfunction in HIV disease; mucosal defensins and adaptive immunity; chronic immune activation in HIV disease |
Silver, Jerry | Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance |
Silverman, Robert | Molecular mechanisms of the antitumor and antiviral activities of interferons |
Singh, Neena | Prion diseases, protein transport, chaperones, proteasomes, nuclear import |
Skowronski, Jacek | HIV-host cell interaction, accessory proteins |
Smith, Corey | Mechanism by which chromaffin cells differentially release cargos in an activity-dependent manner |
Smith, Jonathan | Cholesterol metabolism by macrophages. Genetics of atherosclerosis susceptibility in mouse models. Genetics and drug discovery in mouse models of Alzheimer disease. |
Stamler, Jonathan | Redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation |
Stelzer, Julian | Cellular and molecular mechanisms of muscle contraction in the development of hypertrophic and dilated cardiomyopathy |
Stewart, Phoebe | Structural characterization of macromolecular complexes by cryo-electron microscopy and hybrid methods |
Strowbridge, Ben | Synaptic physiology, hippocampus, olfactory bulb, computational neuroscience. |
Subauste, Carlos | Immunology, cell signaling in host-pathogen interactions, Toxoplasma, HIV, autophagy, selective blockade of CD40 signaling to control disorders such as atherosclerosis and microvascular complications of diabetes |
Surewicz, Witold | Aging; diseases of protein conformation; amyloid; prion disease; prion protein; Alzheimerís disease; molecular chaperones; heat shock proteins; cataract; protein chemistry; protein folding; protein-membrane interactions; biophysical chemistr |
Sy, Man-Sun | Transmissible spongiform encephalopathy, prion diseases |
Tartakoff, Alan | Dynamic spatial relations in eukaryotic cells and development of genetic strategies to combat disease |
Taylor, Derek | Telomere maintenance and mRNA regulation. Macromolecular structure and function, primarily using electron microscopy |
Tesar, Paul | Stem cell pluripotency and differentiation; developmental neurobiology; developmental genetics |
Tilton, John | Cellular factors that regulate susceptibility of cells to HIV infection. Defining the subsets of CD4+ T cells that are infected by HIV. |
Tochtrop, Gregory | Linkage between oxidative stress pathways and lipid peroxidation. Role of the fatty acid binding protein family in lipid signaling |
Trapp, Bruce | Cellular and Molecular Biology of Myelination, Demyelination, and Dysmyelination |
Valadkhan, Saba | Mechanism of splicing. Determining if RNA molecules, which were the primordial catalysts in living systems, still retain catalytic function in the spliceosome, the largest cellular machine in modern eukaryotes. |
Van Den Akker, Focco | Structural biology; infectious diseases/antibiotic resistance; cardiovascular diseases; small-molecule therapeutics design; cell signaling |
Veigl, Martina | DNA repair, mutation analysis in bacterial and mammalian gene targets, mutagenic effects of nucleotide pool imbalance, colon cancer, genetic susceptibility, environmental mutagens |
von Lintig, Johannes | Role of retinoids in processes ranging from development to vision, cell proliferation and metabolic control. |
Wang, Bing-cheng | Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides. |
Wang, John | Role of protein tyrosine phosphatases in cancer; chromosomal instability in cancer. |
Wang, Qing | Human genetics, angiogenesis, development and regulation of the cardiovascular system, electrophysiology, calcium signaling, apoptosis, and gene expression |
Ward, Nicole | Development of the neural and vascular systems; angiogenesis; neurogenesis; mouse molecular genetics; angiopoietins; vascular endothelial growth factors; neurotrophins |
Watanabe, Michiko | Heart Development, cardiogenesis, apoptosis, cell signaling, coronary vessel development, lymphagiogenesis, cardiac conduction system |
Weiss, Michael | Structural mechanisms of human diseases; Transcriptional deregulation and protein misfolding with applications to diabetes and disorders of sexual development |
Welford, Scott | Regulation of cell senescence and radiation resistance by normal and pathological tissue hypoxia in cancer initiation, progression, and therapy |
Wesson, Dan | Olfaction, Alzheimer's disease, Behavior,Electrophysiology, Amyloid-beta, Sniffing behavior, Multi-sensory integration |
Willis, Mark | Neural basis of adaptive behavior. Odor-guided navigation and flight in insects. |
Wise, Jo Ann | Mechanism and regulation of pre-mRNA splicing, RNA-protein interactions, fission yeast genetics |
Wood, Debra | Modulation of small neural networks, peptide function and second messenger systems, behavior and biomechanics of feeding in crabs. |
Yang, Sichun | Structure and function of nuclear estrogen receptors (ERs); small-angle X-ray solution scattering (SAXS); computational biophysics and molecular simulation; conformation-based ligand screening |
Yang, Yu-Chung | Cytokine signal transduction; transcription factors; hematopoiesis |
Yee, Vivien | Determination of protein molecular structure using X-ray diffraction and correlation with function. |
Zhang, Guofang | Understanding of metabolic disturbances that occur during oxidative stress |
Zhang, Junran | Repair of DNA double strand breaks. Role of repair in protection against carcinogenesis by maintaining genomic stability. Sensitization of tumor cells to radiation and chemotherapeutic drugs by interruption of DNA double strand break repair |
Zhang, Youwei | Molecular mechanisms of DNA damage and replication checkpoint control and their potential in cancer therapy |
Zheng, Qing | Genes and molecular pathways that are involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome |
Zhou, Guang | Transcription factors that determine cell fate and regulate cell function during skeletogenesis and bone metastasis |
Zhou, Lan | Notch signaling in hematopoiesis; myeloid development; hematopoietic stem cells; fucosylglycans in cancer biology |
Zhu, Alan | Live imaging of the Hedgehog signal transduction in embryos and cultured cells; Regulating developmental signaling by vesicle trafficking; Sterol-sensing domain containing proteins in embryonic morphogenesis |
Zhu, Xiongwei | Neurodegeneration, Alzheimer disease, Amyotrophic lateral sclerosis, Oxidative stress, Signal transduction, Mitochondria, Cell cycle control |
Zigmond, Richard | Changes in neuronal gene expression after injury. |
Zimmerman, Peter | Influence of human and parasite genetic polymorphism on pathogenesis of infectious diseases |
Zou, Wenquan | Protein aggregation in the conformational diseases especially on the physiological and pathologic prion proteins |