Markowitz Colon Cancer Laboratory

Our mission is to identify key genetic causes of colon cancer and to develop better ways for prevention, early detection, and treatment of this disease.

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1.  Markowitz S, Marchesi VT:  The carboxyl-terminal domain of human erythrocyte band 3:  description, isolation and location in the bilayer.  J Biol Chem 256: 6463-6468, 1981.

 2.  Melnick D, Nauseef W, Markowitz S, Gardner J, Malech H:  Biochemical analysis and subcellular localization of a neutrophil specific antigen, PMN-7, involved in the respiratory burst.  J Immunol 134: 3346-3355, 1985.

 3.  Todd MB, Malech HL, Waldron JA, Jennings KJ, Rome LS, Markowitz SD, Holford TR, Gardner JP, Wolak JP:  Loss of myeloid differentiation antigens is correlated with impending blast transformation in chronic myelogenous leukemia.  Blood 70: 122-131, 1987.

 4.  Markowitz S, Krystal G, Lebacq-Verheyden A, Way J, Sausville E, Battey J:  Transcriptional activation and DNAse I hypersensitive sites are associated with selective expression of the gastrin-releasing peptide gene.  J Clin Invest 82: 808-815, 1988.

 5.  Battey JF, Labacq-Verheyden AM, Krystal G, Markowitz S, Sartor O, Way J:  Regulation of the expression of human pre-progastrin-releasing peptide gene and post-translational processing of its gene product.  Ann  NY Acad Sci 547: 30-40, 1988.

 6.  Markowitz S, Haut M, Stellato T, Gerbic C, Molkentin K:  Expression of the ErbA-Beta class of thyroid receptors is selectively lost in human colon carcinoma.  J Clin Invest 84: 1683-1687, 1989.

 7.  Markowitz S, Molkentin K, Gerbic, Jackson J, Stellato T, Willson J:  Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor receptor in normal and adenomatous human colon epithelium.  J Clin Invest 86: 356-362, 1990.

 8.  Baker S, Markowitz S, Fearon E, Willson J, Vogelstein B:  Wild-type p53 suppresses the growth of human colorectal carcinoma cells.  Science. 249: 912-915, 1990.

 9.  Baker S, Preisenger A, Jessup J, Paraskeva C, Markowitz S, Willson J, Hamilton S, Vogelstein B:  p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.  Cancer Res 50: 7717-7722, 1990.

10. Haut M, Steeg P, Willson J, Markowitz S:  Nm23 gene expression is induced in human colonic neoplasms and is equal in colon tumors of both high and low metastatic potential.  J Natl Cancer Inst 83: 712-716, 1991.

11. Myeroff L, Markowitz S:  Colon carcinomas of both high and low metastatic potential demonstrate increased expression and the absence of mutations in the nm23-H1 and nm23-H2 genes. J Natl Cancer Inst 85: 147-152, 1993.

12. Smith K, Johnson K, Bryan T, Hill D, Markowitz S, Willson J, Paraskeva C, Petersen G, Hamilton S, Vogelstein B, Kinzler K:  The APC gene product in normal and tumor cells.  Proc Natl Acad Sci (USA) 90: 2846-2850, 1993.

13. Leach F, Elledge S, Sherr C, Willson J, Markowitz S, Kinzler K, Vogelstein B:  Amplification of cyclin genes in colorectal carcinomas.  Cancer Res 53: 1986-1989, 1993.

14. Markowitz SD, Myeroff L, Cooper MJ, Traicoff J, Kochera M, Lutterbaugh J, Swiriduk M, Willson JKV:  A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.  J Clin Invest 93: 1005-1013, 1994.

15. Pietenpol JA, Papadopoulos N, Markowitz S, Willson JKV, Kinzler KW, Vogelstein B:  Paradoxical inhibition of solid tumor cell growth by bcl2.  Cancer Res 54: 3714-3717, 1994.

16. Liu B, Parsons RE, Hamilton SR, Peterson GM, Lynch HT, Watson P, Markowitz, S, Willson JKV, Green J, de  la Chappelle A, Kinzler KW, Vogelstein B:  hMSH2 mutations in hereditary non-polyposis colorectal cancer kindreds.  Cancer Res 54: 4590-4594, 1994.

17. Jen J, Harper JW, Bigner SH, Papadopoulos N, Markowitz S, Willson JKV, Kinzler KW, Vogelstein B:  Deletion of p16 and p15 genes in brain tumors.  Cancer Res 54: 6553-6358, 1994.

18.  Liu B, Nicolaides NC, Markowitz, S, Willson JKV, Parsons RE, Jen J, Papadopoulos N, Peltomäki P, de la Chappelle A, Hamilton S, Kinzler K, Vogelstein B:  Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet  9: 48-55, 1995.

19.  da Costa LT, Liu B, El-Deiry WS, Hamilton SR, Kinzler KW, Vogelstein B, Markowitz S, Willson

      JKV, de la Chappelle A, Downey K, So A:  Polymerase d variants in RER colorectal tumours.  Nature

      Genet 9: 10-11, 1995.

20. Eshleman JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B, Willson JKV, Veigl ML, Sedwick WD, Markowitz S:  Increased Mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.  Oncogene.  10: 33-37, 1995.

21. Markowitz S, Hines JD, Lutterbaugh J, Myeroff  L, Mackay W, Gordon N, Rustum Y, Luna E, Kleinerman J:  Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy response or survival. Clin Cancer Res  1: 441-445, 1995.

22. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RW, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV:  Inactivation of the type II TGF-ß receptor in colon cancer cells with microsatellite instability.  Science 268: 1336-1338, 1995.   

23. Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JKV, Kinzler KW, Jiricny J, Vogelstein B: Mutations of GTBP in genetically unstable cells. Science 268: 1915-1917, 1995.  

24. Wang J, Sun L, Myeroff L, Wang X, Gentry LE, Yang J, Liang J, Zborowska E, Markowitz S, Willson JKV, Brattain MG:  Demonstration that mutation of the type II Transforming Growth Factor-ß receptor inactivates its tumor suppressor activity in Replication Error-positive colon carcinoma cells.  J Biol Chem 270: 22044-22049, 1995.

25. Wang CY, Eshleman JR, Willson JKV, Markowitz S:  Both Transforming Growth Factor-ß and substrate release are inducers of apoptosis in a human colon adenoma cell line.  Cancer Res 55: 5101-5105, 1995.

26. Riggins GJ, Markowitz S, Willson JK, Vogelstein B, Kinzler K:  Absence of secretory phospholipase A2 gene alterations in human colorectal cancer.  Cancer Res 55: 5184-5186, 1995.

27. Parsons R, Myeroff LL, Liu B, Willson JKV, Markowitz SD*, Kinzler KW, Vogelstein B:  Microsatellite instability and mutations of the TGF-ß type II receptor gene in colorectal cancer.  Cancer Res 55: 5548-5550, 1995. (*SM corresponding author)

28. Myeroff LL, Parsons R, Kim S-J, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J, Park K, Bang Y-J, Lee HY, Park J-G, Lynch HT, Roberts AB, Vogelstein B, Markowitz SD:  A TGF-beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.  Cancer Res  55: 5545-5547, 1995.

29. Eshleman JR, Markowitz SD, Donover PS, Lang EZ, Lutterbaugh JD, Li G-M, Longley M, Modrich P, Veigl ML, Sedwick WD:  Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.  Oncogene.  12:1425-1432, 1996.

30. Thiagalingam S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JKV, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B:  Evaluation of the FHIT gene in colorectal cancers.  Cancer Res. 56:2936-2939, 1996.

31. Thiagalingam S, Lengauer C, Leach F, Schutte M, Hahn S, Overhauser J, Willson JKV, Markowitz S, Hamilton S, Kern SE, Kinzler KW, Vogelstein B:  Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.  Nature Genet. 13:343-346, 1996.

32. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JKV, Markowitz SD, Kinzler KW, Vogelstein B:  Mad-related genes in the human.  Nature Genet. 13:347-349, 1996.

33. Yang B, Stambrook PJ, Markowitz SD:  Wild-type p53 demonstrates functional dominance in a human colon carcinoma cell line in which it induces reversible growth arrest.  Clin. Cancer Res.  2: 1639-1647, 1996.

34. Yang B, Eshleman JR, Berger NA, Markowitz SD:  Wild-type p53 protein potentiates cytotoxicity of therapeutic agents in human colon cancer cells.  Clin. Cancer Res. 2: 1649-1657, 1996.

35. Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson JKV, Markowitz SD, Morin P, Kinzler KW, Vogelstein B, Dunlop MG:  APC mutations in colorectal tumors with mismatch repair deficiency.  Proc. Natl. Acad. Sci. (USA) 93: 9049-9054, 1996.

36. Liu D, Pearlman E, Diaconu E, Guo K, Mori H, Markowitz S, Willson J, Sy M:  Human tumor cells express a hyaluronidase gene which can induce angiogenesis in vivo.  Proc. Natl. Acad. Sci. (USA).  93:7832-7837, 1996

37. Liu L, Markowitz S, Gerson SL:  Mismatch repair mutations override alkytransferase in conferring resistance to temozolomide but not 1,3 bis(2-chloroethyl)nitrosourea.  Cancer Res. 56:5375-5379, 1996.

38. Wu GS, Burns TF, McDonald ER III, Jinag W, Meng R, Krantz ID, Kao G, Gan D-D, Zhou J-Y, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G and El-Deiry WS:  Killer/DR5 is a DNA damage-inducible p53-regulated death receptor gene.  Nature Genet. 17:141-143, 1997.

39.  Phillips Jr W, Willson JKV, Markowitz S, Zborowska E, Zaidi N, Liu L, Gordon N, and Gerson S: 06-Methylguanine-DNA Methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogeneous MGMT+/MGMT- xenografts after BCNU and 06-benzylguanine plus BCNU.  Cancer Res.  57: 4817-4823, 1997

40.  Eshleman JR, Donover PS, Littman S,J Swinler SE, Li G-M, Lutterbaugh JD, Willson JKV, Modrich P, Sedwick WD, Markowitz SD, and Veigl ML: Increased transversions in a novel mutator colon cancer cell line.  Oncogene.  16:1125-1130, 1998.

41.  Cahill DP, Lengauer C, Yu  J, Riggens GJ, Willson JKV, Markowitz SD, Kinzler KW and Vogelstein B.  Mutations of mitotic checkpoint genes in human cancers.  Nature.  392:300-303, 1998.

42. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa J-PJ, Markowitz S, Willson JKV, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA , Baylin SB:  Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA. 95:6870-6875, 1998.

43. Veigl ML, Kasturi L, Olechnowicz J, Ma A, Lutterbaugh JD, Periyasamy S, Li G-M, Drummond J, Modrich PL, Sedwick WD , Markowitz SD:  Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci (USA). 95:8698-8702, 1998.

44. Grady WM, Rajput A, Myeroff L, Liu DF, Kwon K , Willis J, Markowitz S:  Mutation of the type II Transforming Growth Factor-ß receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res.58:3101-3104, 1998.

45.  Eshleman JR, Casey G, Kochera ME, Sedwick WD, Swinler SE, Veigl ML, Willson JKV, Schwartz S , Markowitz SD:  Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53. Oncogene.  17:719-725, 1998.

46.  Polyak K, Yunbo L, Hong Z, Lengauer C, Willson JKV, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B:  Somatic mutations of the mitochondrial genome in human colorectal tumours.  Nature Genetics.  20:291-293, 1998

47.  Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim S-J, Kinzler KW, Vogelstein B, Willson JKV, Markowitz S.  Mutational inactivation of Transforming growth factor b receptor type II in microsatellite stable colon cancers.  Cancer Res.  59:320-324, 1999. 

48.  Guilford PJ, Hopkins JBW, Grady WM, Markowitz SD, Willis J, Lynch H, Rajput A, Wiesner GL, Lindor HM, Burgart LJ, Toro TT, Lee D, Limacher J-M, Shaw DW, Findlay MPN, Reeve AE.  E-Cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Hum Mutat. 14:2499-255, 1999.

49.  Chen W-D, Eshleman JR, Aminoshariae, MR, Ma A-H, Veloso N, *Markowitz SD, Sedwick WD, Veigl, ML.  Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells.  J Natl Cancer Inst. 92: 480-485, 2000. (*SM corresponding author)

50.  Yan H, Papadopoulos N, Marra G, Perrera C, Jiricny J, Boland CR, Lynch HT, Chadwick RB, de la Chapelle A, Berg K, Eshleman JR, Yuan W, Markowitz S, Laken SJ, Lengauer C, Kinzler KW, Vogelstein B.  Conversion of diploidy to haploidy.  Nature.  403:723-724, 2000.

51.  Ma A-H, Xia L, Littman SJ, Swinler S, Lader G, Polinkovsky A, Olechnowicz J, Kasturi L, Lutterbaugh J, Modrich P, Veigl ML, Markowitz SD, Sedwick WD.  Somatic mutation of hPMS2 as a cause of sporadic human colon cancer with Microsatellite instability.  Oncogene.  19:2249-2256, 2000.

52.  Pretlow T, Schwartz S, Giaconia J, Wright A, Grimm H, Edgehouse N, Murphy J, Markowitz S, Jamison J, Summers J, Hamlin C, MacLennan G, Resnick M, Pretlow T, Connell C: Prostate cancer and other xenografts from cells in peripheral blood of patients. Cancer Res. 60:4033-4036, 2000.

53.  Grady W, Willis J, Guilford P, Dunbier A, Toro T, Lynch H, Wiesner G, Ferguson K, Eng C, Park JG, Kim SJ, Markowitz, S: Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genet 26:16-17, 2000.

54.  Lynch H, Grady W, Lynch J, Tsuchiya K, Wiesner G, Markowitz S: E-Cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma. Cancer Genet Cytogenet , 122:1-6, 2000.

55.  Fink S, Swinler S, Lutterbaugh J, Massague J, Thiagalingam S, Kinzler K, Vogelstein B,

Willson J , Markowitz S: Transforming growth factor-beta induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res. 61:256-260, 2001.

56.  Grady Wm, Rajput A, Lutterbaugh JD, Markowitz SD.  Detection of Aberrantly Methylated hMLH1 promotor DNA in the serum of patients with microsatellite unstable colon cancer.  Cancer Res. 61:900-902, 2001.

57.  Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B , Lengauer C: Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A. 98:2698-2702., 2001.

58.  Wiesner G, Platzer P, Buxbaum S, Lewis S, MacMillen M, Olechnowicz J, Willis J, Chakravarti A, Elston R , Markowitz S: Testing for Colon Neoplasia Susceptibility Variants at the Human COX2 Locus. J Natl Cancer Inst. 93:635-639, 2001.

59.  Forgacs E, Wren JD, Kamibayashi C, Kodo M, Xu XL, Markowitz S, Tomlinson GE, Muller CY,

Gazdar AF, Garner HR, Minna JD:  Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.  Oncogene. 20:1005-1009, 2001.

60.  Zhang L, Yu J, Willson JKV, Markowitz S, Kinzler K , Vogelstein B: Short mononucleotide repeat

sequence variability in mismatch repair deficient cancers. Cancer Res. 61:3801-3805, 2001.

61.  Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY, Green J, Kim SJ.  Loss of transforming growth factor beta signaling in the intestine contributes to tissue injury in inflammatory bowel disease.  Gut.  49(2)190-198, 2001.

62.  Zhou  H, Chen WD, Qin X, Lee K, Liu L, Markowitz SD, Gerson SL.  MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice.  Oncogene.  20(42):6009-6017, 2001. 

63.  Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci U S A 99:3076-80, 2002.

64.  Platzer P, Upender MB, Wilson K, Willis J, Lutterbaugh J, Nosrati A, Willson JK, Mack D, Ried T, Markowitz S. Silence of chromosomal amplifications in colon cancer. Cancer Res 62(4):1134-8,2002.

65.  Li H, Myeroff L, Kasturi L, Krumroy L, Schwartz S, Willson JK, Stanbridge E, Casey G, Markowitz S. Chromosomal autonomy of hMLH1 methylation in colon cancer. Oncogene 21(9):1443-9 2002.

66.  Yan H, Dobbie Z, Gruber SB, Markowitz S, Romans K, Giardiello FM, Kinzler KW, Vogelstein B. Small changes in expression affect predisposition to tumorigenesis. Nat Genet  30(1):25-6, 2002

67.  Zawel L, Yu J, Torrance C J, Markowitz S, Kinzler KW, Vogelstein B, and Zhou S. DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities, Proc Natl Acad Sci U S A 99:2848-2853, 2002.

68.  Moinova HR, Chen WD, Shen L, Smiraglia D, Olechnowicz J, Ravi L, Kasturi L, Myeroff L, Plass C, Parsons R, Willson J, Green S, Issa J, Markowitz S: HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A 99:4562-67, 2002.

69.  Fink S., Mikkola D., Willson J., Markowitz S: TGF-ß-Induced Nuclear Localization of Smad2 and Smad3 in Smad4 Null Cancer Cell Lines. Oncogene 22: 1317-23, 2003.

70.  Brunschwig E, Wilson K, Mack D, Dawson DM, Lawrence E, Wilson JKV, Lu S, Nosrati A, Swinler S, Beard L, Lutterbaugh J, Willis J, Platzer P, Markowitz S. PMEPA1, a TGF-beta induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. Cancer Res 63: 1568-75, 2003.

71.  Hempen PM, Zhang L, Bansal RK, Iacobuzio-Donahue CA, Murphy KM, Maitra A, Vogelstein B, Whitehead RH, Markowitz SD, Willson JKV, Yeo CJ, Hruban RH, Kern SE. Evidence of selection for clones having genetic inactivation of the activin A type II receptor gene in gastrointestinal cancers. Cancer Res 63: 994-99, 2003.

72.  Bardelli A, Parsons W, Silliman N, Ptak J, Szabo S, Saha S, Markowitz S, Willson J, Parmigiani G, Kinzler K, Vogelstein B , Velculescu V. Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers. Science 300:949, 2003.

73.  Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Casey G, Issa J-P, Willis J, Willson JKV, Plass C, Markowitz SD. SLC5A8: A novel sodium transporter, is a tumor suppressor gene silenced by methylation in human colonic aberrant crypt foci and colon cancers. Proc Natl Acad Sci U S A 100: 8412-17, 2003.

74.  Wiesner G, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh J, MacMillen M, Baliner B, Willis J, Elston R.C, Markowitz SD.  A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2 Proc Natl Acad Sci U S A 100: 12961-65, 2003.

75.  Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B.  PRL-3 expression in metastatic cancers.  Clin Cancer Res 9:5607-5615, 2003.

76.  Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK.  Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability.  Oncogene 23:639-645, 2004.

77.  Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen W-D, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB.  Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.  Nat Genet 36:417-22, 2004. 

78.  Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE.  High frequency of mutations of the PIK3CA gene in human cancers.  Science 304:554, 2004.

79.  Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, Karess R, Kinzler KW, Vogelstein B, Velculescu VE, Lengauer C.  Three classes of genes mutated in colorectal cancers with chromosomal instability.  Cancer Res 64:2998-3001, 2004.

80.  Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, Van Der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE.  Mutational analysis of the tyrosine phosphatome in colorectal cancers.  Science 304:1164-1166, 2004.

81.  Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD.  C8orf4 is a transforming growth factor ß induced transcript downregulated in metastatic colon cancer.  Int J Cancer 111:72-75, 2004.

82.  Coady MJ, Chang MH, Charron FM, Plata C, Wallendorff B, Sah JF, Markowitz SD, Romero MF, Lapointe JY.  The human tumor suppressor gene SLC5A8 expresses a Na+/monocarboxylate cotransporter.  J Physiol 557:719-731, 2004.

83.  Yan M, Rerko R, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson J,  Luo G, Hensold J, Tai H, Wilson K, Markowitz, S. 15-Hydroxyprostaglandin Dehydrogenase, a COX-2 oncogene antagonist, is a TGF-ß induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A 101:17468-17473, 2004.  {Chosen as a “From The Cover” Article by PNAS; and profiled in “Research Highlights” in Nature Reviews Cancer 5(1):5, 2005}.

84.  Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz, S. Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia. Oncogene 24(4):724-731, 2005.

85.  Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady, WM. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res;11:1203-1209, 2005.

86.  Chen W-D, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Katuri L, Willson JKV, Rao JS, Shuber A, Markowitz SD.  Detection in fecal DNA of colon cancer-specifc methylation of the nonexpressed vimentin gene. J Natl Cancer Inst. 97: 1124-1132, 2005.

87.  Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins J, DeLong L, Silliman N, Ptak J, Szabo S, Willson JKV, Markowitz S, Kinzler K, Vogelstein B, Lengauer C, Velculescu V.  Colorectal Cancer: Mutations in a signaling pathway.  Nature 436: 792, 2005. 

88.  Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Gautam S, Markowitz SD. Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int J Cancer  118(3):600-8, 2006

89.  Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 45(8):781-9, 2006

90.  Sun X, Liu Y, Lutterbaugh J, Chen WD, Markowitz SD, Guo B. Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers. Clin Cancer Res 12(2):454-93, 2006

91.  Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. J Cell Biol 175(5):703-8, 2006

92.  Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A 103(32):12098-102, 2006.

93.  Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber T, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The Consensus Coding Sequences of Human Breast and Colorectal Cancers. Science  314:268-74, 2006.

94.  Kann L, Han J, Ahlquist D, Levin T, Rex D, Whitney D, Markowitz S, Shuber A. Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia. Clin Chem 2006;52(12):2299-302.

95.  Itzkowitz SH, Jandorf L, Brand R, Rabeneck L, Schroy PC, 3rd, Sontag S, Johnson D, Skoletsky J, Durkee K, Markowitz S, Shuber A. Improved Fecal DNA Test for Colorectal Cancer Screening. Clin Gastroenterol Hepatol 5(1):111-117, 2007.

96.  Guda K, Natale L., Markowitz S. An improved method for staining cell colonies in clonogenic assaysCytotechnology. 54(2): 85–88, 2007.

97.  Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. The Genomic Landscapes of Human Breast and Colorectal Cancers. Science 318:1108-13, 2007.

98.  Daley D, Morgan W, Lewis S, Willis J, Elston RC, Markowitz SD, Wiesner GL. Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia? Cancer Epidemiol Biomarkers Prev16(5):892-4, 2007.

99.  Zhang X, Guo C, Chen Y, Shulha H, Schnetz M, LaFramboise T, Bartels C, Markowitz S, Weng Z, Scacheri P, Wang Z.  Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.  Nature Methods 5:163-165, 2008. PMCID: PMC2435063

100.                      Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim YH, Tsuchiya KD, Washington MK, Paraskeva C, Willson JKV, Kaz AM, Kroh EM, Bllen A, Fritz BR, Markowitz SD, Tewari M.  Epigenetic silencing of the intronic microRNA has-miR-342 and its host gene EVL in colorectal cancer.  Oncogene 27:3380-3388, 2008.

101.                      Biswas S, Trobridge P, Romero-Gallo J, Billheimer D, Myeroff L, Willson JKV, Markowitz S, Grady W.  Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor ß resistant cells.   Genes Chromosomes and Cancer 47: 95-106, 2008.

102.                      Daley D, Lewis S, Platzer P, MacMillen M, Willis J, Elston RC, Markowitz S, Wiesner G.  Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study.  American Journal of Human Genetics 82: 732-736, 2008. PMCID: PMC2427227

103.                      Jones S, Chen WD, Diehl F, Parmigiani G, Beernwinkel N, Antal T, Traulsen A, Nowark M, Siegel C, Velculescu V, Kinzler K, Vogelstein B, Willis J, Markowitz SD. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 105:4283-4288, 2008. PMCID: PMC2393770

104.                      Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, Walbroehl J, Lowenberg E, Golub T, Merchan J, Tenen DG, Markowitz SD, Halmos B. 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res 68(13):5040-8, 2008.

PMCID: PMC2265152

105.                      Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A 105(9):3443-8, 2008. PMCID: PMC2265152

106.                      Rojas A, Meherem S, Kim YH, Washington MK, Willis JE, Markowitz SD, Grady WM. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer 123(1):14-21, 2008. PMCID:PMC2777657

107.                      Itzkowitz S, Brand R, Jandorf L, Durkee K, Millholland J, Rabeneck L, Schroy PC, 3rd, Sontag S, Johnson D, Markowitz S, Paszat L, Berger BM. A simplified, noninvasive stool DNA test for colorectal cancer detection. Am J Gastroenterol;103(11):2862-70, 2008.

108.                      Hughes D, Otani T, Yang P, Newman R, Yantiss R, Altorki N, Port J, Yan M, Markowitz S, Mazumdar M, Tai H, Subbaramaiah K, Dannenberg A. NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer. Cancer Prevention Research 1:241-249, 2008. PMCID: PMC2720569

109.                      Guo C, Sah JF, Beard L, Willson JK, Markowitz SD*, Guda K. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47(11):939-46, 2008. (*SM corresponding author) PMCID: PMC2739997

110.                      Guo C, Zhang X, Fink SP, Platzer P, Wilson K, Willson JK, Wang Z, Markowitz SD. Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. Cancer Res 68(15):6118-26, 2008. PMCID: PMC2614906

111.                      Motegi A, Liaw HJ, Lee KY, Roest HP, Maas A, Wu X, Moinova H, Markowitz SD, Ding H, Hoeijmakers JH, Myung K. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A 105(34):12411-6, 2008. PMCID: PMC2518831

112.                      Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjoblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A 105(42):16224-9, 2008. PMCID: PMC2571022

113.                      Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD. 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A 106(23):9409-13, 2009. PMCID: PMC2695050

114.                      Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner SM, Tomsic J, Valle L, de la Chapelle A, Elston RC, Willis J, Markowitz SD. Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res 69(12):4959-61, 2009.
PMCID: PMC2739986

115.                      Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H, Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson KC, Carrasco DR.  BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. Cancer Res.  69(19):7577-86 2009.

116.                      Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JK, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, Velculescu VE, Kinzler KW, Papadopoulos N, Vogelstein B, Willis J, Gerken TA, Markowitz SD. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc Natl Acad Sci U S A 106(31): 12921-5, 2009. PMCID: PMC2722285

117. Li M, Chen WD, Papadopoulos N, Goodman SN, Bjerregaard NC, Laurberg S, Levin B, Juhl H, Arber N, Moinova H, Durkee K, Schmidt K, He Y, Diehl F, Velculescu VE, Zhou S, Diaz LA, Jr., Kinzler KW, Markowitz SD*, Vogelstein B. Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol 27(9):858-63, 2009. (*SM Corresponding Author). PMCID: PMC2847606


118. Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Jr., Velculescu V, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells. Science 325:1555-1559, 2009. PMCID: PMC2820374


119.  Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Dawson D, Willis J, Markowitz SD, Satake M, Wang Z.  Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A 107:2592-2597, 2010. PMCID: PMC2838211


120. Sun X, Elston R, Barnholtz-Sloan J, Falk G, Grady WM, Kinnard M, Mittal SK, Willis JE, Markowitz S, Brock W, Chak A. A segregation analysis of Barrett's esophagus and associated adenocarcinomas. Cancer Epidemiol Biomarkers Prev 19(3):666-74, 2010. PMCID: PMC2838211


121. He Y, Wu J, Dressman DC, Iacobuzio-Donahue C, Markowitz SD, Velculescu VE, Diaz LA, Kinzler KW, Vogelstein B, Papadopoulos N. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature 464(7288):610-4, 2010. PMCID: PMC3176451


122.  Gray-McGuire C, Guda K, Adrianto I, Lin CP, Natale L, Potter JD, Newcomb P, Poole EM, Ulrich CM, Lindor N, Goode EL, Fridley BL, Jenkins R, Le Marchand L, Casey G, Haile R, Hopper J, Jenkins M, Young J, Buchanan D, Gallinger S, Adams M, Lewis S, Willis J, Elston R, Markowitz SD, Wiesner GL. Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. Cancer Res. 70(13):5409-18, 2010. PMCID: PMC2896448.


123.  Tomsic J, Guda K, Liyanarachchi S, Hampel H, Natale L, Markowitz SD, Tanner SM, de la Chapelle A. Allele-specific expression of TGFBR1 in colon cancer patients. Carcinogenesis. 31(10):1800-4, 2010. PMCID: PMC2950937.


124.  Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao HY, Xu Y, Willis J, Markowitz SD, Sedwick D, Ewing RM, Wang Z. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal. 3(146):ra80, 2010. PMCID: PMC3116231


125.  Gerken TA, Jamison O, Perrine CL, Collette JC, Moinova H, Ravi L, Markowitz SD, Shen W, Patel H, Tabak LA. Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem. 286(16):14493-507, 2011. PMCID: PMC3077648.


126. Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A. 2011. PMCID:PMC3241824


127. Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N.  Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.  Hum Mutat 33:100-103, 2012.  PMCID: PMC3240719


128. Bulgar AD, Weeks LD, Miao Y, Yang S, Xu Y, Guo C, Markowitz S, Oleinick N, Gerson SL, Liu L.  Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.  Cell Death Dis 3:e252, 2012.  PMCID: PMC3270269


129. Dazard JE, Rao JS, Markowitz S.  Local sparse bump hunting reveals molecular heterogeneity of colon tumors.  Stat Med.  2011 Nov 3. doi: 10.1002/sim.4389 [Epub ahead of print]. PMCID: PMC3668571.


130. Chak A, Chen Y, Vengoechea J, Canto M, Elston R, Falk GW, Grady WM, Guda K, Kinnard M, Markowitz SD, Mittal SK, Prasad GA, Shaheen NJ, Willis JE, Barnholtz-Sloan JS.  Variation in age at cancer diagnosis in familial versus non-familial Barrett's esophagus.  Cancer Epidemiol Biomarkers Prev.  21(2):376-83, 2012. Epub 2011 Dec 16. PMCID: PMC3275661.


131. Leidner RS, Ravi L, Leahy P, Chen Y, Bednarchik B, Streppel M, Canto M, Wang JS, Maitra A, Willis J, Markowitz SD, Barnholtz-Sloan J, Adams MD, Chak A, Guda K.  The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis.  Genes Chromosomes Cancer.  51(5):473-9, 2012. Epub 2012 Feb 3. PMCID: PMC3547654.


132. Moinova HR, Leidner RS, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Chen Y, Chak A, Markowitz SD*, Willis JE.  Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies. Cancer Epidemiol Biomarkers Prev.  Apr;21(4):594-600, 2012.  (Journal Cover Article) (*SM corresponding author). PMCID: PMC3454489.


133. Akhtar-Zaidi B, Cowper-Sal-Iari R, Corradin O, Saiakhove A, Bartels C, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady M, Willis J, Moore J, Tesar P, Laframboise T, Markowitz SD, Lupien M, Scacheri P. Epigenomic enhancer profiling defines a signature of colon cancer.  Science. 336(6082):736-9, 2012.
doi: 10.1126/science.1217277. NIHMS: NIHMS488153.

134. Yu X, Guda K, Willis J, Veigl M, Wang Z, Markowitz S, Adams MD, Sun S. How do alignment programs          perform on sequencing data with varying qualities and from repetitive regions? BioData mining. 2012;5(1):6.          PMCID: PMC3414812.

135.Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE,          Sjoblom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD. Somatic mutations in CCK2R alter activity         that promote oncogenic phenotypes. Molecular cancer research : MCR. 10(6):739-49, 2012.

136. Balasubramanian D, Akhtar-Zaidi B, Song L, Bartels CF, Veigl M, Beard L, Myeroff L, Guda K, Lutterbaugh          J, Willis J, Crawford GE, Markowitz SD*, Scacheri PC*. H3K4me3 inversely correlates with DNA          methylation at a large class of non-CpG-island-containing start sites. Genome medicine. 4(5):47, 2102. (*SM          and *PS corresponding authors). PMCID: PMC3506913.

137. Adams MD, Veigl ML, Wang Z, Molyneux N, Sun S, Guda K, Yu X, Markowitz SD*, Willis J.* Global          mutational profiling of formalin-fixed human colon cancers from a pathology archive. Modern pathology :          official journal of the United States and Canadian Academy of Pathology, Inc. 25(12):1599-608, 2012.  (*SM             and *JW corresponding authors). NIHMS: NIHMS487159.

138. Zhang P, Guo A, Possemato A, Wang C, Beard L, Carlin C, Markowitz SD, Polakiewicz RD, Wang Z.                      Identification and functional characterization of p130Cas as a substrate of protein tyrosine  nonreceptor 14.          Oncogene. 2013 Apr 18:32(16):2087-95. PMCID: PMC3631434.

139. Ryu YM, Myung SJ, Park YS, Yang DH, Song HJ, Jeong JY, Lee SM, Song M, Kim do H, Lee HJ,         Park SK, Fink SP, Markowitz SD, Jung KW, Kim KJ, Ye BD, Byeon JS, Jung HY, Yang SK, Kim JH.  Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis. Cancer Prev Res (Phila). 2013 Apr;6(4):349-59. Epub 2013 Feb. 19. PMC Journal – in process.

140. Fink S, Yang DH, Barnholtz-Sloan J, Ryu YM, Mikkoloa D, Potter J, Lampe J, Markowitz S, Myung SJ. Colonic 15-PGDH Levels Are Stable Across Distance and Time and Are Not Perturbed by Aspirin Intervention. Dig Dis Sci. 2013 Apr 27. [Epub ahead of print]. NIHMSID: NIHMS473320.

141.Hao Y, Wang C, Cao B, Hirsch BM, Song J, Markowitz SD, Ewing RM, Sedwick D, Liu L, Zheng W,  Wang Z. Gain of interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions. Cancer Cell. 2013 May 13;23(5):583-93. NIHMS: NIHMS460332.

142.Thompson CL, Fink SP, Lutterbaugh JD, Elston RC, Veigl ML, Markowitz SD, Li L. Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One. 2013 May 22;8(5):e64122. PMCID: PMC3661460.


 1.  Markowitz S. Review of:  Cell and Molecular Biology of Colon Cancer.  Augenlicht, L. (ed.).  In: J Natl Cancer Inst 82: 523-524, 1990.

 2.  Markowitz S.  Molecular Biology of Colon Cancer.  Willson  J (ed).  In: Colorectal Cancer.  Cancer Center of the Medical College of Wisconsin Press, Milwaukee, WI 5-10, 1992.

 3.  Berger N, Willson J, Markowitz S, Levin B.  Colorectal cancer 1994:  Recent progress and future opportunities.  In: Public Education Committee, American Association Cancer Research  (Ed) Cancer Fact Sheets.  AACR, 1994.

 4.  Myeroff L. and Markowitz S.  Nm23--into the basement (membrane).  In: J Natl Cancer Inst 86: 1815-1817, 1994.

 5.  Eshleman J. and Markowitz S.  Microsatellite instability in inherited and sporadic human neoplasms.  In:  Current Opinion in Oncology.  7: 83-89, 1995.

 6.  Brattain M, Markowitz S, Willson JKV.  The type II TGF-beta receptor as a tumor suppressor gene.  In:  Current Opinion in Oncology.  8:49-53, 1996.

 7.  Markowitz S. and Roberts A.  Tumor suppressor activity of the TGF-beta pathway in human cancers.  In: Cytokine and Growth Factor Reviews.  7:93-102, 1996.

 8.  Eshleman J. and Markowitz S.  DNA repair defects in human carcinogenesis.  Hum. Molec. Genet.  5:1489-1494, 1996.

 9.  Grady W, Rajput A, Myeroff L, Markowitz S.  What's new with RII.  Gastroenterology.  112:297-302,  1997

10. Mucahy G, Goggins M, Decker R, Luce M, Parsons R, Markowitz S, Narod S, Holt J, Page D, Mauer A, Thor A.  The American Cancer Society's workshop on heritable cancer syndromes and genetic testing: Pathology and genetic testing.  Cancer.  80:636-648, 1997.

11. Markowitz S.  DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers. ASCO Education Book Spring.  20-26, 1997.

12.  Markowitz S.  Atherosclerosis, Just Another Cancer.  J. Clin. Invest.  100:2143-2145, 1997.

13.  Markowitz S.  DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.  1999 ASCO Education Book:  56-62, 1999.

14.  Sedwick WD, Markowitz S, Veigl M: Mismatch repair and drug responses in cancer. Drug Resistance Updates 2:295-306, 1999

15.  Markowitz S.  TFG-b receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesis. Biochim  Biophy Acta. 1470:M13-M20, 2000.

16.  Grady WM, Markowitz S.  Genomic instability and colorectal cancer.  In: Current Opinion in Gastroenterology.  16:62-67, 2000.

17.  Kim S-J, Im YH, Markowitz S, Bang YJ: Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis. Cytokine and Growth Factor Reviews 11:159-168, 2000.

18.  Markowitz S:  DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.  J. Clin Oncol.  18:75s-80s, 2000.

19.  Markowitz S, Dawson DM, Willis J, Willson JK: Focus on colon cancer. Cancer Cell 1:233-36,2002.

20.  Grady WM, Markowitz SD: Genetic and epigenetic alterations in colon cancer. Annu Rev Genomics Hum Genet  3:101-28, 2002.

21.  Markowitz S.  DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.  2003 ASCO Education Book:  4-11, 2003.

22.  Grady WM, Markowitz SD.  Hereditary colon cancer genes.  Methods Mol Biol 222:59-83, 2003.

23.  Markowitz SD. Aspirin and colon cancer--targeting prevention? N Engl J Med 356(21):2195-8, 2007.

24.  Markowitz S. Colorectal Neoplasia Goes with the Flow: Prostaglandin Transport and Termination. Cancer Prevention Research 1:77-79, 2008.

25.  Markowitz, SD, and Bertagnolli, MM. Molecular basis of colorectal cancer. N Engl J Med 361:2449-2460 2009.

Edited Books/Periodicals 

1.   Cancer Biology (Markowitz S, ed.) In:  Current Opinion in Oncology.  9:79-112, 1997.

1.      Cancer Biology (Markowitz S, ed.) In:  Current Opinion in Oncology.  10:67-91,  1998.

2.      Myeroff L, He H, Fink S, Markowitz S: Mutation detection in the TGF-beta receptors and Smad genes: RT-PCR and sequencing. In Methods Mol Biol (Howe P, ed). Totowa, NJ: Humana Press, pp 139-147, 2000.

3.      Myeroff L, Markowitz S: Detection of TGF-beta type II receptor hot-spot mutations: the BAT-RII assay. In Methods in Molecular Biology (Howe P, ed). Totowa, N.J.: Humana Press, pp 133-137, 2000.

4.      Mendlesohn J, Baird A, Fan Z, Markowitz S.  Growth factors and their receptors in epithelian malignancies.  In The Molecular Basis of Cancer (Mendlesohn J, Howley P, Israel M, Liotta L, editors) Philadelphia: W.B. Saunders;  pp 136-161, 2001.

5.    Grady W, Markowitz S: Colorectal cancer: genetic alterations. In Kelsen D, Daly J, Kern S, Levin B, Tepper J, editors. Gastrointestinal oncology principles and practice. Philadelphia: Lippincott, Williams and Wilkens, pp. 685-702, 2002.

6.      Grady W, Markowitz SD. TGF-ß Signaling Pathway and Tumor Suppression. In: Derynck R, Miyazano K, editors. The TGF-ß Family. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; pp. 889-938, 2008

7.      S.D. Markowitz, Case Western Reserve University, Cleveland, OH, USA; N.A. Berger, Case

Western Reserve University, Cleveland, OH, USA (Eds.).  Energy Balance and Gastrointestinal   Cancer.  Springer, 2012

Published Letters

1.      Markowitz, SD, Itzkowitz SH, Berber BM.  The effectiveness of colonoscopy in reducing mortality from colorectal cancer.  Ann Intern Med, Jun 2;150(11):816-7  2009