My laboratory has developed a particular interest in understanding the molecular mechanisms governing cerebrovascular homeostasis and the pathogenesis of stroke with an ultimate goal of finding novel therapeutic strategies to prevent and treat cerebrovascular disease. We have broad-based expertise in cellular/molecular biology, mouse genetic manipulation and phenotypic characterization, transcriptional regulation, and endothelial biology. Our prior work has demonstrated KLF2 as a critical regulator of endothelial function serving as a molecular switch mediating the favorable anti-inflammatory, anti-thrombotic, and anti-adhesive effects of blood flow on the vasculature. Our more recent in vivo studies of KLF2 deficiency demonstrate this factor to be necessary for maintenance of vascular permeability and inhibition of atherosclerosis. Exciting new observations from my laboratory implicate KLF2 as a central regulator of cerebrovascular function and homeostasis, findings that may have major implications for diseases such as ischemic stroke, multiple sclerosis, and Alzheimer’s disease.
Iris S. and Bert L. Wolstein Research Building
2103 Cornell Road
Office: WRB 4-542
Lab: WRB 4-304E