Department of Biomedical Engineering
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Dominique M. Durand

DOMINIQUE M. DURAND
EL Lindseth Professor of Biomedical Engineering
Departments of Biomedical Engineering, Neurosciences,
Physiology and Biophysics
Director, Neural Engineering Center
Editor in chief, Journal of Neural Engineering
Case Western Reserve University
Cleveland, OH, 44106
Wickenden 112
email: dxd6@case.edu
phone: 216 368 3974
fax: 216 368 4872
web: nec.cwru.edu


SHORT BIOGRAPHY

Dominique M. Durand is E.L. Linsedth Professor of Biomedical Engineering and Neurosciences and Director of the Neural Engineering Center at Case Western Reserve University in Cleveland, Ohio. He received an engineering degree from Ecole Nationale Superieure d'Electronique, Hydrolique, Informatique et Automatique de Toulouse, France in 1973. In 1974, he received a M.S. degree in Biomedical Engineering from Case Reserve University in Cleveland OH., worked several years at the Addiction Research Foundation of Toronto, Canada and in 1982 received a Ph.D. in Electrical Engineering from the University of Toronto in the Institute of Biomedical Engineering. He received an NSF Young Investigator Presidential Award as well as the Diekhoff and Wittke awards for graduate and undergraduate teaching and the Mortar board top-prof awards at Case Western Reserve University. He is an IEEE Fellow and also Fellow of the American Institute for Medical and Biomedical Engineering and Fellow of the Institute of Physics. He serves on five editorial boards of peer-reviewed scientific journals and he is the editor-in-chief and founding editor of the Journal of Neural Engineering. His research interests are in neural engineering and include computational neuroscience, neurophysiology and control of epilepsy, non-linear dynamics of neural systems, neural prostheses and applied magnetic and electrical field interactions with neural tissue. He has obtained funding for his research from the National Science Foundation, the National Institutes of Health and private foundations. He has published over 120 peer-reviewed articles and he has consulted for many biotechnology companies and foundations.


ARTICLES IN REFEREED JOURNALS

Citation indices: http://scholar.google.com/citations?user=KHm1GegAAAAJ

  All Since 2008
Citations 4804 2351
h-index 37 27
i10-index 97 69

 

RECENT PUBLICATIONS

Lee, S; Ryu, K; Waldo, A; Khrestian, C; Durand, DM; Sahadevan, J. An Algorithm to Measure Beat-to-Beat Cycle Lengths for Assessment of Atrial Electrogram Rate and Regularity during Atrial Fibrillation, Journal of Cardiovascular Electrophysiology, 24(2):199-206, 2013 PMID: 23140386

Lee, S; Sahadevan, J; Khrestian, C; Durand, D; Waldo, A, High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart - Restudying the Moe Hypothesis, Journal of Cardiovascular Electrophysiology, 24(3):328-35, 2013 PMID: 23210508

Toprani, S and Durand DM. Fiber Tract Stimulation Can Reduce Epileptiform Activity in an in-vitro Bilateral Hippocampal Slice Preparation, Experimental Neurology, 240:28-43, 2013, PMID: 23123405

Wodlinger B, S. Rashid and DM Durand "Block of Peripheral Pain Response by High Frequency Sinusoidal Stimulation", Neuromodulation: Technology at the Neural Interface, 16(4):312-7, 2013 PMID: 23294138

Feng Z, Zheng X, Yu. Y and DM Durand: Functional Disconnection of Axonal Fibers Generated by High Frequency Stimulation in the Hippocampal CA1 Region in-vivo. Brain Research, 1509:32-42, 2013. PMID: 23473842

Koubeissi MZ, Kahriman E, Syed TU, Miller J, Durand DM. Low Frequency electrical stimulation of a fiber tract in temporal lobe epilepsy. Ann Neurol. 2013.23915. In Print PMID: 23613463, 2013

Toprani, S and Durand DM. Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation, 591(Pt 22):5765-90, J. Physiology (London), 2013, PMID: 23981713

Gonzales, L., Ladas TP; Chiang CC: DM Durand, TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo. Experimental Neurology, 250:321-32, 2013, PMID: 24145133

Wang Y., Toprani, S., Tang Y., Vrabec T.; Dominique M Durand Mechanism of Highly Synchronized Bilateral Hippocampal Activity, Experimental Neurology, 251:101-11, 2014 PMID: 24262205

Zhang­­ M, Ladas TP, Qiu C., Shivacharan RS, Luis E. Gonzalez-Reyes, Dominique M. Durand Propagation of epileptiform activity can be independent of synaptic transmission, gap junctions or diffusion and is consistent with electrical field transmission, In Press, J. Neuroscience, 2014

Tang Y and Durand DM: Bayesian spatial filters for the extraction of source signals, a study in the peripheral nerve. In Press, IEEE Transactions on Neural Systems and Rehabilitation, 2014


RECENT INVITED PRESENTATIONS

  • Electrical Stimulation and Epilepsy, Grand Rounds Epilepsy, George Washington University, Washington, 2013
  • Seizure Control with Electrical Stimulation: from the bench to the clinic, University of Utah, 2013
  • Problems at the Peripheral Neural Interface, International Neuromodulation Society, Berlin, 2013
  • Interfacing with nervous system, A neural engineering approach, Neural Engineering Translation Summer conference, Nottingham, England, 2013
  • Reverse Stochastic Resonance, EMBS-Osaka, Japan, 2013
  • Neural Engineering Fundamentals, Kanto Gakuin Yokohama, Japan, 2013
  • Interfacing with the peripheral nervous system, EBMS summer school, Shanghai, China, 2013
  • Key note lecture, 6th International Neural Engineering Conference, SanDiego, 2013


RECENT PhD GRADUATES

Andrew Kibler, May 2011
Epileptiform propagation in the hippocampus and a recording array for in vitro analysis
Senior Research Engineer, Biotronik, Portland, OR

HyunJo Park, August 2011
Motion Control of Neuromuscular systems using a multiple contact nerve Electrode
Research Staff, Cleveland Clinic, Cleveland, OH

Yuang Tang, December 2011
Methods for the detection and suppression of medial temporal lobe epilepsy
Program Manager, Microsoft, Seattle, WA


CURRENT STUDENTS and STAFF MEMBERS

Research Associates

Luis Gonzales Reyes
Grant Mccallum
Chia-chu Chiang

Staff

Animal Technician: William Marcus

Graduate Students

Thomas Ladas (MSTP)
Sheela Toprani (MSTP)
Thomas Eggers
MingMing Zhang
Yazan Dweiri
Chen Qui
Nicholas Couturier (BS-MS))
David Dashevski (BS-MS)
Arvin Ananthakrishnan
Rajat Chivacharan

Undergraduate students

Trent Searfoss
Kia Sherman
Rushel Shah


RECENT TEACHING INVOLVEMENT

EBME 328: Student training on the use and documentation of laboratory equipment, bench processes or computational algorithm development/model analysis, that is relevant to biomedical science and engineering research.
EBME401: Biomedical Instrumentation and Signal analysis. Graduate students with various undergraduate backgrounds will learn the fundamental principles of biomedical measurements that integrate instrumentation and signal processing with problem-based hands-on experience.

EBME 421: Bioelectric Phenomena: Fundamental concepts of interaction between electrical and magnetic field with excitable tissue. Models of excitable cells and membranes. Neural and cardiac action potentials. Propagation of excitation. Principle of electrical stimulation of the nervous system. Bioelectric sources, volume conduction fields. Electrical recording from excitable tissue. Bi-domain models. Inverse problem in electrophysiology.


RESEARCH INTERESTS

Neural Engineering is a new discipline at the interface between engineering and neuroscience. Neural Engineering research in my laboratory combines computational neuroscience, engineering and electrophysiology to solve problems in the central and peripheral nervous systems. We are working at the cellular and molecular level in vitro. We also use in-vivo models have translated some of the projects into the clinic.

In the central nervous system, we are investigating the mechanisms of generation, propagation and synchronization of neuronal activity during epilepsy using in- vitro brain preparations, optogenetics, electrophysiology, in-vivo multiple electrode recording and computer models. The interaction between applied currents and neuronal tissue are studied to determine the feasibility of controlling seizures in patients with epilepsy.

In the peripheral nervous system, we are developing neural prosthetic systems. We have been developing the flat neural interface electrode (FINE) for stimulating and recording neuronal activity selectively. We rely heavily on computer simulation of both neurons and volume conductors in conjunction with the experiments for the quantitative analysis of neural systems and to design new electrodes for interfacing with the nervous system. We are working on the translating our design and systems into patients.


SOME RECENT RESEARCH PROJECTS

Macromachined high aspect ratio array for recording neural signals
This array allows two dimensional recording of 64 sites in vitro with high aspect ratio penetrating electrodes and has been used in transverse, longitudinal slices as well as intact hippocampus. (Kibler et al. J. Neuroscience methods, 2011)

 

Neuroprosthetic system for recording peripheral nerve signals in amputees.
We are developing a neuroprosthetic system based on the flat interface nerve electrode (FINE) to selectively record from and stimulate peripheral nerves. The signals are acquired using a multiple channels cuff electrode, processed using detection algorithm to reveal the location of the source within the various fascicles and used to control a prosthetic arm. Stimulation can also be applied to restore sensation in amputees. (Wodlinger and Durand, J. Neural Engineering, 2012)

 

Mechanism of seizure suppression by low frequency stimulation (LFS).
We have developed a new hippocampal bilateral preparation to show that LFS of fiber tracks can block seizure activity. These experiments have been validated in-vivo in animal models of epilepsy.(Toprani et Durand, J. Neurophysiology 2013)

 

Propagation of neural activity in the brain
Our recent experiments in the hippocampus reveal a novel form of neural activity propagation that is independent of synaptic transmission or gap junctions. The signals is a wave carried by extracellular electrical fields propagating at a speed of about 0 .1m/s. (Zhang et al, J, Neuroscience 2013)

 

Seizure suppression in patients.
We have translated our successful seizure suppression method tested in-vitro and in vivo in the clinic. In patients with mesial temporal lobe epilepsy, a stimulation electrode is placed into the dorsal hippocampal commissure and 5 Hz stimulation is applied with 90% seizure reduction. (Koubeissi et al, Annals of Neurology, 2013)

 

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