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Research
Cell Transport: Cell transport is important in several physiological and pathological processes such as inflammation, embryogenesis, cancer metastasis and wound healing. Several mechanisms of cell transport have been identified: passive transport through random diffusion and active transport via convection and mechanisms such as chemotaxis, chemokinesis, and haptotaxis. The main goal of this research is to understand various mechanisms of cell transport and to modulate the growth of cell monolayers.
Selected PublicationsV. Janakiraman, S. Sastry, J. Kadambi, and H. Baskaran. “Experimental Characterization and Computational Modeling of Hydrodynamics in Bifurcating Microchannel Networks”, Biomedical Microdevices, (In Press) V. Janakiraman, B. Kienitz, and H. Baskaran. “Lithography Techniques for Topographical Micropatterning of Collagen-Glycosaminoglycan Membranes for Tissue Engineering Applications” Journal of Medical Devices, 1(3), 233-237, September, 2007. S. Shaikh, A. Birdi, S. Qutubuddin, E. Lakatosh, and H. Baskaran. “Controlled Release in Transdermal Pressure Sensitive Adhesives using Organosilicate Nanocomposites” Annals of Biomedical Engineering, September 1, 2007 (Epub) B. Bustard, and H. Baskaran. “Migratory Characteristics of Microfabricated Cell Islands of Breast Cancer Cell Lines of Varying Metastatic Potentials”, Biomedical Microdevices, (Accepted for publication) V. Janakiraman, K. Mathur, and H. Baskaran. “Optimal Planar Capillary Network Designs for Tissue Engineered Constructs with Built-in Microvasculature”, 35(3), 337-347 March 2007 Annals of Biomedical Engineering. L. S. Solchaga, E. Tognana, K. Penick, H. Baskaran, A. Caplan, V. Goldberg, and J. F. Welter. “A Rapid Vacuum-Seeding Technique for the Assembly of Large Tissue-Engineered Cell/Scaffold Composites”, 12, 1851-63, Tissue Engineering, 2006. H. Baskaran*, Noo Li Jeon*, S. W. Dertinger, L. Van De Water, G. M. Whitesides, and M. Toner. “Neutrophil Chemotaxis in Linear and Complex Gradients of Il-8 Formed in a Microfabricated Device”, 20, 826-830, Nature Biotechnology, 2002. H. Baskaran*, P. Roy*, A. W. Tilles, M. L. Yarmush, and M. Toner. “Analysis of Oxygen Transport to Hepatocytes in a Flat-Plate Microchannel Bioreactor”, 29, 947-955, Annals of Biomedical Engineering, 2001. A. W. Tilles, H. Baskaran, P. Roy, M. L. Yarmush, and M. Toner. “Effects of Oxygenation and Flow on the Viability and Function of Rat Hepatocytes Co-Cultured in a Microchannel Flat-Plate Bioreactor”, Biotechnology and Bioengineering, 73, 379-89, 2001. |
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Microvascular Tissue Engineering: Tissue engineering has the potential to revolutionize healthcare. A significant challenge in tissue engineering is to overcome substrate mass transfer limitations, which if ignored can result in a product that will not function adequately. The main goal of this research is to design and build microvascular flow analogs that can be used to overcome nutrient limitations in tissue-engineered products.