Department of Biomedical Engineering
Wickenden Building
Phone 368-4094; Fax 368-4969
Gerald M. Saidel
Biomedical engineering (BME) uniquely integrates engineering, physical and mathmatical sciences, technology, biomedical sciences and clinical applications. Biomedical engineers contribute to better health care (a) by developing devices and procedures for diagnosis and therapy, (b) by research that quantifies biomedical systems and processes, and (c) by effective management of medical technology. These aspects of biomedical engneering are included in the CWRU educational programs for the B.S., M.S., Ph.D., and M.D./Ph.D. in Biomedical Engineering and the M.S. in Clinical Engineering (which is also a specialty sequence of the B.S. in Biomedical Engineering).
A central educational objective of our programs is to ensure that students develop the depth and breadth in engineering necessary to solve biomedical problems. Training in biomedical engineering leads to employment in industry, hospitals, research centers, and universities. Biomedical engineering can also provide the basis for careers in medicine and other professions.
The Department of Biomedical Engineering was established in 1967 as one of the pioneer programs in the world. It has been a leader in the field and ranks among the largest and most prestigious. As an independent department in both the Case School of Engineering and the School of Medicine, BME at CWRU offers students exceptional opportunities to interact with faculty. Major departmental research activities include applied neural control/rehabilitation engineering (neural and neuromuscular prostheses); biomaterials (orthopedic implants, biopolymers, & interfaces); cardio-electric phenomena (modeling & potential imaging); biomedical sensors (chemical, optical & mechanical); biomedical imaging processing (X-ray, MRI, ultrasound & PET); brain electromagnetic phenomena (modeling & cellular measurements). Faculty research laboratories are located in the Case School of Engineering, School of Medicine, University Hospitals, Cleveland Clinic Foundation, and VA Medical Center (which are all within a short walk) as well as in MetroHealth Medical Center. These laboratories provide extensive educational resources for undergraduate and graduate students.
Gerald M. Saidel, Ph.D. (Johns Hopkins University)
Professor and Chairman
Transport and metabolic analysis in tissues
J. Ricardo Alcala, Ph.D. (University of Illinois)
Assistant Professor
Fiberoptic biosensors; measurement of blood components; protein biophysics
Stanley A. Brown, D. Eng. (Dartmouth)
Associate Professor
Biomaterials; corrosion and failure of metallic implants
Patrick E. Crago, Ph.D. (Case Western Reserve University)
Professor
Control of neuroprotheses for motor function; neuromuscular control systems
Dominique Durand, Ph.D. (University of Toronto, Canada)
Associate Professor
Electrical properties of brain cells; neural prostheses; biomagnetism
Janie M. Fouke, Ph.D. (University of North Carolina, Chapel Hill)
Associate Professor
Respiratory mechanics; biomedical transducers and optical sensors
Miklos Gratzl, Ph.D. (Technical University of Budapest, Hungary)
Assistant Professor
Electrochemical biosensors; diffusional microtitration of cells
J. Lawrence Katz, Ph.D. (Polytechnic Institute of Brooklyn)
Professor
Structure-property relationships in bone; scanning acoustic microscopy
Roger Marchant, Ph.D. (Case Western Reserve University)
Associate Professor
Biopolymers; biomolecular materials; implant surface coatings
Katharine Merritt, Ph.D. (University of Michigan)
Associate Professor
Infection at implant sites; immune responses to implant materials
J. Thomas Mortimer, Ph.D. (Case Western Reserve University)
Professor; Director, Applied Neural Control Laboratory
Neural prostheses; electrical activation of neural tissue; membrane properties and electrodes
P. Hunter Peckham, Ph.D. (Case Western Reserve University)
Professor; Director, Rehabilitation Engineering Center
Motor function restoration with neural prostheses, control of orthotic/prosthetic systems
Yoram Rudy, Ph.D. (Case Western Reserve University)
Professor; Director, Cardiac Electrophysiology Simulation Laboratory
Modeling of cellular activity and cardiac excitiation; electrocardiographic imaging
Cecil W. Thomas, Ph.D. (University of Texas, Austin)
Associate Professor
Biomedical image and signal processing; human perception; electrical
potential mapping
W. Sanford Topham, Ph.D. (University of Utah)
Associate Professor and Associate Dean
Medical instrumentation; clinical engineering
David L. Wilson, Ph.D. (Rice University)
Assistant Professor
Medical image processing; X-ray imaging; intravascular ultrasound
James M. Anderson, Ph.D.(Oregon State University), M.D. (Case Western Reserve University)
Professor of Pathology
Biocompatibility of implants
Ronald L. Cechner, Ph.D. (Case Western Reserve University)
Associate Professor of Pathology
Microscopic imaging
Howard J. Chizeck, Sc.D. (Massachusetts Institute of Technology)
Professor of Systems Engineering
Physiological control; control system design
Dwight T. Davy, Ph.D. (University of Iowa
Professor of Mechanical Engineering
Biomechanics; mechanical properties of bone
Louis F. Dell'Osso, Ph.D. (University of Wyoming)
Professor of Neurology
Neurophysiological and ocular motor control systems
Pedro J. Diaz, Ph.D. (Case Western Reserve University)
Assistant Professor of Radiologic Physics
Magnetic resonance imaging; image processing
Jeffrey L. Duerk, Ph.D. (Case Western Reserve University)
Assistant Professor of Radiologic Physics
Magnetic resonance imaging; flow visualization
E. Mark Haacke, Ph.D. (University of Toronto, Canada)
Professor of Radiologic Physics
Magnetic resonance imaging; cardiovascular imaging
Michael W. Keith, M.D. (Ohio State University)
Associate Professor of Orthopaedic Surgery
Restoration of motor function in hands
R. John Leigh, M.D. (University of Newcastle-Upon-Tyne, U.K.)
Professor of Neurology
Normal and abnormal motor control of the eye
Matthew N. Levy, M.D. (Case Western Reserve University)
Professor of Physiology
Cardiac excitation; contractility; cardiac control
Jerome Liebman, M.D. (Harvard University)
Professor of Pediatrics
Electrocardiography; surface potential mapping
E. Byron Marsolais, M.D., Ph.D. (University of Iowa)
Associate Professor of Orthopaedic Surgery
Prostheses for leg movement and walking
Paul J. Martin, Ph.D. (Case Western Reserve University)
Professor of Physiology
Cardiovascular control systems; neural control of the heart
Floro D. Miraldi, Sc.D. (Massachusetts Institute of Technology), M.D. (Case
Western Reserve University)
Professor of Biomedical Engineering and Associate Professor of Radiology
Positron emission tomography; radiation diagnostics
Dennis A. Nelson, Ph.D. (Case Western Reserve University)
Associate Professor of Radiology
Positron emission tomography; diagnostic imaging
Michael R. Neuman, Ph.D., M.D. (Case Western Reserve University)
Associate Professor of Reproductive Biology
Biomedical transducers for implants and patient monitoring
David S. Rosenbaum, M.D. (University of Illinois, Chicago)
Assistant Professor of Medicine
Optical imaging in cardiac electrophysiology.
Michael L. Smith, Ph.D. (North Texas State University)
Assistant Professor of Medicine
Autonomic control of cardiovascular function
Clayton L. Van Doren, Ph.D. (Syracuse University)
Assistant Professor of Orthopaedics
Kinesthetic and tactile function; sensory feedback for prostheses
Albert L. Waldo, M.D. (State University of New York)
Professor of Medicine
Cardiac electrophysiology and cardiac excitation mapping
J. Michael Watkins-Pitchford, M.D. (St. Thomas' Hospital Medical School, England)
Assistant Professor of Anesthesiology
Ion-selective biosensors; surgical patient monitoring
Thomas W. Bauer, M.D., Ph.D. (University of Nebraska)
Adjunct Assistant Professor of Biomedical Engineering
(Pathology, Cleveland Clinic Foundation)
Orthopaedic biomaterials; surface coating of implants
Guy M. Chisolm III, Ph.D. (University of Virginia)
Adjunct Associate Professor of Biomedical Engineering
(Cell Biology, Cleveland Clinic Foundation)
Lipoprotein-cell interactions.
Thomas F. Collura, Ph.D. (Case Western Reserve University)
Adjunct Assistant Professor of Biomedical Engineering
(Neurophysiology, Cleveland Clinic Foundation)
Monitoring and analysis of brain signals; epilepsy
Mark. D. Grabiner, Ph.D. (University of Illinois)
Adjunct Assistant Professor of Biomedical Engineering
(Biomedical Engineering, Cleveland Clinic Foundation)
Neuromotor control of human performance
Hiroaki Harasaki, Ph.D., M.D. (Kyushu University, Japan)
Adjunct Associate Professor of Biomedical Engineering
(Biomedical Engineering, Cleveland Clinic Foundation)
Artificial heart; blood-surface interactions
Vincent J. Hetherington, D.P.M. (Pennsylvania College of Podiatric Medicine)
Adjunct Assistant Professor of Biomedical Engineering
(Surgery, Ohio College of Podiatric Medicine)
Biomaterials and biomechanics of foot prostheses
Kandice Kottke-Marchant, Ph.D., M.D. (Case Western Reserve University)
Adjunct Assistant Professor of Biomedical Engineering
(Hematology, Cleveland Clinic Foundation)
Interaction of blood and materials
Otto Prohaska, D. Tech. Sci. (Technical University of Vienna, Austria)
Adjunct Associate Professor of Biomedical Engineering
Micro-electronic sensors and electrodes
Mark S. Rzeszotarski, Ph.D. (Case Western Reserve University)
Adjunct Assistant Professor of Biomedical Engineering
(Radiology, Mt. Sinai Medical Center)
Radiology imaging; MRI, SPECT, ultrasound
Jean A. Tkach, Ph.D. (Case Western Reserve University)
Adjunct Assistant Professor of Biomedical Engineering
(Radiology, Cleveland Clinic Foundation)
Magnetic resonance angiography; cardiac MRI
Maciej Zborowski, Ph.D. (Polish Academy of Science)
Adjunct Assistant Professor of Biomedical Engineering
(Biomedical Engineering, Cleveland Clinic Foundation)
Membrane separation of blood proteins
The CWRU undergraduate program leading to the Bachelor of Science degree with a major in biomedical engineering was establishedin 1972. In this program, students obtain depth in some engineering specialty as well as breadth in engineering applied to biomedical problems. Because our department faculty is large and the Case School of Engineering has many areas of strength, students can choose from a variety of specialty areas. The B.S. program in Biomedical Engineering is fully accredited by the Accreditation Board of Engineering and Technology.
B.S. graduates are prepared for careers in industry and medical centers as well as for graduate study in biomedical engineering or other disciplines. Students with engineering ability and an interest in medicine may consider the undergraduate biomedical engineering program as a challenging alternative to conventional premedical programs.
Undergraduates with a strong academic record may apply in their junior year for admission to the integrated B.S./M.S. program, which enables the student to obtain the M.S. in a shorter time than usual.
The undergraduate program has four major components: (1) Case Core, (2) Engineering Core, (3) Biomedical Engineering Core, and (4) Engineering Specialty Electives. The Case and Engineering cores provide a broad background in mathematics, sciences, and engineering. A typical program of study is shown in the table. The Biomedical Engineering Core gives students an opportunity to apply engineering to biomedical problems. Hands-on experience in BME is developed through the undergraduate laboratory and project courses. In addition, by choosing a specialty elective sequence, the student can learn in depth about a specific engineering area. This integrated program is designed to ensure that BME graduates are competent engineers. Students may select open electives for educational breadth or depth or to meet entrance requirements of medical school or other professional career choices. BME faculty serve as student advisors to guide students in choosing the program of study most appropriate for individual needs and interests.
Common engineering specialties are biomaterials (metals), biomaterials (polymers), biomechanics (orthotics & prosthetics), biomedical computing (data processing & imaging), clinical engineering, biomedical instrumentation (devices & sensors), and biomedical systems (analysis & control). Clinical engineering is a specialty that emphasizes the application of technology in a hospital environment. Courses for these specialties are presented below. Complete descriptions and suggested schedules for approved specialties are available from the department. These specialties provide the student with a solid background in a well-defined area of biomedical engineering. To meet specific educational needs, students may choose alternatives from among the suggested electives or design unique specialties subject to departmental guidelines and faculty approval.
Bachelor of Science in Engineering Degree
FRESHMAN
FALL SEMESTER
EBME 105, Introduction to Biomedical Engineering (b) (3-0-3)
CHEM 105, Principles of Chemistry I (3-0-3)
MATH 121, Calculus for Science and Engineering I (4-0-4)
CMPS 131, Elementary Computer Programming (2-2-3)
ENGL 150, Expository Writing (3-0-3)
PHED 101, Physical Education (0-3-0)
Total (15-5-16)
SPRING SEMESTER
CHEM 106, Principles of Chemistry II (3-0-3)
CHEM 113, Principles of Chemistry Lab (1-3-2)
MATH 122, Calculus for Science and Engineering II (4-0-4)
PHYS 120, General Physics I (4-0-4)
Humanities/Social Sciences (3-0-3)
PHED 102, Physical Education (0-3-0)
Total (15-6-16)
SOPHOMORE
FALL SEMESTER
EBME 201, Physiology - Biophysics I (3-0-3)
MATH 223, Calculus for Science and Engineering III (3-0-3)
PHYS 219, General Physics II (4-0-4)
EBME 306, Introduction to Biomaterials (3-0-3)
Engineering Specialty/Core (c) (3-0-3)
Total (16-0-16)
SPRING SEMESTER
EBME 202, Physiology - Biophysics II (3-0-3)
MATH 224, Elementary Differential Equations (3-0-3)
PHYS 220, General Physics III (3-0-3)
Engineering Specialty/Core (c) (3-0-3)
Humanities/Social Sciences (3-0-3)
Total (15-0-15)
JUNIOR
FALL SEMESTER
EBME 313, Biomedical Engineering Lab I (1-3-1)
EBME 315, Biomedical Engineering Lab III (1-3-1)
ESYS 212, Systems and Signals (3-0-3)
ENGL 398, Professional Communication (2-0-2)
Engineering Specialty/Core (c) (6-0-6)
Humanities/Social Sciences (3-0-3)
Total (16-6-16)
SPRING SEMESTER
EBME 314, Biomedical Engineering Lab II (1-3-1)
EBME 316, Biomedical Engineering Lab IV (1-3-1)
EBME 310, Principles of Biomedical Insrumentation (3-0-3)
EBME 312, Processing of Signals and Images (d) (3-0-3) or (1-0-1)
Engineering Specialty/Core (c) (6-0-6) or (9-0-9)
Humanities/Social Sciences (3-0-3)
Max (18-6-18)
SENIOR
FALL SEMESTER
EBME 398, Senior Project (1-6-3)
STAT 385, Statistical Methods (3-0-3)
Engineering Specialty/Core (c) (6-0-6)
Humanities/Social Sciences (6-0-6)
Total (16-6-18)
SPRING SEMESTER
EBME 309, Modeling of Biomedical Systems (3-0-3)
Engineering Specialty/Core (c) (6-0-6) or (9-0-9)
Open elective (3-0-3) or (6-0-6)
Humanities/Social Sciences (3-0-3)
Max (18-0-18)
a This is a typical program. Specific programs must be planned with a faculty adviser in the Department of Biomedical Engineering.
b Optional and limited to freshmen.
c One or more courses are chosen depending on the BME Specialty Sequence. Guidelines and advice are provided by the BME department and faculty.
d The number of credits depends on the BME Specialty Seqence.
Common BME Specialty Sequences
Biomaterials (metals & polymers)
- All-EMSE 201, EBME 303, EBME 405
- Metals-CHEM 301, EMSE 202, EMSE 303, EMSE 411
- Polymers-EMAC 171/172, EMAC 376, CHEM 223, EBME 406
Biomechanics (orthotics & prosthetics)
- ECIV 110, EMAE 181, EMAE 271, ECIV 210
- EMAE 360, EMAE 372, EMAE 415
Biomedical Computing (information & imaging processing)
- EEAP 282, ECMP 333, ECMP 337,
- ECMP 338 or CMPS 341 or CMPS 391
- ECMP 398 or ECMP 431
- EBME 410 or EBME 414
Biomedical Instrumentation (transducers & sensors)
- EEAP 243/244, ECMP 280, EEAP 282,
- EEAP 381, EEAP 309, EBME 418
Biomedical Systems (analysis & control)
- ESYS 313, ESYS 304/305, ESYS 322,
- ESYS 346/321, EBME 414
Clinical Engineering
- EEAP 243/244, ECMP 280, EEAP 309,
- EBME 332, ORBH 250, EBME 341, EBME 418
- EBME 414 or EBME 410
A minor in Biomedical Engineering is offered to students who have taken the Case Core requirements. The minor consists of 15 credit hours based on two required courses, EMBE 201/EBME202 and three electives chosen from among EBME 303, EMBE 306, EMBE 309, EMBE 310, and EBME 312.
The M.S. program in Biomedical Engineering provides breadth in biomedical engineering and biomedical sciences with depth in an engineering specialty. In addition, students are expected to develop the ability to work independently on a biomedical research or design project. A graduate with an M.S. in Clinical Engineering is prepared to take technical and administrative responsibility for medical devices, computer systems, and related facilties in hospitals.
For those students with primary interest in research, the Ph.D. in Biomedical Engineering provides additional depth and breadth in engineering and the biomedical sciences. Under faculty guidance, students are expected to undertake original research motivated by a biomedical problem. Research possibilities include the development of new theory, devices, or methods for diagnostic or therapeutic applications as well as for measurement and evaluation of basic biological mechanisms.
A small number of students with outstanding qualifications are admitted to the Ph.D./M.D. program, which requires approximately seven years of intensive work after a B.S.
Applied Neural Control/Rehabilitation Engineering
Implanted neural prostheses for motor control of hand, finger, leg, and foot movements. Electrical and magnetic stimulation of the nervous system. Neural control of spine, bladder, and diaphragm. Prostheses for brain lesions such as epilepsy.
Biomaterials (Metals and Polymers)
Metallic, polymeric, and composite materials for implantation in the human body. Polymer surface coatings on implants and sensors. Structure-property relations in bone. Corrosion and failure of implants. Tissue reactions to implants.
Biomedical Image Processing and Analysis
X-ray imaging in bone. Cardiac electrical potential mapping. Magnetic resonance imaging with applications to the cardiovascular system. Intravascular ultrasound imaging. Human visual perception. Positron emission tomography of the brain.
Biomedical Sensors
Electrochemical and optical microsensors based on solid-state, thin-film, and fiber-optic technologies. Measurement of ions, enzymes, neurotransmitters, etc. in normal and pathological cells and tissues. Acute and chronic clinical monitoring of body fluids.
Cardio-Electric Phenomena
Cardiac electrophysiology. Models of cellular activity and cardiac excitation. Mechanisms of cardiac arrhythmias. Optical imaging of electrical propagation in the heart. Electrical potential modeling and mapping of the heart for diagnosis and treatment.
The central offices of the Department of Biomedical Engineering located in the Wickenden Building, which contains laboratories for Biomedical Image Processing, Electrochemical Biosensors, Fiber-optic Biosensors, Ion-Selective Biosensors, Characterization and Testing of Orthopaedic Implants, Biopolymers & Biomaterials Interfaces, Cardiac Electrophysiology Simulation, Optical Electrocardiographic Imaging, and Respiratory Mechanics. The department has an educational computer laboratory with a variety of high-performance computers with network connections.
Primary BME faculty are also directors of laboratories in other locations. The Applied Neural Control Laboratory is a major facility for basic research and animal experimentation in the development of neural prostheses. The Functional Electrical Stimulation Laboratory produces implantable prostheses for control of movement. The Rehabilation Engineering Laboratory provides clinical testing of neural processes.
The department faculty and students have access to the facilities and major laboratories of the Case School of Engineering and of the School of Medicine. Faculty have numerous collaborations at University Hospitals, MetroHealth Medical Center, Mt. Sinai Medical Center, VA Medical Center, and the Cleveland Clinic Foundation. These provide extensive research resources in a clinical environment for both undergraduate and graduate students.
Biomedical Engineering (EBME)
EBME 105. Introduction to Biomedical Engineering (3).
Biomedical engineering fields of activity. Research, development, and design for biomedical problems, diagnosis of disease, and therapeutic applications.
EBME 201. Physiology-Biophysics I (3).
Cell physiology. Metabolic processes. Electrophysiology of nerve and muscle. Motor system. Central nervous system. Sensory systems. Prerequisite: Consent of instructor.
EBME 202. Physiology-Biophysics II (3).
Physiology of the circulatory, renal, endocrine, respiratory, and other organ systems. Prerequisite: EBME 201 or consent of instructor.
EBME 303 Structure of Biologic Materials (3).
Structure of proteins, nucleic acids, connective tissue and bone from molecular to microscopic levels. Principles and applications of instruments for imaging, identification, and measurement of biological materials. Prerequisite: EBME 201 or consent of instructor.
EBME 306. Introduction to Biomedical Materials (3).
General principles of materials science; biological applications. Requirements and evaluation of materials for compatibility with the body tissues. Specific applications of biomedical materials. Prerequisite: EBME 201 or consent of instructor.
EBME 309. Modeling of Biomedical Systems (3).
Neuromuscular control of skeletal movement and eye movement. Chemical control of respiration. Transport and mechanics of tissues applied to blood dialysis and ventilatory mechanics. Electrophysiological models with application to the heart. Prerequisites: EBME 201, 202, ESYS 212.
EBME 310. Principles of Biomedical Instrumentation. (3).
Electrical, mechanical, and chemical principles for biomedical measurements. Modular blocks and system integration. Sensors for electrical potentials, measurement of pressure, flow, and other physiological variables. Patient safety. Ethics. Prerequisites: EEAP 240, ESYS 212, EBME 312 (1).
EBME 312 Processing of Signals and Images. (1 or 3 credits).
Digital signal processing. Complex and random signals. Fourier series and transforms. Linear filters. Image acquisition techniques. Image filtering and enhancement. Morphological processing. Feature extraction. Simulations and biomedical applications. Prerequisite: ESYS 212
EBME 313. Biomedical Engineering Laboratory I (1).
Experiments for measurement, replacement, or control of biomedical systems. Noninvasive measurements and laboratory computing. Mechanical properties of bone. Control of the nervous orthotic and prosthetic systems. Mass transfer in the artificial kidney. Pulmonary function testing. Cardiac pacing. Ventricular assist devices. Prerequisite EBME 201, 202. Corequisite: ENGL 398.
EBME 314. Biomedical Engineering Laboratory II (1).
Continuation of EBME 313. Prerequisite: EBME 201, 202. Corequisite: EBME 310.
EBME 315. Biomedical Engineering Laboratory III (1).
Similar to EBME 313. Prerequisite EBME 201, 202.
EBME 316. Biomedical Engineering Laboratory IV (1).
Similar to EBME 314. Prerequisite: EBME 201, 202. Corequisite: EBME 310.
EBME 332. Hospital Management for Clinical Engineers (l).
Basic management processes and their application in a hospital setting. Role of the clinical engineer as a manager within a hospital organization. Prerequisite: Consent of instructor.
EBME 341. Clinical Engineering Laboratory (2).
Use of medical equipment and modern technology in the hospital environment. Corequisite: EBME 310.
EBME 394. Senior Projects for Clinical Engineering (3).
Projects coordinated with a hospital internship. Prerequisite: Consent of instructor.
EBME 396. Special Topics in Undergraduate Biomedical Engineering I (credit as arranged).
Prerequisite: Consent of instructor.
EBME 397. Special Topics in Undergraduate Biomedical Engineering II (credit as arranged).
Prerequisite: Consent of instructor.
EBME 398. Senior Projects Laboratory I (3).
EBME 399. Senior Projects Laboratory II (3).
EBME 403. Biomedical Instrumentation (3).
Analysis and design of transducers and signal processors. Measurements of physical, chemical, biological, and physiological variables. Special-purpose medical instruments. System design, storage and display. Grounding, noise, and electrical safety. Ethics. Prerequisites: EBME 310 or consent of instructor.
EBME 405. Materials for Prosthetic and Orthotic Use (3).
Fundamental concepts of metallic and ceramic materials. Wear, corrosion, and failure of implanted metals. Properties of hard tissues and joints. Characterization of biomaterials. Biological process of inflammation, wound healing, implant incapsulation, and reactions. Biocompatibility of materials. Orthopaedic and dental applications. Prerequisite: Consent of instructor.
EBME 406. Polymers in Medicine (3).
Plastic implants in the body. Chemical and physical characteristics of biomedical polymers. Implant requirements, host-implants reactions. Physiological and biomechanical basis for soft-tissue implants. Design of modified biometerials. Prerequisite: Consent of instructor.
EBME 407. Applied Neural Control (3).
Fundamental concepts related to electrical stimulation of the nervous system. Electrical stimulation for functional control of the nervous system. Applications to neuromuscular, sensory, and other physiological systems. Prerequisites: EBME 451 and consent of instructor.
EBME 409. Systems and Signals in Biomedical Engineering (4).
Analysis of continuous and discrete systems and signals. Transform methods. System modeling and control. Computer simulation. Application to biomedical problems. Prerequisite: MATH 224 or equivalent.
EBME 410. Medical Imaging Fundamentals (3).
Physical principles of medical imaging. Imaging devices for x-ray, ultrasound, magnetic resonance, etc. Image quality descriptions. Patient risk. Prerequisite: EMBE 409 or consentof instructor.
EBME 411. Artificial Organs (3).
Engineering for replacement of kidney, lung, heart, and other organ functions. Chemical, electrical, mechanical, materials, pathological and surgical aspects. Prerequisites: EBME 201, 202 or consent of instructor.
EBME 412. Digital Processing of Biomedical Signals (3).
Application of digital processing techniques to biomedical signals. Spectra and digital filters. Processing evoked responses. Electrocardiograms, electroencephalograms, and other applications. Prerequisite: EBME 409 or consent of instructor.
EBME 414. Laboratory Computing in Biomedical Engineering (3).
Hardware and software aspects of computer systems for biomedical laboratory application. Design of systems for specified analog and digital interfacing. Signal conditioning and sample requirements. Computer control of laboratory instruments and data acquisition. Prerequisites: consent of instructor.
EBME 418. Electronics for Biomedical Engineering (3).
Analog design for biomedical electronics. Low noise, precision amplification, shielding, grounding, telemetry, interfacing, and electrical safety.. Applications include biomagnetic field measurements and intracellular recording. Prerequisite: EEAP 243,244 or consent of instructor.
EMBE 425. Cellular Reactions to Biomaterials (3).
Microbiology, immunology, and histology pertaining to interaction of host tissue and biomaterials. Sterilization and aseptic techniques. Pathogenic mechanisms of bacteria, viruses, and rickettsia. Inflammatory responses, humoral immunity, and cell-mediated immunity. Prerequisite: Consent of instructor.
EMBE 427. Rehabilitation Engineering (3).
Application of techniques to compensate for physical disabilities. Etiology of handicapping conditions. Restoration of movement, control, and communication for physically handicapped. Control interfaces. Prerequisite: Consent of instructor.
EBME 432. Hospital Management for Clinical Engineers (1).
Basic management processes and their application in a hospital setting. Role of the clinical engineer as a manager within a hospital organization. Prerequisite: Consent of instructor.
EBME 441. Clinical Engineering Laboratory (2).
Clinical diagnostic techniques and equipment. Clinical chemistry instrumentation. Patient monitoring and support during operations and in critical care. X-ray and radioactive tracer methods. Trouble-shooting and maintenance. Electrical safety. Ethics. Prerequisite: Consent of instructor.
EBME 451. Physiological Processes I (3).
Cell biology, metabolism and immunology. Nerve and muscle function. Motor systems and feedback control. Autonomic system mechanisms. Higher centers for regulation. Prerequisite Graduate standing.
EBME 452. Physiological Processes II (3).
Cardiovascular system. Respiratory, renal, and regulatory systems. Gastrointestinal system and metabolism. Prerequisite: EBME 451 or consent of instructor.
EBME 454. Orthotic and Prosthetic Systems. (3).
Design and operation of orthotic and prosthetic systems. Control interface to the human user. Motor and sensory augmentation for amputee, spinal cord injured, and stroke patients. Mechanical design of passive and powered limb replacements for upper and lower extremities. Restoration of movement by functional neuromuscular stimulation. Prerequisite: EBME 451 and consent of instructor.
EBME 501. Bioelectric Phenomena (3).
Models of excitable membranes. Hodgkin-Huxley equations. Electrotonous. Models of cardiac action potentials. Propagation of excitation. Electrical fields generated by excitable cells. Analysis of bioelectric sources and volume conductor fields. Bioelectric inverse problems. Prerequisite: EBME 451 or consent of instructor.
EBME 502. Cardiac Excitation. Rhythm, and Control (3).
Cardiac excitation at the cellular and sub-cellular levels. Electrical communication between cells. Propagation of the cardiac electrical potential. Cardiac arrhythmias. Neural control of the heart. Vagal nerve stimulation and sympathetic-vagal interaction. Neurotransmitters and neuropeptides. Prerequisite: Consent of instructor.
EBME 504. Transport Processes of Biomedical Systems (3).
Mass and heat transport processes. Metabolic processes. Spatially lumped and distributed models of organs, tissues and cells. Numerical methods for computer simulation. Applications to respiratory, cardiovascular, renal, gastrointestinal, and other systems. Prerequisite: Consent of instructor.
EMBE 510. Diagnostic Imaging (3).
Quantitative use of imaging modalities in patient care and clinical research. Utility and limitations of different modalities, e.g., CAT, MRI, PET. Prerequisites: EMBE 410 and consent of instructors.
EBME 512. Biomedical Image Processing and Analysis (3).
Principles and applications of image processing and pattern recognition by computer. Applications to x-ray images, magetic resonance angiography and cardiac images, cell counting and identification, and ultrasound scans of soft tissue. Prerequisite: EBME 412 or consent of instructor.
EBME 515. Material Properties of Hard Tissue (3).
Normal histological and mechanical state of bone and tooth. Models for relating structure and properties. Criteria for selection of hard-tissue replacement materials and bonding. Prerequisites: EBME 405 and consent of instructor.
EBME 519. Parameter Estimation for Biomedical Systems (3).
Linear and nonlinear parameter estimation of static and dynamic models. Identifiability and parameter sensitivity analysis. Statistical and optimization methods. Design of optimal experiments. Applications to metabolic, respiratory, and cardiovascular systems. Prerequisite: Consent of instructor.
EBME 523. Biosensors (3).
Fundamental electrical, electrochemical, and optical measurement techniques. Sensitive and selective biological membranes based on ion, enzyme, and immuno-reactions. Sensor stability and response time. Prerequisite: EBME 403 and consent of instructor.
EBME 540. In-Service Training for Clinical Engineers (3).
Training in hospitals for students in clinical engineering program.
EBME 541. Clinical Engineering Seminar I (1).
Problems analysis in clinical engineering.
EBME 542. Clinical Engineering Seminar II (1).
Similar to EBME 541.
EBME 550. Clinical Engineering Project (3-5).
Engineering project during the hospital internship or special project in clinical engineering.
EBME 601. Research Projects in Biomedical Engineering (credit as arranged).
Prerequisite: Consent of instructor..
EBME 602. Special Topics in Biomedical Engineering (Credit as arranged).
Prerequisite: Consent of instructor.
EBME 651. Thesis (M.S.) (credit as arranged).
EBME 701. Dissertation (Ph.D.) (credit as arranged).
Ph.D. candidates only.
CWRU Provost's Office --
About this server
-- Copyright 1996 CWRU
-- Unauthorized use prohibited
|