l Chemistry (3)
Topics in physical chemistry, intended for entering graduate students, giving background tools appropriate for graduate research in areas of chemistry other than physical chemistry. Illustrations from the contemporary chemical research literature will be emphasized. Thermodynamics and statistical mechanics, quantum chemistry and computation, spectroscopy, and chemical kinetics and dynamics. Recommended preparation: One year of undergraduate physical chemistry.


CHEM 410. Instrumental Analytical Chemistry (3)
Principles and applications of analytical instrumentation including optical spectroscopy (UV-vis, IR, Raman), photoelectron and ion bombardment spectrometry, NMR and magnetic resonance imaging. Recommended preparation for CHEM 410: Two semesters of undergraduate physical chemistry.
Offered as CHEM 310 and CHEM 410.


CHEM 412. Advanced Inorganic Chemistry I (3)
Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. Recommended preparation: One semester of undergraduate inorganic chemistry and two semesters of physical chemistry.


CHEM 413. Advanced Inorganic Chemistry II (3)
Topics in mechanisms of inorganic reactions including ligand substitution, electron transfer, stereochemical interconversions, and catalytic pathways; supramolecular inorganic complexes and molecular devices.
Prereq: CHEM 412 or equivalent.


CHEM 414. Organometallic Reactions and Structures (3)
Bonding, structure, and mechanistic aspects of organometallic chemistry and the relevance of organometallic species to chemical catalysis. Recommended preparation: One semester of undergraduate inorganic chemistry.


CHEM 415. Chemical Applications of Group Theory (3)
Treatment of structure, bonding and spectroscopy in chemical systems based on a presentation of relationships and the theory of point and space groups.
Prereq: CHEM 412.


CHEM 421. Advanced Organic Chemistry I (3)
Structure, bonding, and molecular orbital theory. Stereochemistry and conformational analysis. Reaction mechanisms. Aromaticity and aromatic substitution. Pericyclic reactions, orbital symmetry conservation, and free radical chemistry. Recommended preparation: Two semesters of undergraduate organic chemistry.


CHEM 422. Advanced Organic Chemistry II (3)
Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Carbonyl reactions. Acyl transfer chemistry. Oxidations, reductions, and rearrangements.
Prereq: CHEM 421.


CHEM 425. Physical Methods for Determining Organic Structure (3)
Structure determination of organic compounds using mass spectrometry and modern instrumental techniques such as infrared, ultraviolet, visible, and nuclear magnetic resonance spectroscopy. Recommended preparation: Two semesters of organic chemistry.
Offered as CHEM 325 and CHEM 425.


CHEM 428. Introductory Biochemistry (3)
A survey of biochemistry with a strong emphasis on the chemical logic underlying metabolic pathways and the evolution of biomolecules. Cellular architecture. Amino acids and protein structure, purification, analysis, and synthesis. DNA, RNA, the flow of genetic information, and molecular biological technology. Enzyme kinetics, catalytic, and regulatory strategies. Sugars, complex carbohydrates, and glycoproteins. Lipids and cell membranes. Glycolysis, gluconeogenesis, carbon fixation through the “dark reactions” of photosynthesis, aerobic catabolism through the citric acid cycle, and glycogen metabolism. Biosynthesis and degradation of fatty acids, amino acids, and proteins.
Offered as CHEM 328 and CHEM 428.


CHEM 429. Chemical Aspects of Living Systems (3)
A survey of biochemical systems exploring their molecular circuitry and architecture. Protein structure and function. Lipids, cell membranes, channels and pumps. Redox processes and electron transport. Lipid and carbohydrate metabolism, its control, reciprocal regulation, and global integration. Nucleotide biosynthesis, DNA replication, recombination, and repair. RNA synthesis, splicing, and translation: protein synthesis and the control of gene expression. Sensory and immune systems. Molecular motors. Recommended preparation: Two semesters of organic chemistry. One semester of physical chemistry recommended.
Offered as CHEM 329 and CHEM 429.


CHEM 430. Advanced Methods in Structural Biology (3)
Provides students with an in-depth introduction to biophysical techniques used to quantify macromolecular structures. A major part of the course will deal with the use of nuclear magnetic resonance to derive a 3-D structures of macromolecules in solution. Other topics include electron spin resonance, absorption, fluorescence and circular dichroism spectroscopies, Raman and infrared spectroscopies and methods used in modeling. Offered with BIOC 431, “Advanced Methods Biology II” in alternate years. BIOC 430 deals with protein hydrodynamics and thermodynamics, crystallography, and mass spectrometry. The course will be mostly lecture based. This course will provide an extensive overview for graduate students specializing in structural biology.
Offered as BIOC 430, CHEM 430, PHOL 430 and PHRM 430.


CHEM 435. Synthetic Methods in Organic Chemistry (3)
Systematic consideration of reactions involving functional group transformations and carbon-carbon bond formations used in modern organic synthesis. Recommended preparation: Two semesters of undergraduate organic chemistry.


CHEM 436. Complex Molecular Synthesis (3)
An advanced organic chemistry course providing students with an in-depth examination of the art of total synthesis drawing from both classical and recent examples.
Prereq: CHEM 435.


CHEM 445. Electrochemistry I (3)
Electrochemical properties and processes of electrode/electrolyte interfaces. Fundamental background for work in corrosion, electrodeposition, industrial electrolysis, electro-organic synthesis, batteries, fuel cells, and photoelectrochemical energy conversion. Recommended preparation: One undergraduate course in physical chemistry and a working knowledge of thermodynamics.


CHEM 446. Quantum Mechanics I (3)
Introduction of quantization, measurement and the Schrodinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties. Recommended preparation: Two semesters of undergraduate physical chemistry.


CHEM 447. Quantum Mechanics II (3)
Continuation of CHEM 446. Ab initio and semi-empirical methods, configuration interactions, time dependent phenomena, and introduction to band theory of solids.
Prereq: CHEM 446.


CHEM 450. Molecular Spectroscopy (3)
Translation, rotation, vibration, and electronic transitions of molecules.
Prereq: CHEM 446.


CHEM 475. Protein Biophysics (3)
This course focuses on in-depth understanding of the molecular biophysics of proteins. Structural, thermodynamic and kinetic aspects of protein function and structure-function relationships will be considered at the advanced conceptual level. The application of these theoretical frameworks will be illustrated with examples from the literature and integration of biophysical knowledge with description at the cellular and systems level. The format consists of lectures, problem sets, and student presentations. A special emphasis will be placed on discussion of original publications.
Offered as BIOC 475, CHEM 475, PHOL 475, PHRM 475, and NEUR 475.


CHEM 491. Modern Chemistry for Innovation I (3)
The first half of a two-semester sequence providing an understanding of chemistry as a basis for successfully launching new high-tech ventures. The course will examine physical limitations to present technologies and the use of chemistry to identify potential opportunities for new venture creation. The course will provide experience in using chemistry for both identification of incremental improvements and as the basis for alternative technologies. Case studies will be used to illustrate recent commercially successful (and unsuccessful) venture creation and will illustrate characteristics for success. Admission to this course requires consent of the department.


CHEM 492. Modern Chemistry for Innovation II (3)
Continuation of CHEM 491, with an emphasis on current and prospective opportunities for Chemistry Entrepreneurship. Longer term opportunities for Chemistry Entrepreneurship in emerging areas, including (but not be limited to) biomaterials, pharmacogenomics, biocatalysis, and drug discovery.
Prereq: CHEM 491.


CHEM 493. Feasibility and Technology Analysis (3)
This course provides the tools scientists need to determine whether a technology is ready for commercialization. These tools include (but are not limited to): financial analysis, market analysis, industry analysis, technology analysis, intellectual property protection, the entrepreneurial process and culture, an introduction to entrepreneurial strategy and new venture financing. Deliverables will include a technology feasibility analysis on a possible application in the student’s scientific area.
Offered as BIOL 493, CHEM 493, and PHYS 493.


CHEM 501. Special Topics in Inorganic Chemistry (1–6)
(Credit as arranged.) Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 502. Special Topics in Inorganic Chemistry (1–6)
(Credit as arranged.) Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 503. Special Topics in Organic Chemistry (1–6)

(Credit as arranged.) Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 504. Special Topics in Organic Chemistry (1–6)
(Credit as arranged.) Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 505. Special Topics in Physical Chemistry (1–6)
(Credit as arranged.) Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 506. Special Topics in Physical Chemistry (1–6)
(Credit as arranged.) Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.


CHEM 507. Special Readings in Chemistry (1–6)
Detailed study of a special topic in chemistry under the guidance of a faculty member.


CHEM 508. Special Readings in Chemistry (1–6)
Detailed study of a special topic in chemistry under the guidance of a faculty member.


CHEM 509. Special Topics in Analytical Chemistry (1–6)


CHEM 511. Electrochemistry II (3)
Selected topics from electrocatalysis, semiconductor electrochemistry and photoelectrochemistry, and electrochemical impedance methods, as well as battery and fuel cell systems.
Prereq: CHEM 445.


CHEM 601. Research (1–18)
(Credit as arranged.) Special research in an area of chemistry under the guidance of a faculty member.


CHEM 605. Chemistry Colloquium Series (1)
Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.


CHEM 651. Thesis M.S. (1–18)
(Credit as arranged.)


CHEM 701. Dissertation Ph.D. (1–18)
(Credit as arranged.)
Prereq: Predoctoral research consent or advanced to Ph.D. candidacy milestone.