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Bone
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Mechanical Properties of Cancellous Bone
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Cancellous bone is the spongy mineralized tissue present at the ends of the long bones and throughout the spine. The mechanical properties of cancellous bone are determined through a combination of the complex trabecular microarchitecture as well as tissue properties. Ongoing work in the laboratory utilizes experimental and computational methods of analyzing cancellous bone structure and mechanics properties from the continuum scale (5mm in smallest dimension) to the microscopic scale.
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Images of individual trabeculae.
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Click to show tension testing of individual trabeculae.
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Bone Adaptation and Cancellous Bone Mechanics
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Bone remodeling is the primary process of changing bone mass, structure and mechanics in the adult body, making it an important regulator in the development of osteoporosis. Bone remodeling is controlled by highly non-linear feedback systems interacting through local stimuli such as mechanical loading as well as whole body stimuli such as circulating hormones. In this project we seek to determine how the bone remodeling process can influence cancellous bone mechanics, through changes in trabecular microarchitecture and tissue material properties.
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Remodeling cavities (shown in red) are added to a high-resolution image of cancellous bone for mechanical analysis.
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