Math 449

Lecture notes, Supplementary material, Mathematica nb

Introduction to biological systems.   Quick introduction to Mathematica  

Single population dynamics (Ch. 1)

    Discrete population growth

    Discrete dynamics: stability, bifurcation diagram & chaos

    Mathematica nb and links: Cobwebs; stability; power spectrum; Hassel map;

    Continuous population models

    Basic DE: logistic equation (data -calibration US population).

    Derivation of logistic and its modifications

    Bifurcations: Budworm infestation, (nb); Ludvig model

    Biological delays

    Differential-delay equations; stability analysis.nb; nonlinear DDE.nb. Metapopulations

    Structured populations

    Age structure (Leslie matrix, Euler-Lotka; McKendric approach)

    Discrete age + continuous time: notes, nb

    Notes on Laplace transform

    Stochastic populations: nb

    Working with population data: xls and nb (data for nb)

Population dynamics of interacting species (Ch.2)

    Host-parasitoid interactions: notes, nb

    Volterra - Lotka predator-prey (nb) and its extensions: notes, nb (phase-plane, equilibria, stability, bifurcations)

    Analysis of competition

Infectious diseases (Ch. 3)

    General intro (INTH 301/401, R. Blanton)

    Modeling (SEIR methodology): ppt, pdf . Notes on extended SIR

    Notebooks: Basic SIR; calibration, Contact pattern SIR

    Vector-borne diseases and macro-parasites: notes, nb

    In-host models (HIV and malaria)

    Evolutionary aspects ("virulent-bening" competition)

Population genetics and evolution (Ch.4)

    Mendelian genetics and selection (Hardy-Weinberg and FHW): nb.

    The balance between selection and mutation

    Evolution of genetic systems

    Additional topics: DNA and nucleotides. Lectures on population genetics

Biological motion (Ch. 5)

    Macroscopic theory of motion and Chemotaxis: Advection-diffusion, nb

    Biological invasion: plankton sedimentation. Transit time for diffusion

    Reaction-diffusion and FK traveling wave analysis; nb

Molecular and cellular biology (Ch. 6)

    Basic bio-chemistry; Michaelis-Menten approach; nb

    Additional notes on (i) Basic M-M as singular perturbation ; (ii) Cooperative and suiside substrate;

    Neural modeling (Hodgkin-Huxley and Fitzhugh-Nagumo): nb. Other examples (autocatalator.nb)

    Basic immunology and HIV/AIDS

Pattern formation in reacting systems (Ch.7)

    Turing instability in double-diffusive systems;

    LRA-SRI, bifurcations, color patterns; nb

    Autocatalytic reactions and chemical oscillators:

    Simple autocatalyzis, Volterra-Lotka, Brusselator (Turing patterns; nb)

    Belousosv-Zhabotinsky: theory and patterns; cellular automata BZ

    Chemotaxis (reaction with biological movement)

    patterns from J.D. Murray; analysis (notes); nb

Other links: Software
Medical dictionary Wolfram demonstration project
Cells and tissues  
Glossary of Genetic Terms  

 

David Gurarie

Mathematics, CWRU, Cleveland, OH 44106

E-mail: dxg5@case.edu