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Commentary on Gu, X., Zhang, W., Choi, J., Li, W., Chen, X., Laird, J. M. and Salomon, R. G. (2011) An (1)O(2) Route to gamma-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides. Chem Res Toxicol 24, 1080-1093.

Toxic γ-Hydroxyalkenals and the Retina


Commentary on Choi, J., Zhang, W., Gu, X., Chen, X., Hong, L., Laird, J. M. and Salomon, R. G. (2011) Lysophosphatidyl-choline is generated by spontaneous deacylation of oxidized phospholipids. Chem Res Toxicol 24, 111-118.

Fate of Oxidized Lipids


Commentaries on X. Z. West, N. L. Malinin, A. A. Merkulova, M. Tischenko, B. A. Kerr, E. C. Borden, E. A. Podrez, R. G. Salomon, T. V. Byzova (2010) Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467, 972–976.


A New Vein of TLR Biology

The Toll of Stress on Vessels


Commentary on Li, X. M., Salomon, R. G., Qin, J. and Hazen, S. L. (2007) Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36. Biochemistry 46, 5009-5017

Fat(al) attraction: oxidized lipids act as "eat-me" signals


Commentary on Podrez, E. A., Byzova, T. V., Febbraio, M., Salomon, R. G., Ma, Y., Valiyaveettil, M., Poliakov, E., Sun, M., Finton, P. J., Curtis, B. R., Chen, J., Zhang, R., Silverstein, R. L. and Hazen, S. L. (2007) Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 13, 1086-1095.

The clot thickens--oxidized lipids and thrombosis


Commentary in Case_The Value of Research (2007) highlighting our interdisciplinary research on eye diseases.

Chemistry and Biology Join Forces to Fight Eye Diseases


Commentary on Ebrahem, Q., Renganathan, K., Sears, J., Vasanji, A., Gu, X., Lu, L., Salomon, R. G., Crabb, J. W. and Anand-Apte, B. (2006) Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A 103, 13480-13484.

wet AMD: CEPsis of the retina?


Commentary on Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., Salomon, R. G. and Hollyfield, J. G. (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A 99, 14682-14687.

New insights and new approaches toward the study of age-related macular degeneration.

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