FACULTY & STAFF
Malcolm E. Kenney
Hinman Hurlbut Professor of Chemistry
(216) 368-3739
mek9@case.edu
Inorganic Chemistry
B.S., University of Redlands, 1950
Ph.D., Cornell University, 1954
Postdoctoral Associate, Cornell University, 1954
Drugs for Photodynamic Therapy.
Compounds of the phthalocyanine and napthalocyanine types are being synthesized and characterized for use in a cooperative research program on photodynamic therapy. The work is focused on the synthesis of compounds that have the desired light absorption, solubility, polarity, and stability. The compounds made are characterized by spectroscopy and then used in collaborative cell and animal studies. The work has resulted in a drug, Pc 4, which has been approved for use in Phase 1 human clinical trials with cancer patients.
Link to video of Pc 4 in Phase 1 clinical trials at University Hospitals Ireland Cancer Center.
Pc 4 - Clinical Trials
(Requires Windows Media Player 7.1 or better)
Audio description of the drug Pc 4
A New Synthetic Route to Organosilicon Compounds.
A new route to organosilicon compounds based on substitution reactions on silicates is being explored. The route differs from the conventional route to organosilicon compounds in that it does not depend on the reduction of silicon dioxide to silicon. The route offers access to new organosilicon compounds and has the potential to be more efficient than the traditional route.
Compounds for the Fabrication of Microelectronic Devices.
A program aimed at the synthesis and characterization of phthalocyanines and other complexes for use in the fabrication of microelectronic and molecular electronic devices is being carried out. Some of the phthalocyanines being made are designed to have the shape and polarity necessary to permit them to be deposited by the Langmuir-Blodgett technique as monolayers and multilayers on partially prefabricated chips. Emphasis is given in the work to the design and synthesis of useful compounds and to the characterization of these compounds.
Selected Publications:
- "The Peripheral Benzodiazepine Receptor in Photodynamic Therapy with the Phthalocyanine Photosensitizer Pc 4", Morris, Rachel L.; Varnes, Marie E.; Kenney, Malcolm E.; Li, Ying-Syi; Kashif, Azizuddin, Photochem. Photobiol. B 2002, 75, 652-661.
- "Synthesis and Characterization of Organosilicon Sheet and Tube Polymers", Chao, Timothy C.; Katsoulis, Dimitris, E.; Kenney, Malcolm E. Chem. Mater. 2001, 13, 4269-4277.
- "Synthesis and Excited State Dynamics of μ-Oxo Group IV Metal Phthalocyanine Dimers: A Laser Photoexcitation Study", Pelliccioli, A.P.; Henbest, K.; Kwag, G.; Carvagno, T. R.; Kenney, M. E.; Rodgers, M. A. J. J. Phys. Chem. A 2001, 105, 1757-1766.
- "Quantification of the Selective Retention of Palladium Octabutoxynapthalocyanine, a Potential Photothermal Drug, in Mouse Tissues", Bucking, M.; Dickson, E. F. G.; Farahani, M.; Fischer, F.; Holms, D.; Jori, G.; Kennedy, J. C.; Kenney, M. E.; Peng, X.; Pottier, R. H.; Weagle, g. J. Photochem. Photobiol. B 2000, 58, 87-43.
- "Synthesis and Characterization of Deep-Red Germanium Octabutoxynaphthalocyanine Photosensitizers", Cheng, G-Z.; Ji, Z-P.; Kenney, M. E. J. Wuhan Univ (Nat. Sci. Ed.) 2000, Mar, 54-46.
- "Photothermal Sensitization of Amelanotic Melanoma Cells by Ni(II) Octabutoxynaphthalocyanine", Busetti, A.; Soncin, M.; Reddi, E.; Rodgers, M. A. J.; Kenney, M. E.; Jori, G. J. Photochem. Photobiol. B 1999, 53, 103-109.
- "Hydrolyzed Portland Cement Clinker and Air-Cooled Blast Furnace Slag SO2 Sorbents", Hays, M. D.; Kenney, M. E. Proc. Annu. Int. Pittsburgh Coal Conf. 1999, 16th, 377-389.
- More Publications...