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Case Western Reserve University

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RECENT FACULTY & STAFF PUBLICATIONS 2010-2015

Listed alphabetically by PI

Hülya Bükülmez

Arnold I. Caplan

Diego Correa

Jonathan Kenyon

Donald P. Lennon

Rodrigo A. Somoza

J. Michael Sorrell

Jean F. Welter

TEA 2013 cover image from Chou et al.

Figure from:
Chou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.:
Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix.
Tissue Engineering, Part A 2013, 19(9-10):1081 - 1090.”
Abstract


Selected as cover art for "Tissue Engineering Part A - 2013".


Hülya Bükülmez, M.D.

Bükülmez, H.; Khan, F,; Bartels, C.F.; Murakami, S.; Ortiz-Lopez, A.; Sattar, A.; Haqqi, T.M.; and Warman, M.L.: Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in an inflammatory arthritis mouse model. Arthritis Rheum. 2013 Sep 24. doi: 10.1002/art.38199. [Epub ahead of print] Abstract
See supplemental data for this paper here

Bükülmez, H.; Wargula, J.; Bove, K.; Lovell, D.; and Griffin, T.: High dose corticosteroids may aggravate the vasculopathy that underlies ulcerative juvenile dermatomyositis. Journal of Rheumatology. (In Press)


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Arnold I. Caplan, Ph.D.

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 pii: S0165-2478(15)00103-0. doi: 10.1016/j.imlet.2015.06.005. [Epub ahead of print] Abstract

Caplan, A.I.: Adult mesenchymal stem cells and women's health. Menopause. 2015 (2):131-135. Abstract

Adorno-Cruz, V.; Kibria, G.; Liu, X.; Doherty, M.; Junk, D.J.; Guan, D.; Hubert, C.G.; Venere, M.; Mulkearns-Hubert, E.; Sinyuk, M.; Alvarado, A.; Caplan, A.I.; Rich, J.N.; Gerson, S.L.; Lathia, J.D.; and Liu, H.: Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015 pii: canres.3225.2014 Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage. 2015 23(3):443-53. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, 2014 20(6):596-608 Abstract

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue engineered constructs for a canine critical size cranial defect. Acta Biomaterialia, (Submitted 2014).

Sorrell, J.M. and Caplan, A.I.: Mesenchymal stem cells in skin and in the role of mesenchymal stem cells in cutaneous wound repair. J Invest Dermatol, (Submitted).

Bonfield, T.L.; Lennon, D.; and Caplan, A.I.: Human mesenchymal stem cells resolve infection and inflammation in pseudomonas aeruginosa infected cystic fibrosis transmembrane receptor knockout mice. Am J Physiol Lung Cell Mol Physiol, Submitted 2012.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract

Murphy, M.B.; Moncivais, K.; and Caplan, A,I.: Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 15;45:e54. doi: 10.1038/emm.2013.94. Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2014 22(1):160-168. Abstract

Dimarino, A.M.; Caplan, A.I.; and Bonfield, T.L.: Mesenchymal Stem Cells in Tissue Repair. Front Immunol. 2013 Sep 4;4:201. Review. Abstract

Kean, T.J.; Lin, P.; Caplan, A.I.; and Dennis, J.E.: MSCs: Delivery routes and engraftment, cell-targeting strategies, and immune modulation. Stem Cells Int. 2013;2013:732742. doi: 10.1155/2013/732742. Epub 2013 Aug 13. Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 Jul;34(23):5802-12 Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Eng, M.; Lennon, D.P.; Caplan, A.I.; and Bruder, A.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 Jun 10;319(10):1409-18. Abstract

Caplan, A.: MSCs as Therapeutics. In: Stem Cell Biology and Regenerative Medicine. Mesenchymal Stromal Cells: Biology and Clinical Applications, Stem Cell Biology and Regenerative Medicine. Hematti, P. and Keating, A. (Eds.), Springer Science+Business Media New York, Chapter 5. Accepted 2012.

Caplan, A.I.: MSCs: The New Medicine (invited chapter) In: Stem Cells in Regenerative Medicine: Science, Regulation, and Business Strategies. A Vertes (Eds), John Wiley & Sons, Ltd, Accepted 2012.

Caplan, A.I.: Mesenchymal Stem Cells in Regenerative Medicine. In: Handbook of Stem Cells, Vol 2, eds A Atala and R Lanza, eds. Academic Press, Chapter 43, Pp. 493-502 , 2012.

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: Pericytes as the source of mesenchymal stem cells. In: Resident Stem Cells and Regenerative Therapy, Goldenberg, R.C. and de Carvalho, A.C.C., eds. Elsevier Inc. Chapter 12, Pp. 233-250, 2012.

Caplan, A.I.: Adult mesenchymal stem cells and the NO pathways. Proceedings of the National Academy of Science U S A. 2013 110(8):2695-16956. Link

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. 2012 [Epub ahead of print] Abstract

Dong, F. and Caplan, A.I.: Cell transplantation as an initiator of endogenous stem cell-based tissue repair. Curr Opin Organ Transplant. 2012, 17(6):670-4. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract

Lizier, N.F.; Kerkis, A.; Gomes, C.M.; Hebling, J.; Oliveira, C.F.; Caplan, A.I.; and Kerkis, I." Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One. 2012;7(6):e39885. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract

Carrino, D.A.; Mesiano, S.; Barker, N.M.; Hurd, W.W.; and Caplan, A.I.: Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J. 2012, 443(2):361-8. Abstract

Kerkis, I. and Caplan, A.I.: Stem cells in dental pulp of deciduous teeth. Tissue Eng Part B Rev. 2012, 18(2):129-38. Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. Eur J Dermatol. 2011, 21(3):359-70. Abstract

Singer, N.G. and Caplan, A.I.: Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011, 28;6:457-78. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.P.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol. 2010, 299(6):L760-70. Abstract

Caplan, A.I.: What's in a name? Tissue Eng Part A. 2010, 16(8):2415-7.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Acute asthma: An in vivo model for human mesenchymal stem cell efficacy. J. Immunol Methods. Submitted 2009.

Bonfield, T.L. and Caplan, A.I.: Adult mesenchymal stem cells: An innovative therapeutic for lung diseases. Discov Med. 2010, 9(47):337-45. Abstract

Abrahamsson, C.; Yang, F.; Park, H.; Brunger, J.; Valonen, P.; Langer, R.; Welter, J.; Caplan, A.; Guilak, F.; and Freed L.: Chondrogenesis and mineralization with in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds, Tissue Engineering Part A. 2010, 16(12):3709-18. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discovery Medicine, 9(46):236-42. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Diekman, B.O.; Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Tiss Eng, Part A, 523-533, 2010

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Influence of Adult Mesenchymal Stem Cells on In Vitro Vascular Formation. In: Advances in Tissue Engineering, Volume 1: Angiogenesis. Chapter 24, Pp. 241-248, 2010.

Caplan, A.I.: Mesenchymal stem cells: The past, the present, the future. Cartilage 1(1)6-9, 2010.


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Diego Correa, M.D., M.Sc., Ph.D.

Correa, D.; Lin, P.; Rom, E.; Welter, J.; Duesler, L.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 (In press)

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2013 Sep 25. doi: 10.1038/mt.2013.221. [Epub ahead of print] Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Correa, D. and Segal, S.S.: Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation. 2012 May;19(4):306-15. doi: 10.1111/j.1549-8719.2012.00163.x. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal; 25(9): 3057-3067. Abstract

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010, 191(7):1271-1283. Abstract

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010, 19(4):533-546. Abstract

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010, 1192:32-37. Abstract


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Jonathan E. Kenyon, Ph.D.

Kenyon, J.; Fu, P.; Lingas, K.; Thomas, E.; Saurastri, A.; Santos Guasch, G.; Wald, D.; and Gerson, S.L.: Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012; 120(16):3229-36. Abstract


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Donald P. Lennon, D.D.S.

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue Engineered Constructs for a Canine Critical Size Cranial Defect. Acta Biomaterialia, Submitted 2012.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. 2014 Biofabrication 2014, 6(1):015003. doi: 10.1088/1758-5082/6/1/015003 Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 34(23):5802-12. Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Lennon, D.P.; Caplan, A.I; and Bruder, S.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 319(10):1409-18. Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010, 9(46):236-42. Abstract


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Rodrigo A. Somoza, Ph.D.

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. Journal of Experimental medicine, (2014) (submitted).

Somoza, R.A; Acevedo, C.A.; Weinstein-Oppenheimer, C.; Luz, P.A.; Carrión, F.; and Young, M.E.: TGF-ß3 secretion by human dental follicle mesenchymal stem cells (hDF-MSC) encapsulated in alginate and fibrin scaffolds. Journal of Tissue Engineering and Regenerative Medicine 2014 (in revision).

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of mesenchymal stem cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Acevedo, C.A.; Somoza, R.A.; Weinstein-Oppenheimer, C.; Silva, A.; Moreno, M.; Sanchez, E.; Albornoz, F.; Young, M.E.; MacNaughtan, W.; and Enrione, J. Improvement of human skin cells growth by radiation induced modifications of a Ge/Ch/Ha-scaffold. Bioprocess Biosyst Eng 2013 36:317–324. Abstract

Somoza, R.A. and Rubio, F.J: Cell therapy using induced pluripotent stem cells or somatic stem cells: this is the question. Current Stem Cell Research and Therapy. 2012 7(3):191-196. Abstract

Somoza, R.; Conget, P.; and Rubio, F.J.: Neuropotency of human mesenchymal stem cell cultures: Clonal studies reveal the contribution of cell plasticity and cell contamination. Biology of Blood and Marrow Transplantation 2012 14:546-555. Abstract

Acevedo, C.; Somoza, R.; Weinstein-Oppenheimer, C.; Brown, D.; and Young, M.: Growth factor production from fibrin-encapsulated human keratinocytes. Biotechnology Letters 2010 32:1011–1017. Abstract

Somoza, R.; Juri, C.; Baes, M; Wyneken, U.; and Rubio, F.J.: Intranigral transplantation of epigenetically-induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson´s disease. Biology of Blood and Marrow Transplantation 2010 16:1530-1540. Abstract

Enrione, J.; Osorio, F.; López, D.; Weinstein-Oppenheimer, C.; Fuentes, M.A.; Cereani, R.; Brown, D.I.; Albornoz, F.; Sánchez, E.; Villalobos, P.; Somoza, R.A.; Young, M.E.; and Acevedo, C.A.: Characterization of a gelatin/chitosan/hyaluronan scaffold-polymer. Electronic Journal of Biotechnology, 2010 DOI: 10.2225/vol13-issue5-fulltext-15.


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J. Michael Sorrell, Ph.D.

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 pii: S0165-2478(15)00103-0. doi: 10.1016/j.imlet.2015.06.005. [Epub ahead of print] Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract


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Jean F. Welter, M.D., M.Sc., Ph.D.

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 Jun 16. [Epub ahead of print]Abstract

Mansour, J.M.; Gu, D.-W.; Chung, C.-Y.; Heebner, J.; Schluchter, M.D.; and Welter, J.F.: Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of Biomedical Engineering 2014 (E-pub ahead of print) Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage. 2015 23(3):443-53. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, 2014 20(6):596-608 Abstract

Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014, (Submitted)

Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring shell thickness in engineered cartilage. (in revision)

Penick, K.J.; Solchaga, L.A.; Caplan A.I.; Goldberg, V.M.; and Welter, J.F.: Epitope retrieval for type X collagen detection. (in revision)

Holt, V.; Welter, J.F.; Berilla, J.A.; Harris, M.; and Caplan, A.I.: Cell capture apparatus and staining device. Provisional patent application number 61/875918 filed September 10, 2013.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract

Welter, J.F.; Solchaga, L.A.; Berilla, J.A.; and Penick, K.: Apparatus and method for tissue engineering. US Patent # 8,507,266 issued August 13, 2013.

Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013, 33(1):1-16 Abstract

Welter, J.F.; Penick, J.; Solchaga, L.A.: Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique Stem Cells International 2013:806525 Abstract

Bükülmez, H.; Bartels, C.F.; Nanda, K.; Haqqi, T.M.; and Welter, J.F.: Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model. Pediatric Rheumatology 2012, 10(Suppl 1):A109

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. 2012 [Epub ahead of print] Abstract

Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol. 2012;506:247-63. Abstract

Shao, Y.Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50(1):79-84. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annals of Biomed Eng. 2011, 39(10):2521-30 Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346-59 Abstract

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications. Methods in Molecular Biology. Humana Press, 2011:698:253-278. Abstract)

Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract

Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. Journal of Biomedical Materials Research, Part A 2010 94(4):1050 – 1060. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract


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