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Case Western Reserve University

SKELETAL RESEARCH
CENTER

 

RECENT FACULTY PUBLICATIONS 2006-2011

Hülya Bükülmez

Arnold I. Caplan

David A. Carrino

Diego Correa

James E. Dennis

Victor M. Goldberg

Donald P. Lennon

J. Michael Sorrell

Jean F. Welter

CTO 2008 cover image by Mike Sorrell

Figure from: "Sorrell, J.M., Baber, M.A., and Caplan, A.I.:
A Self-Assembled Fibroblast-Endothelial Cell Co-Culture System that Supports In Vitro Vasculogenesis by both Human Umbilical Vein Endothelial Cells and Human Dermal Microvascular Endothelial Cells. Cells, Tissues, Organs, 186:157-168, 2007.
"
Selected as cover art for "Cells Tissues, Organs - 2008".


Hülya Bükülmez, M.D.

Bükülmez, H.; Wargula, J.; Bove, K.; Lovell, D.; and Griffin, T.: High dose corticosteroids may aggravate the vasculopathy that underlies ulcerative juvenile dermatomyositis. Journal of Rheumatology. (In Press)

Matsushita, T.; Wilcox, W.R.; Chan, Y.Y.; Kawanami, A.; Bükülmez, H.; Balmes, G.; Krejci, P.; Mekikian, P.B.; Otani, K.; Yamaura, I.; Warman, M.L.; Givol, D.; and Murakami, S.: FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Human Molecular Genetics 2009 18(2):227-240. Abstract

Miles L, Bove KE, Lovell D, Wargula JC, Bükülmez, H., Shao, M.; Salisbury, S.; and Bean, J.A.: Predictability of the clinical course of juvenile dermatomyositis based on initial muscle biopsy: a retrospective study of 72 patients. Arthritis and Rheumatism 2007 Oct 15; 57(7):1183-91. Abstract

Bükülmez, H.; Matthews, A.; Sullivan, C.; Chen, C.; Kraay, M.; Elston, R.C.; Moskowitz, R.M.; Goldberg, V.M.; and Warman, M.L.: Familial aggregation of joint replacement surgery for idiopathic OA is present among individuals with hip replacement, but not knee replacement. Arthritis Research & Therapy,2006;8(1):R25. Abstract


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Arnold I. Caplan, Ph.D.

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. Eur J Dermatol. 2011, 21(3):359-70. Abstract

Singer, N.G. and Caplan, A.I.: Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011, 28;6:457-78. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.P.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol. 2010, 299(6):L760-70. Abstract

Caplan, A.I.: What's in a name? Tissue Eng Part A. 2010, 16(8):2415-7.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Acute asthma: An in vivo model for human mesenchymal stem cell efficacy. J. Immunol Methods. Submitted 2009.

Bonfield, T.L. and Caplan, A.I.: Adult mesenchymal stem cells: An innovative therapeutic for lung diseases. Discov Med. 2010, 9(47):337-45. Abstract

Abrahamsson, C.; Yang, F.; Park, H.; Brunger, J.; Valonen, P.; Langer, R.; Welter, J.; Caplan, A.; Guilak, F.; and Freed L.: Chondrogenesis and mineralization with in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds, Tissue Engineering Part A. 2010, 16(12):3709-18. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discovery Medicine, 9(46):236-42. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Diekman, B.O.; Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Tiss Eng, Part A, 523-533, 2010

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Influence of Adult Mesenchymal Stem Cells on In Vitro Vascular Formation. In: Advances in Tissue Engineering, Volume 1: Angiogenesis. Chapter 24, Pp. 241-248, 2010.

Caplan, A.I.: Mesenchymal stem cells: The past, the present, the future. Cartilage 1(1)6-9, 2010.

Caplan, A.I.: New era of cell-based orthopaedic therapies. Tissue Engineering, Part B, 15(2):195-200, 2009. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, Epub ahead of print 2009. Abstract

Caplan, A.I.: Why are MSCs therapeutic? New data: new insight. Journal of Pathology, 217:318-324, 2009. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A, Volume 15, Epub ahead of print, 2009. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15:313-318, 2009. Abstract

Park, H.; Guo, X.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Kasper, F.K.; and Mikos, A.G.: Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules, 10:541-546, 2009. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Raphael, R.M.; Jansen, J.A.; and Mikos, A.G.: Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of Biomedical Materials Research, Part A, 88(4):889-897, 2009. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research, 27(2):216-221, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology, (Submitted), 2009.

Butler, D.L; Lewis, J.F.; Frank, C.B; Banes, A.J.; Caplan, A.I.; de Deyne, P.G. et al.: Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: A conference report. Tissue Engineering, Part A 14(12): 2089-2104, 2008.

Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Caplan, A.I.: All MSCs are pericytes? Cell Stem Cell, 3(3):229-30, 2008. Abstract

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: The mesenchymal stem cell niche. 2007 (Submitted).

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26:2287-2299, 2008. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16(2):300-9. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract

Caplan, A.I.: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cell Physiology 2007, 213:341-347. Abstract

Gao, J.; Yao, J.Q.; and Caplan, A.I.: Stem cells for tissue engineering of articular cartilage. Proceedings of the Institute of Mechanical Engineers 2007, 221:441-450. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocyte from three anatomic locations in the rabbit. Tissue Engineering 2007, 13:843-853. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; and Mikos, A.G.: Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 2007, 28:3217-3227. Abstract

Kerkis, I.; Kerkis, A.; Dozortsev, D.; Stukart-Parsons, G.C.; Gomes-Massironi, S.M.; Pereira, L.V.; Caplan, A.I.; and Cerruti, H.F.: Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs 2006, 184(3-4):105-16. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.L.; and Miller, R.H.: Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult dermis. Cell and Tissue Research 2007, 327:499-510. Abstract


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David A. Carrino, Ph.D.

Engle, J.M.; Carrino, D.A.; Caplan, A.I.; and Apte, S.S.: Analysis of proteoglycans from human placenta. (In preparation).

Hattori, N.; Carrino, D.A.; Lauer, M.E.; Vasanji, A.; Wylie, J.D.; Nelson, C.M.; and Apte, S.S.: Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem. 2011, 286(39):34298-310. Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. Eur J Dermatol. 2011, 21(3):359-70. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related changes in the proteoglycans of human skin: versican and decorin. Glycobiology. 2011 21(2):257-68. Abstract


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Diego Correa, M.D., M.Sc., Ph.D.

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal; 25(9): 3057-3067. Abstract

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010, 191(7):1271-1283. Abstract

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010, 19(4):533-546. Abstract

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010, 1192:32-37. Abstract


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James E. Dennis, Ph.D.

Gilpin, D.A.; Weidenbecher, M.S.; and Dennis, J.E.: Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstruction. Laryngoscope 2010 [Epub ahead of print] Abstract

Henderson, J.H.; Ginley, N.M.; Caplan, A.I.; Niyibizi, C.; and Dennis, J.E.: Low Oxygen Tension During Incubation Periods of Chondrocyte Expansion Is Sufficient to Enhance Postexpansion Chondrogenesis. Tissue Eng Part A 2010 [Epub ahead of print] Abstract

Weidenbecher, M.; Tucker, H.M.; Gilpin, D.A.; and Dennis, J.E.: Tissue-engineered trachea for airway reconstruction. Laryngoscope 2009, 119(11):2118-23. Abstract

Wagner, J.; Kean, T.; Young, R.; Dennis, J.E.; and Caplan, A.I.: Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol 2009 20(5):531-6. Abstract

van Osch, G.J.; Brittberg, M.; Dennis, J.E.; Bastiaansen-Jenniskens, Y.M.; Erben, R.G.; Konttinen, Y.T.; and Luyten, F.P.: Cartilage repair: past and future--lessons for regenerative medicine. J Cell Mol Med 2009, 13(5):792-810. Abstract

Ko, I.K.; Kean, T.J.; and Dennis, J.E.: Targeting mesenchymal stem cells to activated endothelial cells. Biomaterials 2009, 30(22):3702-10. Abstract

Song I.H.; Caplan A.I.; and Dennis, J.E.: In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. Journal of Orthopedic Research 2009, 27(7):916-21. Abstract

Wang, F.; Dennis, J.E.; Awadallah, A.; Solchaga, L.A.; Molter, J.; Kuang, Y.; Salem, N.; Lin, Y.; Tian, H.; Kolthammer, J.A.; Kim, Y.; Love, Z.B.; Gerson, S.L.; and Lee, Z.: Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiol Genomics 2009, 7(1):23-34. Abstract

Moioli E.K.; Clark P.A.; Chen M.; Dennis J.E.; Erickson H.P.; Gerson S.L.; and Mao J.J.: Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. PLoS One 2008, 3(12):e3922. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research 2009, 27(2):216-221. Abstract

Lee, Z.; Dennis, J.E.; and Gerson, S.L.: Imaging stem cell implant for cellular-based therapies. Experimental Biology & Medicine 2008 (Epub ahead of print). Abstract

Weidenbecher, M.; Tucker, H.M.; Awadallah, A.; and Dennis, J.E.: Fabrication of a neotrachea using engineered cartilage. Laryngoscope 2008, 118(4):593-8. Abstract

Dennis, J.E.; Esterly, K.; Awadallah, A.; Parrish, C.R.; Poynter, G.M.; and Goltry, K.L.: Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration. Stem Cells 2007, 25(10):2575-82. Abstract

Chen, X.; Song, I.H.; Dennis, J.E.; and Greenfield, E.M.: Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts. Journal of Bone & Minereral Research 2007, 22(5):656-64. Abstract

Love, Z.; Wang, F.; Dennis, J.; Awadallah, A.; Salem, N.; Lin, Y.; Weisenberger, A.; Majewski, S.; Gerson, S.; and Lee, Z.: Imaging of mesenchymal stem cell transplant by bioluminescence and PET. Journal of Nuclear Medicine 2007, 48:2011-2020. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843-53. Abstract

Weidenbecher, M.; Henderson, J.H.; Tucker, H.M.; Baskin, J.Z.; Awadallah, A.; and Dennis, J.E.: Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction. Laryngoscope 2007, 117(10):1745-9. Abstract

Caplan, A.I. and Dennis, J.E.: Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 2006, 98:1076-1084. Abstract


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Victor M. Goldberg, M.D.

Bonsignore, L.A.; Colbrunn, R.W.; Tatro, J.M.; Messerschmitt, P.J.; Hernandez, C.J.; Goldberg, V.M.; Stewart, M.C.; and Greenfield, E.M.: Surface contaminants inhibit osseointegration in a novel murine model. Bone. 2011, 49(5):923-30. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Medel, F.J.; Kurtz, S.M.; Sharkey, P.F.; Austin, M.S.; Klein, G.R.; Cohen, A.R.; Patel, H.; Goldberg, V.M.; Kraay, M.J.; and Rimnac, C.M.: Post damage in contemporary posterior-stabilized tibial inserts: influence of implant design and clinical relevance. J Arthroplasty. 2011, 26(4):606-14. Abstract

Goldberg, V.M.; Buckwalter, J.; Halpin, M.; Jiranek, W.; Mihalko, W.; Pinzur, M.; Rohan, B.; Vail, T.; Walker, P.; Windsor, R.; and Wright, T: Recommendations of the OARSI FDA Osteoarthritis Devices Working Group. Osteoarthritis Cartilage. 2011 19(5):509-14 Abstract

Fitzgerald, S.J.; McAndrew, C.M.; Kraay, M.J.; and Goldberg, V.M.: Incidence of postthrombotic syndrome in patients undergoing primary total hip arthroplasty for osteoarthritis. Clin Orthop Relat Res. 2011 469(2):530-4. Abstract

Greenfield, E.M.; Beidelschies, M.A.; Tatro, J.M.; Goldberg, V.M.; and Hise, A.G.: Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010 285(42):32378-84 Abstract

Wera, G.D.; Gillespie, R.J.; Petty, C.; Petersilge, W.J.; Kraay, M.J.; and Goldberg, V.M.: Revision of hip resurfacing arthroplasty. Am J Orthop (Belle Mead NJ). 2010 39(8):E78-83. Abstract

Furmanski, J. and Goldberg, V.M.: Commentary on an article by B.H. Currier, MChE, et al.: "In vivo oxidation in remelted highly cross-linked retrievals". J Bone Joint Surg Am. 2010 92(14):e23. Abstract

Goldberg, V.M. and Goldberg, L.: Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis. J Pain Res. 2010, 3:51-56. Abstract

Furmanski, J. and Goldberg, V,M.: Commentary on an article by B.H. Currier, MChE, et al.: "In vivo oxidation in remelted highly cross-linked retrievals". J Bone Joint Surg Am. 2010, 92(14):e23.

Wera, G.D.; Gillespie, R.J.; Petty, C.; Petersilge, W.J.; Kraay, M.J.; and Goldberg, V.M.: Revision of hip resurfacing arthroplasty. Am J Orthop (Belle Mead NJ). 2010, 39(8):E78-83. Abstract

Fitzgerald, S.J.; McAndrew, C.M.; Kraay, M.J.; and Goldberg, V.M.: Incidence of postthrombotic syndrome in patients undergoing primary total hip arthroplasty for osteoarthritis. Clin Orthop Relat Res. 2011, 469(2):530-534. Abstract

Greenfield, E.M.; Beidelschies, M.A.; Tatro, J.M.; Goldberg, V.M.; and Hise A.G.: Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010, 285(42):32378-84. Abstract

Marulanda, G.A.; Krebs, V.E.; Bierbaum, B.E.; Goldberg, V.M.; Ries, M.; Ulrich, S.D.; Seyler, T.M.; and Mont, M.A.: Hemostasis using a bipolar sealer in primary unilateral total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2009, 38(12):E179-83. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Eng Part A. 2010 16(3):1009-19. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated Resurfacing of the Previously Unresurfaced Patella Total Knee Arthroplasty. Journal of Arthroplasty 2010, 25(5):754-8. Abstract

Hartzband, M.A.; Glassman, A.H.; Goldberg, V.M.; Jordan, L.R.; Crowninshield, R.D.; Fricka, K.B.; and Jordan, L.C.: Survivorship of a Low-stiffness Extensively Porous-coated Femoral Stem at 10 Years. Clin Orthopædics and Related Research 2010, 468(2):433-40. Abstract

McAndrew, C.M.; Fitzgerald, S.J.; Kraay, M.J.; and Goldberg V.M.: Incidence of Postthrombotic Syndrome in Patients Undergoing Primary Total Knee Arthroplasty for Osteoarthritis. Clin Orthopædics and Related Research 2010, 468(1):178-81. Abstract

Garcia, R.M.; Kraay, M.J.; Messerschmitt, P.J.; Goldberg, V.M.; and Rimnac, C.M.: Analysis of retrieved ultra-high-molecular-weight polyethylene tibial components from rotating-platform total knee arthroplasty. Journal of Arthroplasty 2009, 24(1):131-8. Abstract

Garcia, R.M.; Kraay, M.J.; Conroy-Smith, P.A.; and Goldberg, V.M.: Management of the deficient patella in revision total knee arthroplasty. Clin Orthopædics and Related Research 2008, 466(11):2790-7. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated all-polyethylene patellar revisions for metal-backed patellar failure. Clin Orthopædics and Related Research 2008, 466(11):2784-9. Abstract

Beidelschies, M.A.; Huang, H.; McMullen, M.R.; Smith, M.V.; Islam, A.S.; Goldberg, V.M.; Chen, X.; Nagy, L.E.; and Greenfield, E.M.: Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. Journal of Cell Physiology 2008 217(3):652-66. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Retention of superficially damaged femoral components after metal-backed patella component failure. Journal of Arthroplasty 2008, 23(6):850-8. Abstract

Goldberg, V.M.: Contemporary total joint arthroplasty. North Carolina Medical Journal 2007, 68(6):447-50. Abstract

Mont, M.A.; Seyler, T.M.; Ulrich, S.D.; Beaule, P.E.; Boyd, H.S.; Grecula, M.J.; Goldberg, V.M.; Kennedy, W.R.; Marker, D.R.; Schmalzried, T.P.; Sparling, E.A.; Vail, T.P.; and Amstutz, H.C.: Effect of changing indications and techniques on total hip resurfacing. Clinical Orthopædics & Related Research 2007, 465:63-70. Abstract

Akhavan, S. and Goldberg, V.M.: Clinical outcome of a fibermetal taper stem: minimum 5-year followup. Clinical Orthopædics & Related Research 2007, 465:106-11. Abstract

Taki, N.; Tatro, J.M.; Lowe, R.; Goldberg, V.M.; and Greenfield, E.M.: Comparison of the roles of IL-1, IL-6, and TNF-α in cell culture and murine models of aseptic loosening. Bone 2007, 40:1276-1283. Abstract

Smith, M.V.; Lee, M.J.; Islam, A.S.; Rohrer, J.L.; Goldberg, V.M.; Beidelschies, M.A.; and Greenfield, E.M.: Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-α production in response to titanium particles in vitro. Journal of Bone & Joint Surgery Am 2007, 89:1019-1027. Abstract

Tatro, J.M.; Taki, N.; Islam, A.S.; Goldberg, V.M.; Rimnac, C.M.; Doerschuk C.M.; Stewart, M.C.; and Greenfield, E.M.: The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Journal of Orthopædic Research 2007, 25:361-369. Abstract

Deglurkar, M.; Davy, D.T.; Stewart, M.; Goldberg, V.M.; and Welter, J.F.: Evaluation of machining methods for trabecular metal implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research Part B - Applied Biomaterials 2007,80:528-540. Abstract


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Donald P. Lennon, D.D.S.

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51.Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010, 9(46):236-42. Abstract

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 2009, 15;57(11):1192-203. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15, 313-318, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.P.; and Miller, R.: Mesenchymal stem cell signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Lennon, D.P. and Caplan, A.I.: Mesenchymal stem cells for tissue engineering. In: Culture of Cells for Tissue Engineering, edited by I. Freshney and G. Vunjak-Novakovic, 2006 John Wiley and Sons, Hoboken, NJ. Buy

Lennon, D.P. and Caplan, A.I.: Isolation of rat marrow-derived mesenchymal stem cells. Experimental Hematology 2006, 34:1606-1607. Abstract

Lennon, D.P. and Caplan, A.I.: Isolation of human marrow-derived mesenchymal stem cells. Experimental Hematology 2006, 34:1604-1605. Abstract


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J. Michael Sorrell, Ph.D.

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology 2009, 276:161-214. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A 2009, 15(7):1751-61. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations: differential interactions with vascular endothelial cells in co-culture. Non-soluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16:300-309. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult human dermis. Cell & Tissue Resarch 2007, 327:499-510. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A Self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract


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Jean F. Welter, M.D., M.Sc., Ph.D.

Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring shell thickness in engineered cartilage. (in revision)

Penick, K.J.; Solchaga, L.A.; Caplan A.I.; Goldberg, V.M.; and Welter, J.F.: Epitope retrieval for type X collagen detection. (in revision)

Shao, Y.Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone. 2011 Sep 10. [Epub ahead of print] Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346-59 Abstract

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications. Methods in Molecular Biology. Humana Press, 2011:698:253-278. Abstract)

Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract

Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Optimizing collagen-GAG scaffolds for tissue engineering applications using centrifugation. Journal of Biomedical Materials Research (A) Journal of Biomedical Materials Research, Part A 2010 94(4):1050 – 1060. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

Welter, J.F.; Solchaga, L.A.; and Penick, K.J.: Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. BioTechniques 2007, 42(6):732 – 737. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843 – 853. Abstract

Deglurkar, M.; Davy, D.T.; Goldberg, V.M.; Stewart, M.C.; and Welter, J.F.: Evaluation of machining methods for porous tantalum implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research (B) 2007, 80B(2):528 – 540. Abstract

Henderson, J.H.; Mansour, J.M.; Welter, J.F.; Awadallah, A.; Ginley, N.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering: comparison of chondrocytes from three anatomic locations in the rabbit. CWRU Orthopædic Journal 2006, 3(1):33- 42.

Solchaga, L.A.; Tognana, E.; Penick, K.; Baskaran, H.; Caplan, A.I.; Goldberg, V.G.; and Welter, J.F.: A rapid vacuum-seeding technique for the assembly of large tissue-engineered cell/scaffold composites. Tissue Engineering 2006, 12(7):1851 – 1863. Abstract

Wenger, R.; Hans, M.G.; Welter, J.F.; Solchaga, L.A.; Sheu, Y.R.; and Malemud, C.J.: Tissue-engineered human cartilage-constructs from human osteoarthritic chondrocytes. Frontiers in Biosciences 2006, 11:1690 – 1695. Abstract

Goldberg, V.M. and Welter, J.F.: Autografts. In: Callaghan, J.J.; Rosenberg, A.G.; and Rubash, H.E., eds.: The adult hip, Lippincott-Raven. 2006(23):304 - 328. Buy


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