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Case Western Reserve University

SKELETAL RESEARCH
CENTER

 

RECENT FACULTY PUBLICATIONS 2006-2008

Hülya Bükülmez

Arnold I. Caplan

David A. Carrino

James E. Dennis

Victor M. Goldberg

Donald P. Lennon

Durba Mukhopadhyay

Luis A. Solchaga

J. Michael Sorrell

Jean F. Welter

CTO 2008 cover image by Mike Sorrell

Figure from: "Sorrell, J.M., Baber, M.A., and Caplan, A.I.:
A Self-Assembled Fibroblast-Endothelial Cell Co-Culture System that Supports In Vitro Vasculogenesis by both Human Umbilical Vein Endothelial Cells and Human Dermal Microvascular Endothelial Cells. Cells, Tissues, Organs, 186:157-168, 2007.
"
Selected as cover art for "Cells Tissues, Organs - 2008".


Hülya Bükülmez, M.D.

Bükülmez, H.; Wargula, J.; Bove, K.; Lovell, D.; and Griffin, T.: High dose corticosteroids may aggravate the vasculopathy that underlies ulcerative juvenile dermatomyositis. Journal of Rheumatology. (In Press)

Matsushita, T.; Wilcox, W.R.; Chan, Y.Y.; Kawanami, A.; Bükülmez, H.; Balmes, G.; Krejci, P.; Mekikian, P.B.; Otani, K.; Yamaura, I.; Warman, M.L.; Givol, D.; and Murakami, S.: FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Human Molecular Genetics 2009 18(2):227-240. Abstract

Miles L, Bove KE, Lovell D, Wargula JC, Bükülmez, H., Shao, M.; Salisbury, S.; and Bean, J,A.: Predictability of the clinical course of juvenile dermatomyositis based on initial muscle biopsy: a retrospective study of 72 patients. Arthritis and Rheumatism 2007 Oct 15; 57(7):1183-91. Abstract

Bükülmez, H.; Matthews, A.; Sullivan, C.; Chen, C.; Kraay, M.; Elston, R.C.; Moskowitz, R.M.; Goldberg, V.M.; and Warman, M.L. Familial aggregation of joint replacement surgery for idiopathic OA is present among individuals with hip replacement, but not knee replacement Arthritis Research & Therapy,2006;8(1):R25. Abstract


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Arnold I. Caplan, Ph.D.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. American Journal of Respiratory Cell and Molecular Biology, 2009 (in review).

Caplan, A.I.: New era of cell-based orthopaedic therapies. Tissue Engineering, Part B, 2009 (in press). Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Journal of Cell Physiology, 2009 (submitted).

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, Epub ahead of print 2009. Abstract

Caplan, A.I.: Why are MSCs therapeutic? New data: new insight. Journal of Pathology, 217:318-324, 2009. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A, Volume 15, Epub ahead of print, 2009. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15, 313-318, 2009. Abstract

Park, H.; Guo, X.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Kasper, F.K.; and Mikos, A.G.: Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules, 10:541-546, 2009. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Raphael, R.M.; Jansen, J.A.; and Mikos, A.G.: Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of Biomedical Materials Research, Part A, 88(4):889-897, 2009. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research, 27(2):216-221, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology, (Submitted), 2009.

Butler, D.L; Lewis, J.F.; Frank, C.B; Banes, A.J.; Caplan, A.I.; de Deyne, P.G. et al.: Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: A conference report. Tissue Engineering, Part A 14(12): 2089-2104, 2008.

Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Caplan, A.I.: All MSCs are pericytes? Cell Stem Cell, 3(3):229-30, 2008. Abstract

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: The mesenchymal stem cell niche. 2007 (Submitted).

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26:2287-2299, 2008. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16(2):300-9. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract

Caplan, A.I.: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cell Physiology 2007, 213:341-347. Abstract

Gao, J.; Yao, J.Q.; and Caplan, A.I.: Stem cells for tissue engineering of articular cartilage. Proceedings of the Institute of Mechanical Engineers 2007, 221:441-450. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocyte from three anatomic locations in the rabbit. Tissue Engineering 2007, 13:843-853. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; and Mikos, A.G.: Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 2007, 28:3217-3227. Abstract

Kerkis, I.; Kerkis, A.; Dozortsev, D.; Stukart-Parsons, G.C.; Gomes-Massironi, S.M.; Pereira, L.V.; Caplan, A.I.; and Cerruti, H.F.: Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs 2006, 184(3-4):105-16. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.L.; and Miller, R.H.: Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult dermis. Cell and Tissue Research 2007, 327:499-510. Abstract


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David A. Carrino, Ph.D.

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related changes in the proteoglycans of human skin: versican and decorin. 2007 (In preparation).

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Effect of a β-xyloside-like compound on wound healing. 2007 (In preparation).

Engle, J.M.; Carrino, D.A.; Caplan, A.I.; and Apte, S.S.: Analysis of proteoglycans from human placenta. 2007 (In preparation).


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James E. Dennis, Ph.D.

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research, 27(2):216-221, 2009. Abstract

Lee, Z.; Dennis, J.E.; and Gerson, S.L.: Imaging stem cell implant for cellular-based therapies. Experimental Biology & Medicine 2008 (Epub ahead of print). Abstract

Weidenbecher, M.; Tucker, H.M.; Awadallah, A.; and Dennis, J.E.: Fabrication of a neotrachea using engineered cartilage. Laryngoscope 2008 (Epub ahead of print). Abstract

Dennis, J.E.; Esterly, K.; Awadallah, A.; Parrish, C.R.; Poynter, G.M.; and Goltry, K.L.: Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration. Stem Cells 2007, 25(10):2575-82. Abstract

Chen, X.; Song, I.H.; Dennis, J.E.; and Greenfield, E.M.: Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts. Journal of Bone & Minereral Research 2007, 22(5):656-64. Abstract

Love, Z.; Wang, F.; Dennis, J.; Awadallah, A.; Salem, N.; Lin, Y.; Weisenberger, A.; Majewski, S.; Gerson, S.; and Lee, Z.: Imaging of mesenchymal stem cell transplant by bioluminescence and PET. Journal of Nuclear Medicine 2007, 48:2011-2020. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843-53. Abstract

Weidenbecher, M.; Henderson, J.H.; Tucker, H.M.; Baskin, J.Z.; Awadallah, A.; and Dennis, J.E.: Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction. Laryngoscope 2007, 117(10):1745-9. Abstract

Caplan, A.I. and Dennis, J.E.: Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 2006, 98:1076-1084. Abstract


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Victor M. Goldberg, M.D.

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Journal of Cell Physiology, 2009 (submitted).

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated Resurfacing of the Previously Unresurfaced Patella Total Knee Arthroplasty. Journal of Arthroplasty 2009, [Epub ahead of print] Abstract

Hartzband, M.A.; Glassman, A.H.; Goldberg, V.M.; Jordan, L.R.; Crowninshield, R.D.; Fricka, K.B.; and Jordan, L.C.: Survivorship of a Low-stiffness Extensively Porous-coated Femoral Stem at 10 Years. Clin Orthopædics and Related Research 2009, [Epub ahead of print] Abstract

McAndrew, C.M.; Fitzgerald, S.J.; Kraay, M.J.; and Goldberg V.M.: Incidence of Postthrombotic Syndrome in Patients Undergoing Primary Total Knee Arthroplasty for Osteoarthritis. Clin Orthopædics and Related Research 2009, [Epub ahead of print] Abstract

Garcia, R.M.; Kraay, M.J.; Messerschmitt, P.J.; Goldberg, V.M.; and Rimnac, C.M.: Analysis of retrieved ultra-high-molecular-weight polyethylene tibial components from rotating-platform total knee arthroplasty. Journal of Arthroplasty 2009, 24(1):131-8. Abstract

Garcia, R.M.; Kraay, M.J.; Conroy-Smith, P.A.; and Goldberg, V.M.: Management of the deficient patella in revision total knee arthroplasty. Clin Orthopædics and Related Research 2008, 466(11):2790-7. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated all-polyethylene patellar revisions for metal-backed patellar failure. Clin Orthopædics and Related Research 2008, 466(11):2784-9.Abstract

Beidelschies, M.A.; Huang, H.; McMullen, M.R.; Smith, M.V.; Islam, A.S.; Goldberg, V.M.; Chen, X.; Nagy, L.E.; and Greenfield, E.M.: Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. Journal of Cell Physiology 2008 217(3):652-66. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Retention of superficially damaged femoral components after metal-backed patella component failure. Journal of Arthroplasty 2008, 23(6):850-8. Abstract

Goldberg, V.M.: Contemporary total joint arthroplasty. North Carolina Medical Journal 2007, 68(6):447-50. Abstract

Mont, M.A.; Seyler, T.M.; Ulrich, S.D.; Beaule, P.E.; Boyd, H.S.; Grecula, M.J.; Goldberg, V.M.; Kennedy, W.R.; Marker, D.R.; Schmalzried, T.P.; Sparling, E.A.; Vail, T.P.; and Amstutz, H.C.: Effect of changing indications and techniques on total hip resurfacing. Clinical Orthopædics & Related Research 2007, 465:63-70. Abstract

Akhavan, S. and Goldberg, V.M.: Clinical outcome of a fibermetal taper stem: minimum 5-year followup. Clinical Orthopædics & Related Research 2007, 465:106-11. Abstract

Taki, N.; Tatro, J.M.; Lowe, R.; Goldberg, V.M.; and Greenfield, E.M.: Comparison of the roles of IL-1, IL-6, and TNF-α in cell culture and murine models of aseptic loosening. Bone 2007, 40:1276-1283. Abstract

Smith, M.V.; Lee, M.J.; Islam, A.S.; Rohrer, J.L.; Goldberg, V.M.; Beidelschies, M.A.; and Greenfield, E.M.: Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-α production in response to titanium particles in vitro. Journal of Bone & Joint Surgery Am 2007, 89:1019-1027. Abstract

Tatro, J.M.; Taki, N.; Islam, A.S.; Goldberg, V.M.; Rimnac, C.M.; Doerschuk C.M.; Stewart, M.C.; and Greenfield, E.M.: The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Journal of Orthopædic Research 2007, 25:361-369. Abstract

Deglurkar, M.; Davy, D.T.; Stewart, M.; Goldberg, V.M.; and Welter, J.F.: Evaluation of machining methods for trabecular metal implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research Part B - Applied Biomaterials 2007,80:528-540. Abstract


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Donald P. Lennon, D.D.S.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. American Journal of Respiratory Cell and Molecular Biology, 2009 (in review).

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, Epub ahead of print 2009. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15, 313-318, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.P.; and Miller, R.: Mesenchymal stem cell signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Lennon, D.P. and Caplan, A.I.: Mesenchymal stem cells for tissue engineering. In: Culture of Cells for Tissue Engineering, edited by I. Freshney and G. Vunjak-Novakovic, 2006 John Wiley and Sons, Hoboken, NJ. Buy

Lennon, D.P. and Caplan, A.I.: Isolation of rat marrow-derived mesenchymal stem cells. Experimental Hematology 2006, 34:1606-1607. Abstract

Lennon, D.P. and Caplan, A.I.: Isolation of human marrow-derived mesenchymal stem cells. Experimental Hematology 2006, 34:1604-1605. Abstract


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Durba Mukhopadhyay, Ph.D.

Nigro, J.; Wang, A.; Mukhopadhyay, D.; Lauer, M.E.; Midura, R.J.; Sackstein, R.; and Hascall, V.C.: Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells. Journal of Biological Chemistry 2009, 284(25):16832-9. Abstract

Lauer, M.E.; Mukhopadhyay, D.; Fulop, C.; de la Motte, C.A.; Majors, A.K.; and Hascall, V.C.: Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. Journal of Biological Chemistry 2009, 284(8):5299-312. Abstract

Lauer, M.E.; Fulop, C.; Mukhopadhyay, D.; Comhair, S.; Erzurum, S.C.; and Hascall, V.C.: Airway smooth muscle cells synthesize hyaluronan cable structures independent of inter-{alpha}-inhibitor heavy chain attachment. Journal of Biological Chemistry 2009, 284(8):5313-23. Abstract

Lauer, M.E.; Erzurum, S.C.; Mukhopadhyay, D.; Vasanji, A.; Drazba, J.; Wang, A.; Fullop, C.; and Hascall, V.C.: Differentiated murine airway epithelial cells synthesize a leukocyte-adhesive hyaluronan matrix in response to endoplasmic reticulum stress. Journal of Biological Chemistry 2008, 283(38):26283-96. Abstract


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Luis A. Solchaga, Ph.D.

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications (submitted)

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Journal of Cell Physiology, 2009 (submitted).

Maitra, B.; Szekely, E.; Solchaga, L.A.; and Auletta, J.J.: Immunomodulatory effects of ex vivo Toll-like receptor stimulation of human bone-marrow derived mesenchymal stem cells (MSCs). Blood (Submitted).

Ataergin, S,; Arpaci, F.; Turan, M.; Solchaga, L.; Cetin, T.; Ozturk, M.; Ozet, A.; Komurcu, S.; Ozturk, B.: Reduced dose of lenograstim is as efficacious as standard dose of filgrastim for peripheral blood stem cell mobilization and transplantation: A randomized study in patients undergoing autologous peripheral stem cell transplantation. American Journal of Hematology 2008 (Epub ahead of print). Abstract

van Heeckeren, W.J.; Fanning, L.R.; Meyerson, M.; Fu, P.; Lazarus, H.M.; Cooper, B.; Gerson, S.L.; William, W.; Kendall-Keller, T.; Jaroscak, J.; Finney, M.; Fox, R.; Solchaga, L.A.; Kozik, M.; Creger, R.; and Laughlin, M.J.: The effect of HLA disparity and graft lymphocyte populations on engraftment rates and event-free survival in adult recipients of umbilical cord blood transplant: A prospective single institution study. British Journal of Hæmatology, 139(3):464-474 Abstract

Welter, J.F.; Solchaga, L.A.; and Penick, K.J.: Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. BioTechniques 2007, 42(6):732 – 737. Abstract

Solchaga, L.A.; Tognana, E.; Penick K.J.; Baskaran, H.; Kienitz, B.; Caplan, A.I.; Goldberg, V.G.; and Welter, J.F.: A rapid vacuum-seeding technique for the assembly of large tissue-engineered cell/scaffold composite. Tissue Engineering 2006, 12(7):1851-63. Abstract

Wenger, R.; Hans, M.G.; Welter, J.F.; Solchaga, L.A.; Sheu, Y.R.; and Malemud, C.J.: Tissue-engineered human cartilage constructs from human osteoarthritic chondrocytes. Frontiers in Bioscience 2006, 11:1690-1695. Abstract


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J. Michael Sorrell, Ph.D.

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology, (Submitted), 2009.

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A, Volume 15, Epub ahead of print, 2009. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations: differential interactions with vascular endothelial cells in co-culture. Non-soluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16:300-309. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult human dermis. Cell & Tissue Resarch 2007, 327:499-510. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A Self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract


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Jean F. Welter, M.D., M.Sc., Ph.D.

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications (submitted)

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Optimizing collagen-GAG scaffolds for tissue engineering applications using centrifugation. (in revision)

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Journal of Cell Physiology, 2009 (submitted).

Welter, J.F.; Solchaga, L.A.; and Penick, K.J.: Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. BioTechniques 2007, 42(6):732 – 737. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843 – 853. Abstract

Deglurkar, M.; Davy, D.T.; Goldberg, V.M.; Stewart, M.C.; and Welter, J.F.: Evaluation of machining methods for porous tantalum implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research (B) 2007, 80B(2):528 – 540. Abstract

Henderson, J.H.; Mansour, J.M.; Welter, J.F.; Awadallah, A.; Ginley, N.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering: comparison of chondrocytes from three anatomic locations in the rabbit. CWRU Orthopædic Journal 2006, 3(1):33- 42.

Solchaga, L.A.; Tognana, E.; Penick, K.; Baskaran, H.; Caplan, A.I.; Goldberg, V.G.; and Welter, J.F.: A rapid vacuum-seeding technique for the assembly of large tissue-engineered cell/scaffold composites. Tissue Engineering 2006, 12(7):1851 – 1863. Abstract

Wenger, R.; Hans, M.G.; Welter, J.F.; Solchaga, L.A.; Sheu, Y.R.; and Malemud, C.J.: Tissue-engineered human cartilage-constructs from human osteoarthritic chondrocytes. Frontiers in Biosciences 2006, 11:1690 – 1695. Abstract

Goldberg, V.M. and Welter, J.F.: Autografts. In: Callaghan, J.J.; Rosenberg, A.G.; and Rubash, H.E., eds.: The adult hip, Lippincott-Raven. 2006(23):304 - 328. Buy


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