Skeletal Research Center @ Case | Recent Faculty Publications

RECENT FACULTY PUBLICATIONS 2007-2013

Listed alphabetically by PI

Hülya Bükülmez	Arnold I. Caplan	David A. Carrino	Diego Correa
James E. Dennis	Victor M. Goldberg	Donald P. Lennon	J. Michael Sorrell
Jean F. Welter
		Figure from: “Chou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering, Part A 2013, 19(9-10):1081 - 1090.” Abstract Selected as cover art for "Tissue Engineering Part A - 2013".

Hülya Bükülmez, M.D.

Bükülmez, H.; Wargula, J.; Bove, K.; Lovell, D.; and Griffin, T.: High dose corticosteroids may aggravate the vasculopathy that underlies ulcerative juvenile dermatomyositis. Journal of Rheumatology. (In Press)

Matsushita, T.; Wilcox, W.R.; Chan, Y.Y.; Kawanami, A.; Bükülmez, H.; Balmes, G.; Krejci, P.; Mekikian, P.B.; Otani, K.; Yamaura, I.; Warman, M.L.; Givol, D.; and Murakami, S.: FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Human Molecular Genetics 2009 18(2):227-240. Abstract

Miles L, Bove KE, Lovell D, Wargula JC, Bükülmez, H., Shao, M.; Salisbury, S.; and Bean, J.A.: Predictability of the clinical course of juvenile dermatomyositis based on initial muscle biopsy: a retrospective study of 72 patients. Arthritis and Rheumatism 2007 Oct 15; 57(7):1183-91. Abstract

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Arnold I. Caplan, Ph.D.

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue Engineered Constructs for a Canine Critical Size Cranial Defect. Acta Biomaterialia, Submitted 2012.

Bonfield, T.L.; Lennon, D.; and Caplan, A.I.: Human mesenchymal stem cells resolve infection and inflammation in pseudomonas aeruginosa infected cystic fibrosis transmembrane receptor knockout mice. Am J Physiol Lung Cell Mol Physiol, Submitted 2012.

Crapnell, K.; Blaesius, R.; Hastings, A.; Eng, M.; Lennon, D.P.; Caplan, A.I.; and Bruder, A.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Submitted 2012.

Sorrell, J.M. and Caplan, A.I.: Mesenchymal stem cells in skin and in the role of mesenchymal stem cells in cutaneous wound repair. J Invest Dermatol, Submitted 2012.

Caplan AI.: Adult mesenchymal stem cells and the NO pathways. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2695-6. doi: 10.1073/pnas.1221406110. Epub 2013 Feb 8. No abstract available. Abstract

Caplan, A.: MSCs as Therapeutics. In: Stem Cell Biology and Regenerative Medicine. Mesenchymal Stromal Cells: Biology and Clinical Applications, Stem Cell Biology and Regenerative Medicine. Hematti, P. and Keating, A. (Eds.), Springer Science+Business Media New York, Chapter 5. Accepted 2012.

Caplan, A.I.: MSCs: The New Medicine (invited chapter) In: Stem Cells in Regenerative Medicine: Science, Regulation, and Business Strategies. A Vertes (Eds), John Wiley & Sons, Ltd, Accepted 2012.

Caplan, A.I.: Mesenchymal Stem Cells in Regenerative Medicine. In: Handbook of Stem Cells, Vol 2, eds A Atala and R Lanza, eds. Academic Press, Chapter 43, Pp. 493-502 , 2012.

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: Pericytes as the source of mesenchymal stem cells. In: Resident Stem Cells and Regenerative Therapy, Goldenberg, R.C. and de Carvalho, A.C.C., eds. Elsevier Inc. Chapter 12, Pp. 233-250, 2012.

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. Part A 2013, 19(9-10):1081 – 1090 Abstract

Dong, F. and Caplan, A.I.: Cell transplantation as an initiator of endogenous stem cell-based tissue repair. Curr Opin Organ Transplant. 2012, 17(6):670-4. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract

Lizier, N.F.; Kerkis, A.; Gomes, C.M.; Hebling, J.; Oliveira, C.F.; Caplan, A.I.; and Kerkis, I." Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One. 2012;7(6):e39885. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract

Carrino, D.A.; Mesiano, S.; Barker, N.M.; Hurd, W.W.; and Caplan, A.I.: Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J. 2012, 443(2):361-8. Abstract

Kerkis, I. and Caplan, A.I.: Stem cells in dental pulp of deciduous teeth. Tissue Eng Part B Rev. 2012, 18(2):129-38. Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. Eur J Dermatol. 2011, 21(3):359-70. Abstract

Singer, N.G. and Caplan, A.I.: Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011, 28;6:457-78. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.P.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol. 2010, 299(6):L760-70. Abstract

Caplan, A.I.: What's in a name? Tissue Eng Part A. 2010, 16(8):2415-7.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Acute asthma: An in vivo model for human mesenchymal stem cell efficacy. J. Immunol Methods. Submitted 2009.

Bonfield, T.L. and Caplan, A.I.: Adult mesenchymal stem cells: An innovative therapeutic for lung diseases. Discov Med. 2010, 9(47):337-45. Abstract

Abrahamsson, C.; Yang, F.; Park, H.; Brunger, J.; Valonen, P.; Langer, R.; Welter, J.; Caplan, A.; Guilak, F.; and Freed L.: Chondrogenesis and mineralization with in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds, Tissue Engineering Part A. 2010, 16(12):3709-18. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discovery Medicine, 9(46):236-42. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Diekman, B.O.; Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Tiss Eng, Part A, 523-533, 2010

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Influence of Adult Mesenchymal Stem Cells on In Vitro Vascular Formation. In: Advances in Tissue Engineering, Volume 1: Angiogenesis. Chapter 24, Pp. 241-248, 2010.

Caplan, A.I.: Mesenchymal stem cells: The past, the present, the future. Cartilage 1(1)6-9, 2010.

Caplan, A.I.: New era of cell-based orthopaedic therapies. Tissue Engineering, Part B, 15(2):195-200, 2009. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, Epub ahead of print 2009. Abstract

Caplan, A.I.: Why are MSCs therapeutic? New data: new insight. Journal of Pathology, 217:318-324, 2009. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A, Volume 15, Epub ahead of print, 2009. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15:313-318, 2009. Abstract

Park, H.; Guo, X.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Kasper, F.K.; and Mikos, A.G.: Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules, 10:541-546, 2009. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Raphael, R.M.; Jansen, J.A.; and Mikos, A.G.: Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of Biomedical Materials Research, Part A, 88(4):889-897, 2009. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research, 27(2):216-221, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology, (Submitted), 2009.

Butler, D.L; Lewis, J.F.; Frank, C.B; Banes, A.J.; Caplan, A.I.; de Deyne, P.G. et al.: Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: A conference report. Tissue Engineering, Part A 14(12): 2089-2104, 2008.

Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Caplan, A.I.: All MSCs are pericytes? Cell Stem Cell, 3(3):229-30, 2008. Abstract

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: The mesenchymal stem cell niche. 2007 (Submitted).

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26:2287-2299, 2008. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16(2):300-9. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract

Caplan, A.I.: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cell Physiology 2007, 213:341-347. Abstract

Gao, J.; Yao, J.Q.; and Caplan, A.I.: Stem cells for tissue engineering of articular cartilage. Proceedings of the Institute of Mechanical Engineers 2007, 221:441-450. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocyte from three anatomic locations in the rabbit. Tissue Engineering 2007, 13:843-853. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; and Mikos, A.G.: Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 2007, 28:3217-3227. Abstract

Kerkis, I.; Kerkis, A.; Dozortsev, D.; Stukart-Parsons, G.C.; Gomes-Massironi, S.M.; Pereira, L.V.; Caplan, A.I.; and Cerruti, H.F.: Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs 2006, 184(3-4):105-16. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.L.; and Miller, R.H.: Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult dermis. Cell and Tissue Research 2007, 327:499-510. Abstract

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David A. Carrino, Ph.D.

Engle, J.M.; Carrino, D.A.; Caplan, A.I.; and Apte, S.S.: Analysis of proteoglycans from human placenta. (In preparation).

Hattori, N.; Carrino, D.A.; Lauer, M.E.; Vasanji, A.; Wylie, J.D.; Nelson, C.M.; and Apte, S.S.: Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem. 2011, 286(39):34298-310. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related changes in the proteoglycans of human skin: versican and decorin. Glycobiology. 2011 21(2):257-68. Abstract

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Diego Correa, M.D., M.Sc., Ph.D.

Correa, D. and Segal, S.S.: Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation. 2012 May;19(4):306-15. doi: 10.1111/j.1549-8719.2012.00163.x. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal; 25(9): 3057-3067. Abstract

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010, 191(7):1271-1283. Abstract

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010, 19(4):533-546. Abstract

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010, 1192:32-37. Abstract

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James E. Dennis, Ph.D.

Liu, Y.; Goldberg, A.J.; Dennis, J.E.; Gronowicz, G.A.; and Kuhn, L.T.: One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating. PLoS One. 2012;7(3):e33225. Abstract

Kean, T.J.; Duesler, L.; Young, R.G.; Dadabayev, A.; Olenyik, A.; Penn, M.; Wagner, J. Fink, D.J.; Caplan, A.I.; and Dennis, J.E.: Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell. J Drug Target. 2012 20(1):23-32. Abstract

Bauer, J.; Liu, R.W.; Kean, T.J.; Dennis, J.E.; Petersilge, W.; and Gilmore, A.: A comparison of five treatment protocols for contaminated bone grafts in reference to sterility and cell viability. J Bone Joint Surg Am. 2011 93(5):439-44. Abstract

Song, I.H.and Dennis, J.E.: A novel method for large-scale immuno-SEM using protein G coupled polystyrene beads. J Electron Microsc (Tokyo). 2010;59(6):527-30. Abstract

Tu, Z.; Bu, H.; Dennis, J.E.; and Lin F.: Efficient osteoclast differentiation requires local complement activation. Blood. 2010 Nov 25;116(22):4456-63. doi: 10.1182/blood-2010-01-263590. Epub 2010 Aug 13. Abstract

Ko, I.K.; Kim, B.G.; Awadallah, A.; Mikulan, J.; Lin, P.; Letterio, J.J.; and Dennis, J.E.: Targeting improves MSC treatment of inflammatory bowel disease. Mol Ther. 2010 18(7):1365-72. Abstract

Gilpin, D.A.; Weidenbecher, M.S.; and Dennis, J.E.: Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstruction. Laryngoscope 2010 Mar;120(3):612-7 Abstract

Henderson, J.H.; Ginley, N.M.; Caplan, A.I.; Niyibizi, C.; and Dennis, J.E.: Low Oxygen Tension During Incubation Periods of Chondrocyte Expansion Is Sufficient to Enhance Postexpansion Chondrogenesis. Tissue Eng Part A. 2010 May;16(5):1585-93 Abstract

Weidenbecher, M.; Tucker, H.M.; Gilpin, D.A.; and Dennis, J.E.: Tissue-engineered trachea for airway reconstruction. Laryngoscope 2009, 119(11):2118-23. Abstract

Wagner, J.; Kean, T.; Young, R.; Dennis, J.E.; and Caplan, A.I.: Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol 2009 20(5):531-6. Abstract

van Osch, G.J.; Brittberg, M.; Dennis, J.E.; Bastiaansen-Jenniskens, Y.M.; Erben, R.G.; Konttinen, Y.T.; and Luyten, F.P.: Cartilage repair: past and future--lessons for regenerative medicine. J Cell Mol Med 2009, 13(5):792-810. Abstract

Ko, I.K.; Kean, T.J.; and Dennis, J.E.: Targeting mesenchymal stem cells to activated endothelial cells. Biomaterials 2009, 30(22):3702-10. Abstract

Song I.H.; Caplan A.I.; and Dennis, J.E.: In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. Journal of Orthopedic Research 2009, 27(7):916-21. Abstract

Wang, F.; Dennis, J.E.; Awadallah, A.; Solchaga, L.A.; Molter, J.; Kuang, Y.; Salem, N.; Lin, Y.; Tian, H.; Kolthammer, J.A.; Kim, Y.; Love, Z.B.; Gerson, S.L.; and Lee, Z.: Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiol Genomics 2009, 7(1):23-34. Abstract

Moioli E.K.; Clark P.A.; Chen M.; Dennis J.E.; Erickson H.P.; Gerson S.L.; and Mao J.J.: Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. PLoS One 2008, 3(12):e3922. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research 2009, 27(2):216-221. Abstract

Lee, Z.; Dennis, J.E.; and Gerson, S.L.: Imaging stem cell implant for cellular-based therapies. Experimental Biology & Medicine 2008 (Epub ahead of print). Abstract

Weidenbecher, M.; Tucker, H.M.; Awadallah, A.; and Dennis, J.E.: Fabrication of a neotrachea using engineered cartilage. Laryngoscope 2008, 118(4):593-8. Abstract

Dennis, J.E.; Esterly, K.; Awadallah, A.; Parrish, C.R.; Poynter, G.M.; and Goltry, K.L.: Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration. Stem Cells 2007, 25(10):2575-82. Abstract

Chen, X.; Song, I.H.; Dennis, J.E.; and Greenfield, E.M.: Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts. Journal of Bone & Minereral Research 2007, 22(5):656-64. Abstract

Love, Z.; Wang, F.; Dennis, J.; Awadallah, A.; Salem, N.; Lin, Y.; Weisenberger, A.; Majewski, S.; Gerson, S.; and Lee, Z.: Imaging of mesenchymal stem cell transplant by bioluminescence and PET. Journal of Nuclear Medicine 2007, 48:2011-2020. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843-53. Abstract

Weidenbecher, M.; Henderson, J.H.; Tucker, H.M.; Baskin, J.Z.; Awadallah, A.; and Dennis, J.E.: Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction. Laryngoscope 2007, 117(10):1745-9. Abstract

Caplan, A.I. and Dennis, J.E.: Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 2006, 98:1076-1084. Abstract

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Victor M. Goldberg, M.D.

Bonsignore, L.A.; Anderson, J.R.; Lee, Z.; Goldberg, V.M.; and Greenfield, E.M.: Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation. Bone. 2013, 52(1):93-101. Abstract

Bawa, H.S.; Wera, G.D.; Kraay, M.J.; Marcus, R.E.; and Goldberg, V.M.: Predictors of Range of Motion in Patients Undergoing Manipulation After TKA. Clin Orthop Relat Res. 2013, 471(1):258-63. Abstract

French, K.; Moore, R.; Gawel, H.; Kurtz, S.M.; Kraay, M.J.; Xie, K.; Goldberg, V.M.; and Rimnac, C.M.: Retrieval analysis of Harris-Galante I and II acetabular liners in situ for more than 10 years. Acta Orthop. 2012, 83(4):366-73. Abstract

Bonsignore, L.A.; Colbrunn, R.W.; Tatro, J.M.; Messerschmitt, P.J.; Hernandez, C.J.; Goldberg, V.M.; Stewart, M.C.; and Greenfield, E.M.: Surface contaminants inhibit osseointegration in a novel murine model. Bone. 2011, 49(5):923-30. Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Medel, F.J.; Kurtz, S.M.; Sharkey, P.F.; Austin, M.S.; Klein, G.R.; Cohen, A.R.; Patel, H.; Goldberg, V.M.; Kraay, M.J.; and Rimnac, C.M.: Post damage in contemporary posterior-stabilized tibial inserts: influence of implant design and clinical relevance. J Arthroplasty. 2011, 26(4):606-14. Abstract

Goldberg, V.M.; Buckwalter, J.; Halpin, M.; Jiranek, W.; Mihalko, W.; Pinzur, M.; Rohan, B.; Vail, T.; Walker, P.; Windsor, R.; and Wright, T: Recommendations of the OARSI FDA Osteoarthritis Devices Working Group. Osteoarthritis Cartilage. 2011 19(5):509-14 Abstract

Fitzgerald, S.J.; McAndrew, C.M.; Kraay, M.J.; and Goldberg, V.M.: Incidence of postthrombotic syndrome in patients undergoing primary total hip arthroplasty for osteoarthritis. Clin Orthop Relat Res. 2011 469(2):530-4. Abstract

Greenfield, E.M.; Beidelschies, M.A.; Tatro, J.M.; Goldberg, V.M.; and Hise, A.G.: Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010 285(42):32378-84 Abstract

Wera, G.D.; Gillespie, R.J.; Petty, C.; Petersilge, W.J.; Kraay, M.J.; and Goldberg, V.M.: Revision of hip resurfacing arthroplasty. Am J Orthop (Belle Mead NJ). 2010 39(8):E78-83. Abstract

Furmanski, J. and Goldberg, V.M.: Commentary on an article by B.H. Currier, MChE, et al.: "In vivo oxidation in remelted highly cross-linked retrievals". J Bone Joint Surg Am. 2010 92(14):e23. Abstract

Goldberg, V.M. and Goldberg, L.: Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis. J Pain Res. 2010, 3:51-56. Abstract

Furmanski, J. and Goldberg, V,M.: Commentary on an article by B.H. Currier, MChE, et al.: "In vivo oxidation in remelted highly cross-linked retrievals". J Bone Joint Surg Am. 2010, 92(14):e23.

Wera, G.D.; Gillespie, R.J.; Petty, C.; Petersilge, W.J.; Kraay, M.J.; and Goldberg, V.M.: Revision of hip resurfacing arthroplasty. Am J Orthop (Belle Mead NJ). 2010, 39(8):E78-83. Abstract

Greenfield, E.M.; Beidelschies, M.A.; Tatro, J.M.; Goldberg, V.M.; and Hise A.G.: Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010, 285(42):32378-84. Abstract

Marulanda, G.A.; Krebs, V.E.; Bierbaum, B.E.; Goldberg, V.M.; Ries, M.; Ulrich, S.D.; Seyler, T.M.; and Mont, M.A.: Hemostasis using a bipolar sealer in primary unilateral total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2009, 38(12):E179-83. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated Resurfacing of the Previously Unresurfaced Patella Total Knee Arthroplasty. Journal of Arthroplasty 2010, 25(5):754-8. Abstract

Hartzband, M.A.; Glassman, A.H.; Goldberg, V.M.; Jordan, L.R.; Crowninshield, R.D.; Fricka, K.B.; and Jordan, L.C.: Survivorship of a Low-stiffness Extensively Porous-coated Femoral Stem at 10 Years. Clin Orthopædics and Related Research 2010, 468(2):433-40. Abstract

McAndrew, C.M.; Fitzgerald, S.J.; Kraay, M.J.; and Goldberg V.M.: Incidence of Postthrombotic Syndrome in Patients Undergoing Primary Total Knee Arthroplasty for Osteoarthritis. Clin Orthopædics and Related Research 2010, 468(1):178-81. Abstract

Garcia, R.M.; Kraay, M.J.; Messerschmitt, P.J.; Goldberg, V.M.; and Rimnac, C.M.: Analysis of retrieved ultra-high-molecular-weight polyethylene tibial components from rotating-platform total knee arthroplasty. Journal of Arthroplasty 2009, 24(1):131-8. Abstract

Garcia, R.M.; Kraay, M.J.; Conroy-Smith, P.A.; and Goldberg, V.M.: Management of the deficient patella in revision total knee arthroplasty. Clin Orthopædics and Related Research 2008, 466(11):2790-7. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Isolated all-polyethylene patellar revisions for metal-backed patellar failure. Clin Orthopædics and Related Research 2008, 466(11):2784-9. Abstract

Beidelschies, M.A.; Huang, H.; McMullen, M.R.; Smith, M.V.; Islam, A.S.; Goldberg, V.M.; Chen, X.; Nagy, L.E.; and Greenfield, E.M.: Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. Journal of Cell Physiology 2008 217(3):652-66. Abstract

Garcia, R.M.; Kraay, M.J.; and Goldberg, V.M.: Retention of superficially damaged femoral components after metal-backed patella component failure. Journal of Arthroplasty 2008, 23(6):850-8. Abstract

Goldberg, V.M.: Contemporary total joint arthroplasty. North Carolina Medical Journal 2007, 68(6):447-50. Abstract

Mont, M.A.; Seyler, T.M.; Ulrich, S.D.; Beaule, P.E.; Boyd, H.S.; Grecula, M.J.; Goldberg, V.M.; Kennedy, W.R.; Marker, D.R.; Schmalzried, T.P.; Sparling, E.A.; Vail, T.P.; and Amstutz, H.C.: Effect of changing indications and techniques on total hip resurfacing. Clinical Orthopædics & Related Research 2007, 465:63-70. Abstract

Akhavan, S. and Goldberg, V.M.: Clinical outcome of a fibermetal taper stem: minimum 5-year followup. Clinical Orthopædics & Related Research 2007, 465:106-11. Abstract

Taki, N.; Tatro, J.M.; Lowe, R.; Goldberg, V.M.; and Greenfield, E.M.: Comparison of the roles of IL-1, IL-6, and TNF-α in cell culture and murine models of aseptic loosening. Bone 2007, 40:1276-1283. Abstract

Smith, M.V.; Lee, M.J.; Islam, A.S.; Rohrer, J.L.; Goldberg, V.M.; Beidelschies, M.A.; and Greenfield, E.M.: Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-α production in response to titanium particles in vitro. Journal of Bone & Joint Surgery Am 2007, 89:1019-1027. Abstract

Tatro, J.M.; Taki, N.; Islam, A.S.; Goldberg, V.M.; Rimnac, C.M.; Doerschuk C.M.; Stewart, M.C.; and Greenfield, E.M.: The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Journal of Orthopædic Research 2007, 25:361-369. Abstract

Deglurkar, M.; Davy, D.T.; Stewart, M.; Goldberg, V.M.; and Welter, J.F.: Evaluation of machining methods for trabecular metal implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research Part B - Applied Biomaterials 2007,80:528-540. Abstract

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Donald P. Lennon, D.D.S.

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010, 9(46):236-42. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.P.; and Miller, R.: Mesenchymal stem cell signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

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J. Michael Sorrell, Ph.D.

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology 2009, 276:161-214. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A 2009, 15(7):1751-61. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations: differential interactions with vascular endothelial cells in co-culture. Non-soluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16:300-309. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult human dermis. Cell & Tissue Resarch 2007, 327:499-510. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A Self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract

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Jean F. Welter, M.D., M.Sc., Ph.D.

Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring shell thickness in engineered cartilage. (in revision)

Penick, K.J.; Solchaga, L.A.; Caplan A.I.; Goldberg, V.M.; and Welter, J.F.: Epitope retrieval for type X collagen detection. (in revision)

Welter, J.F.; Penick, J.; Solchaga, L.A.: Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique Stem Cells International 2013:806525 Abstract

Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013, 33(1): 1-16 doi:10.5405/ jmbe.1254

Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol. 2012;506:247-63. Abstract

Shao, Y.Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50(1):79-84. [Epub ahead of print] Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346-59 Abstract

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications. Methods in Molecular Biology. Humana Press, 2011:698:253-278. Abstract)

Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract

Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Optimizing collagen-GAG scaffolds for tissue engineering applications using centrifugation. Journal of Biomedical Materials Research (A) Journal of Biomedical Materials Research, Part A 2010 94(4):1050 – 1060. Abstract

Welter, J.F.; Solchaga, L.A.; and Penick, K.J.: Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. BioTechniques 2007, 42(6):732 – 737. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843 – 853. Abstract

Deglurkar, M.; Davy, D.T.; Goldberg, V.M.; Stewart, M.C.; and Welter, J.F.: Evaluation of machining methods for porous tantalum implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research (B) 2007, 80B(2):528 – 540. Abstract

Henderson, J.H.; Mansour, J.M.; Welter, J.F.; Awadallah, A.; Ginley, N.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering: comparison of chondrocytes from three anatomic locations in the rabbit. CWRU Orthopædic Journal 2006, 3(1):33- 42.

Solchaga, L.A.; Tognana, E.; Penick, K.; Baskaran, H.; Caplan, A.I.; Goldberg, V.G.; and Welter, J.F.: A rapid vacuum-seeding technique for the assembly of large tissue-engineered cell/scaffold composites. Tissue Engineering 2006, 12(7):1851 – 1863. Abstract

Wenger, R.; Hans, M.G.; Welter, J.F.; Solchaga, L.A.; Sheu, Y.R.; and Malemud, C.J.: Tissue-engineered human cartilage-constructs from human osteoarthritic chondrocytes. Frontiers in Biosciences 2006, 11:1690 – 1695. Abstract

Goldberg, V.M. and Welter, J.F.: Autografts. In: Callaghan, J.J.; Rosenberg, A.G.; and Rubash, H.E., eds.: The adult hip, Lippincott-Raven. 2006(23):304 - 328. Buy

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SKELETAL RESEARCHCENTER

RECENT FACULTY PUBLICATIONS 2007-2013

Listed alphabetically by PI

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