DONALD P. LENNON
SENIOR RESEARCH ASSOCIATE

Don Lennon

EDUCATION

INSTITUTION AND LOCATION DEGREE YEAR
CONFERRED
FIELD OF STUDY
John Carroll University, Cleveland, Ohio
Case Western Reserve University
B.S.
DD.S.
1963
1971
Sociology, Dentistry

EMPLOYMENT HISTORY

1963-1965 U.S. Army, Fort Wainwright, Alaska, Motor Officer, Transportation Motor Pool.

1965-1967 Summit County Juvenile Court, Akron, Ohio, Probation Officer.

1971-1972 Highland View Hospital, Cleveland, Ohio, Dental Internship.

1972-1973 Private Dental Practice, Cleveland, Ohio, Associate (of) Drs. Rosewater, D.D.S. and Sperber, D.D.S.

1973-1979 Private Dental Practice, Cleveland, Ohio, Associate (with) Richard J. Stanco, D.D.S.

1979-Pres Case Western Reserve University, Cleveland, Ohio, Dept of Biology

1979-1988 Research Assistant; Laboratory of Dr. Arnold I. Caplan.

1985-1988 Instructor, Human Anatomy.

1988-Pres Senior Research Associate; Laboratory of Dr. Arnold I. Caplan;
Director, Cell Culture, Skeletal Research Center

PUBLICATIONS

  1. Lennon, D.P., Osdoby, P., Carrino, D.A., Vertel, B.M. and Caplan, A.I. (1983): "Isolation and Characterization of Chondrocytes and Non-Chondrocytes From High-Density Chick Limb Bud Cultures. " Journal of Craniofacial Genetics and Developmental Biology. 3:235-251.
  2. Carrino, D.A., Lennon, D.P. and Caplan, A.I. (1983): "Extracellular Matrix and the Maintenance of the Differentiated State: Proteoglycans Synthesized by Replated Chondrocytes and Non-Chondrocytes. " Developmental Biology 99:132-144.
  3. Kujawa, M.J., Lennon, D.P. and Caplan, A.I. (1989): "Growth and Differentiation of Stage 24 Limb Mesenchymal Cells in a Serum-Free Chemically Defined Medium. " Experimental Cell Research 183:45-61.
  4. Carrino, D.A., Kujawa, M.J., Lennon, D.P. and Caplan, A.I. (1989): "Altered Cartilage Proteoglycans Synthesized by Chick Limb Bud Chondrocytes Cultured in Serum-Free Defined Medium. " Experimental Cell Research 183:62-71.
  5. Nakahara, H., Dennis, J.D., Bruder, S.B., Haynesworth, S.E., Lennon, D.P. and Caplan, A.I. (1991): "In Vitro Differentiation of Bone and Hypertrophic Cartilage From Periosteal-Derived Cells. " Experimental Cell Research 195:492-503.
  6. Lennon, D.P., Carrino, D.A., Baber, M.A. and Caplan, A.I. (1991): "Generation of a Monoclonal Antibody Against Avian Small Dermatan Sulfate Proteoglycans: Immunolocalization and Tissue Distribution of PG-II (Decorin) in Embryonic Tissues. " Matrix 11:412-427.
  7. Lennon, D.P., Haynesworth, S.E., Young, R.G., Dennis, J.E. and Caplan, A.I. (1995): "A Chemically Defined Medium Supports Proliferation and Maintains Osteochondrogenic Potential of Rat Marrow-Derived Mesenchymal Stem Cells, " Experimental Cell Research 219:211-222.
  8. Saito, T., Dennis, J.E., Lennon, D.P., Young, R.G. and Caplan, A.I. (1996): "Evidence for Fusion and Dystrophin Expression of Mesenchymal Stem Cells Within Myotubes of mdx Mice In Vitro and In Vivo, " Tissue Engineering 1:327-344.
  9. Lennon, D.P., Bruder, S.P., Haynesworth, S.E., Jaiswal, N., and Caplan, A.I. (1996): Human and Animal Mesenchymal Progenitor Cells From Bone Marrow: Selection of Serum for Optimal Proliferation. " In Vitro Cell and Developmental Biology 32:602-611.
  10. Mann, L.M., Lennon, D.P., and Caplan, A.I. (1996): "Cultured Rat Pulp Cells have the Potential to form Bone, Cartliage, and Dentin In Vivo Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Edited by Z. Davidovittch and L.A. Norton, pages 7-16, Harvard Society for the Advancement of Orthdontics, Boston, MA.
  11. Boyan, B.D., Caplan, A.I., Heckman, J.D., Lennon, D.P., Ehler, W., and Schwartz, Z. (1999): " Osteochondral Progenitor Cells in Acute and Chronic Canine Nonunions." Journal of Orthopædic Research 17(2): 246-255.
  12. Nakamura, O., Fink, D.J., Lennon, D.P., Laraia, V.L., Heuer, A.H., and Caplan, A.I. (1999): "Matrix-Directed In Vitro Osteogenesis. " Bioceramics vol 12, p 249-252, eds H. Ohgushi, G.W. Hastings and T. Yoshikawa (Proceedings of the 12th Intl Symposium on Ceramics in Medicine) Nara, Japan 1999; World Scientific Publishing Pte Ltd.
  13. Lennon, D.P., Haynesworth, S.E., Arm, D., Baber, M.A. and Caplan A.I. (2000): "Dilution of Human Mesenchymal Stem Cells Dermal Fibroblasts and the Effects on In Vitro and In Vivo Osteogenesis." Developmental Dynamics 219:50-62.
  14. Lennon, D.P., Edmison, J., and Caplan, A. I. (2000):"Cultivation of Rat Marrow-Derived Mesenchymal Stem Cells in Reduced Oxygen Tension: Effects on In Vitro and In Vivo Osteochondrogenesis. Journal of Cellular Physiology 187:345-355.
  15. Tallheden, T., Dennis, J.E., Lennon, D.P., Sjögren-Jansson, E., and Caplan, A.I. (2003): "Heterogeneity in Multipotency of Human Articular Chondrocytes.” Journal of Bone & Joint Surgery 85-A Suppl 2:93-100.
  16. Yamashita, K., Dennis, J.E., Lennon, D.P., Morimoto, H., Kitamura, S., and Caplan, A.I. (2003): "Dental Pulp Cells with Multi-Potential for Differentiation to Odontoblast and Chondroblast” Journal of Hard Tissue Biology 12[21] (2003):49-55.
  17. Solchaga, L.A., Welter, J.F., Lennon, D.P., and Caplan, A.I. (2004): "Generation of Pleuripotent Stem Cells and their Differentiation to the Chondrocytic Phenotype” In: Osteoarthritis: Methods in Molecular Medicine, vol. 100: Cartilage and Osteoarthritis, vol 1: 53-67, edited by M. Sabiatini, P. Pastoureau, and F. De Ceuninck, Humana Press, Totawa, NJ.
  18. Alhadlaq, A., Elisseeff, J., Hong, L., Williams, C., Caplan A.I., Sharma, B., Kopher, R., Tomkoria, S., Lennon, D.P., Lopez, A., Mao, J. (2004): "Adult stem cell driven genesis of human-shaped articular condyle” Annals of Biomedical Engineering 32:911-923.
  19. Dean, D., Wolfe, M.S., Ahmad,Y., Totonchi, A., Chen, J. E-K., Fisher, J.P., Cooke, M.N., Rimnac, C.M., Lennon, D.P., Caplan, A.I., Topham, N.S., Mikos, A.G. (2005): "Effect of Transforming Growth Factor b-2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits”, Tissue Engineering 11[5/6]: 923-939.
  20. Lennon, D.P. and Caplan, A.I. (2006): "Mesenchymal Stem Cells for Tissue Engineering” In: Culture of Cells for Tissue Engineering, edited by I. Freshney and G. Vunjak-Novakovic, John Wiley and Sons, Hoboken, NJ.
  21. Lennon, D.P. and Caplan, A.I. (2006): "Isolation of Human Marrow-derived Mesenchymal Stem Cells”, Experimental Hematology, 34:1604-1605.
  22. Lennon, D.P. and Caplan, A.I. (2006): "Isolation of Rat Marrow-derived Mesenchymal Stem Cells”, Experimental Hematology, 34:1606-1607.
  23. Bai, L., Caplan, A.I., Lennon, D.P., Miller, R. (2007): "Mesenchymal Stem Cell Signals Regulate Neural Stem Cell Fate”. Neurochemical Research, 32:353-362
  24. Grayson, W.L., Brumirantana, S., Canizzarro, C., Chao, P.G., Lennon, D.P., Caplan, A.I., and Vunjak-Novakovic, G. (2008): "Effects of Initial Seeding Density and Fluid Perfusion Rate on Formation of Tissue-Engineered Bone”, Tissue Engineering (In Press).
  25. da Silva Meirelles L., Sand T.T., Harman R.J., Lennon D.P., and Caplan A.I. (2009): "MSC frequency correlates with blood vessel density in equine adipose tissue." Tissue Eng Part A.: 15(2):221-9.PMID: 18847356
  26. Bai L., Lennon D.P., Eaton V., Maier K., Caplan A.I., Miller S.D., and Miller R.H. (2009): "Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis." Glia 57 (11):1192-203.PMID: 19191336
  27. Diekman B.O., Rowland C.R., Caplan A.I., Lennon D., and Guilak F. (2009): "Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix." Tissue Eng Part A. [Epub ahead of print] PMID: 19715387