VICTOR M. GOLDBERG
PROFESSOR

 Victor Goldberg

EDUCATION/TRAINING

INSTITUTION AND LOCATION
DEGREE
YEAR(s)
FIELD OF STUDY
New York University, NY
State University of New York, Downstate, NY
University Hospitals of Cleveland
Hospital for Special Surgery, NY
Clinic Research center, Harrow, Middlesex, Engl. 		B.A.
M.D.
Intern./Resid.
Residency
Fellowship		 1960
1964
1964-66
1968-1971
1971-1972 		Science
Medicine
Surgery
Orthopædics
Immunol. of transplant.

Professional Experience

1973-present Consultant, Orthopædic Surgery, Veterans Administration Hospital, Cleveland, Ohio

1974-1989 Chairman, Residency Selection and Review Committee, Department of Orthopædics, Case Western Reserve University, School of Medicine, Cleveland, Ohio

1974-1979 Assistant Professor of Orthopædics, CWRU School of Medicine, Cleveland, Ohio

1979-1983 Associate Professor of Orthopaedics, CWRU School of Medicine, Cleveland, Ohio

1987-1988 President, Orthopaedic Research Society

1983-1989 Professor and Vice-Chairman, Department of Orthopædics, CWRU, Cleveland, Ohio

1989-2003 Professor and Chairman, Department of Orthopædics, CWRU, Cleveland, Ohio

1996-1997 President, Knee Society

2003-present Professor, Department of Orthopædics, CWRU, Cleveland, Ohio

Research

1971-1972 Fellow, Immunology of transplantation (with Drs. E. Lance and P.B. Medawar)

1972-1993 Associate Investigator, Pathogenesis of Experimental Osteoarthritis and Rheumatoid Arthritis (with Dr. R. Moskowitz)

1978-1989 Principal Investigator, Bone Allotransplantation

1981-1985 Member, NIH Study Section, Musculoskeletal Section

1982-1993 Principal Investigator, Structure and Metabolism of Vascularized Allografts

1985 Kappa Delta Award, Excellence in Research in Orthopaedic Surgery

1986-present Principal Investigator, Controlled Cartilage Repair

1987-1988 Peer Review, Orthopaedic Research and Education Foundation

1988-1991 Member, National Arthritis Advisory Board, National Institutes of Health

1992-1996 Principal Investigator, Degeneration and Repair of Cartilage (Program Project)

1992 Kappa Delta Award, Excellence in Research in Orthopaedic Surgery

1994-1997 Member, NIH Study Section - Research training and Career Awards

1997-present Member, Advisory Council to NIAMS

Research Projects Ongoing or Completed During the Last 3 Years

"Controlled Cartilage Repair"
Principal Investigator: Victor M. Goldberg, MD
Agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Type: R01 (AR37726, years 10-13). Period: March 1, 1996 to November 30, 1999
The major goal of this project is to study the role of articular cartilage chondrocytes and mesenchymal stem cells in articular cartilage repair.

Bioactive Factors in Skeletal Repair
Principal Investigator: Arnold I. Caplan, Ph.D.
Agency: National Institutes of Health
Type: R01 (DE07220) Period: 07/01/98-05/31/03
The major goals of this project are (1) to study the factors involved in engineered fracture repair; to determine the contribution of these stem cells to the repair process and its effects on stem cells and the population of cells from the three distinct stages of the osteogenic lineage; (2) to test several predictions related to the control of engineered fracture repair at one well-defined site.

Cellular Mechanisms of Implant Loosening
Principal Investigator: Edward Greenfield, Ph.D.
Agency: National Institutes of Health
Type: R01 (AR43769-02) Period: 09/27/96-08/31/00
The major goals of this project are to (1) determine whether orthopaedic wear debris stimulates osteoclast differentiation or osteoclast activation, (2) identify properties of orthopaedic wear debris that are important in the stimulation of bone resorption, (3) identify cytokines that are functionally important in stimulation of bone resorption by orthopaedic wear debris, and (4) identfy cell types that are functionally important in stimulation of bone resorption by orthopaedic wear debris.

Northeast Ohio Multipurpose Arthritis and Musculoskeletal Diseases center
Principal Investigator: Roland Moskowtiz, M.D.
Agency: National Institutes of Health
Type: (AR2018) Period: 07/01/98-06/03/02
A comprehensive center for funding of research and demonstration projects in basic science, musculoskeletal disease, and health services/education/epidemiology research.

Prospective Clinical Research Grant
Principal Investigator: Kraay
Agency: OREF Period: 07/01/99-06/30/02
Prospective Randomized Study of Zirconia Ceramic versus Co-Cr-Mo Alloy Femoral Heads with Respect to Wear of Polyethylene Acetabular Cups in THR
The major goal of this research is to establish the rates of wear and the incidence of osteolysis in THA using zirconia and conventional metal alloy femoral components and to determine if there is a clinically significant difference in polyethylene wear.

Representative Publications

  1. Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg VM: Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg 76A:579-592, 1994.
  2. Goldberg VM, Caplan AI: Biological resurfacing: an alternative to total joint arthroplasty. Orthopedics 17:819-821, 1994.
  3. Khoury MA, Goldberg VM, Stevenson S: Demonstration of HLA and ABH antigens in fresh and frozen human menisci by immunohistochemistry. J Orthop Res 12:751-757, 1994.
  4. Dean JC, Tisdel CL, Goldberg VM, Parr J, Davy D, Stevenson S: Effects of hydroxyapatite tricalcium phosphate coating and intracancellous placement on bone ingrowth in titanium fibermetal implants. J Arthroplasty 10:830-838, 1995.
  5. Kotzar GM, Davy DT, Berilla J, Goldberg VM: Torsional loads in the early postoperative period following total hip replacement. J Orthop Res 13:945-955, 1995.
  6. Kraay MJ, Goldberg VM, Brown SA, Merritt K: Retrieval analysis of Ti-6Al-4V Miller-Galante total knee replacements. In: Medical Applications of Titanium and Its Alloys: The Material and Biological Issues, ASTM STP 1272. Brown SA, Lemons JE (eds), American Society for Testing and Materials, 1996.
  7. Stevenson S, Emery SE, Goldberg VM: Factors affecting bone graft incorporation. Clin Orthop 323:66-74, 1996.
  8. Stevenson S, Shaffer JW, Goldberg VM: The humoral response to vascular and nonvascular allografts of bone. Clin Orthop 326:86-95, 1996.
  9. Stevenson S, Goldberg VM, Tisdel CL, Dean JC, Parr JE, Davy DT: Application of hydroxyapatite in total knee arthroplasty. Current Concepts in Primary and Revision Total Knee Arthroplasty, Eds: Insall JN, Scott WN, Scuderi GR. Lippincott-Raven Publishers, pp. 99-113, 1996.
  10. Goldberg VM, Ninomiya J, Kelly G, Kraay M: Hybrid total hip arthroplasty: a 7- to 11-year followup. Clin Orthop 333:147-154, 1996.
  11. Singerman R, Pagan HD, Peyser AB, Goldberg VM: Effect of femoral component rotation and patellar design on patellar forces. Clin Orthop 334:345-353, 1997.
  12. Stevenson S, Li XQ, Davy DT, Klein L, Goldberg VM: Critical biological determinants of incorporation of non-vascularized cortical bone grafts. J Bone Joint Surg 79-A:1-16, 1997.
  13. Goldberg VM: Biologic restoration of articular cartilage. Ryumachi 37:148, 1997.
  14. Goldberg VM, Buckwalter JA, Hayes WC, Koval KJ: Orthopaedic challenges in an aging population. Instr. Course Lect 46:417-422, 1997.
  15. Greenfield E, Goldberg V: The genetic determination of bone mass. Lancet 350:1263-1264, 1997.
  16. Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM: Overview: Principles of cartilage repair and regeneration. Clin Orthop 342:254-269, 1997.
  17. Ragab AA, Lavish SA, Banks MA, Goldberg VM, Greenfield AM: Osteoclast differentiation requires ascorbic acid. J Bone Miner Res 13:970-977, 1998.
  18. Jinno T, Goldberg VM, Davy D, Stevenson S: Osseointegration of surface-blasted implants made of titanium alloy and cobalt-chromium alloy in a rabbit intramedullary model. J Biomed Mater Res 42:20-29, 1998.
  19. Goldberg VM, Solchaga L, Yoo J, Johnstone B, Caplan AI: Chondroprogenitor cell repair of full thickness defects of articular cartilage. J Sports traumatol 20:81-89, 1998.
  20. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238:265-272, 1998.
  21. Bruder SP, Kraus KH, Goldberg VM, Kadilaya S: The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg 80:985-986, 1998.
  22. Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan A, Goldberg VM, Johnstone B: The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg 80A:1745-1757, 1998.
  23. Wakitani S, Goto T, Young RG, Mansour JM, Goldberg VM, Caplan AI: Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. Tissue Eng 4:429-444, 1998.
  24. Goldberg VM, Solchaga LA, Lundberg M, Yoo J, Johnstone B, Huibregtse BA, Caplan A: Regenerative cell-based repair of osteochondral defects of articular cartilage. Semin Arthroplasty 10:30-36, 1999.
  25. Hanada K, Solchaga LA, Caplan AI, Hering TM, Goldberg VM, Yoo JU, Johnstone B: Chondrogenic induction of rat periosteum-derived cells by bone morphogenetic protein-2 (BMP-2) and modulation by transforming growth factor b 1 (TGF-b 1), submitted to Exp Cell Res, 1999.
  26. Goldberg VM, Caplan AI: Biologic restoration of articular surfaces. Instr Course Lect 48:623-628, 1999.
  27. Ragab AA, Kraay MJ, Goldberg VM: Clinical and radiographic outcomes of total hip arthroplasty with insertion of an anatomically designed femoral component without cement for the treatment of primary osteoarthritis. A study with a minimum of six years of follow-up. J Bone Joint Surg 81:210-218, 1999.
  28. Ninomiya JT, Bi Y, Banks MA, Lavish SA, Goldberg VM, Greenfield EM: Bone marrow cells produce soluble factors that inhibit osteoclast activity. J Orthop Res 17:51-58, 1999.
  29. Bukulmez H, Matthews A, Sullivan C, Chen C, Kraay M, Elston R, Moskowitz R, Goldberg V, Warman M: Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families. Arthritis Res Ther 8:R25, 2006.
  30. Solchaga LA, Tognana E, Penick K, Baskaran H, Goldberg VM, Caplan AI, Welter JF: A rapid seeding technique for the assembly of large cell/scaffold composite constructs. Tissue Eng 12:1851-1863, 2006.
  31. Nalepka JL, Lee MJ, Kraay MJ, Marcus RE, Goldberg VM, Chen X, Greenfield EM: lipopolysaccharide found in aseptic loosening of patients with inflammatory arthritis. Clin Orthop Relat Res 451:229-235, 2006.
  32. Akhavan S, Matthiesen MM, Schulte L, Penoyar T, Kraay MJ, Rimnac CM, Goldberg VM: Clinical and histologic results related to a low-modulus composite total hip replacement stem. J Bone Joint Surg Am 88:1308-1314, 2006.
  33. Chang Y, Goldberg VM, Caplan AI.: Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells. Clin Orthop Relat Res 452: 242-249, 2006.
  34. Kraay MJ, Thomas RD, Rimnac CM, Fitzgerald SJ, Goldberg VM: Zirconia versus Co-Cr femoral heads in total hip arthroplasty: early assessment of wear. Clin Orthop Relat Res 453:86-90, 2006.
  35. Kurtz SM, Hozack WJ, Purtill JJ, Marcolongo M, Kraay MJ, Goldberg VM, Sharkey PF, Parvizi J, Rimnac CM, Edidin AA: 2006 OTTO AUFRANC AWARD PAPER: Significance of in vivo degradation for polyethylene in total hip arthroplasty. Clinical Orthop Relat Res 453:47-57, 2006.
  36. Deglurkar, M., Davy, D.T., Stewart, M., Goldberg, V.M., and Welter, J.F.: Evaluation of machining methods for trabecular metal implants in a rabbit intramedullary osseointegration model. J Biomed Mater Res B Appl Biomater 80:528-540, 2007.
  37. Tatro JM, Taki N, Islam AS, Goldberg VM, Rimnac CM, Doerschuk CM, Stewart MC, Greenfield EM: The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. J Orthop Res 25:361-369, 2007.
  38. Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM: Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-α production in response to titanium particles in vitro. J Bone Joint Surg Am 89:1019-1027, 2007.
  39. Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM: Comparison of the roles of IL-1, IL-6, and TNFα in cell culture and murine models of aseptic loosening. Bone, 40:1276-1283, 2007.
  40. Kraay MJ, Thomas RD, Rimnac CM, Fitzgerald SJ, Goldberg VM: Zirconia versus Co-Cr femoral heads in total hip arthroplasty: early assessment of wear. Clin Orthop Relat Res. 2006 453:86-90.PMID: 17312588
  41. Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM: Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-α production in response to titanium particles in vitro. J Bone Joint Surg Am. 2007 89(5):1019-27. PMID: 17473139
  42. Akhavan S, Goldberg VM: Clinical outcome of a fibermetal taper stem: minimum 5-year followup. Clin Orthop Relat Res. 2007 465:106-11. PMID: 17767076
  43. Mont MA, Seyler TM, Ulrich SD, Beaule PE, Boyd HS, Grecula MJ, Goldberg VM, Kennedy WR, Marker DR, Schmalzried TP, Sparling EA, Vail TP, Amstutz HC: Effect of changing indications and techniques on total hip resurfacing. Clin Orthop Relat Res. 2007 465:63-70. PMID: 17891034
  44. Goldberg VM: Contemporary total joint arthroplasty. N C Med J. 2007; 68(6):447-50.PMID: 18236867
  45. Garcia RM, Kraay MJ, Goldberg VM: Retention of superficially damaged femoral components after metal-backed patella component failure. J Arthroplasty. 2008 23(6):850-8.PMID: 18534531
  46. Beidelschies MA, Huang H, McMullen MR, Smith MV, Islam AS, Goldberg VM, Chen X, Nagy LE, Greenfield EM: Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. J Cell Physiol. 2008 217(3):652-66. PMID: 18651635
  47. Garcia RM, Kraay MJ, Goldberg VM: Isolated all-polyethylene patellar revisions for metal-backed patellar failure. Clin Orthop Relat Res. 2008 466(11):2784-9. PMID: 18688690
  48. Garcia RM, Kraay MJ, Conroy-Smith PA, Goldberg VM: Management of the deficient patella in revision total knee arthroplasty. Clin Orthop Relat Res. 2008 466(11):2790-7. PMID: 18712583
  49. Garcia RM, Kraay MJ, Messerschmitt PJ, Goldberg VM, Rimnac CM: Analysis of retrieved ultra-high-molecular-weight polyethylene tibial components from rotating-platform total knee arthroplasty.J Arthroplasty. 2009 24(1):131-8. PMID: 18977115
  50. McAndrew CM, Fitzgerald SJ, Kraay MJ, Goldberg VM.: Incidence of postthrombotic syndrome in patients undergoing primary total knee arthroplasty for osteoarthritis. Clin Orthop Relat Res. 2010 468(1):178-81. PMID: 19543781
  51. Hartzband MA, Glassman AH, Goldberg VM, Jordan LR, Crowninshield RD, Fricka KB, Jordan LC: Survivorship of a Low-stiffness Extensively Porous-coated Femoral Stem at 10 Years. Clin Orthop Relat Res. 2009 [Epub ahead of print]PMID: 19557489
  52. Garcia RM, Kraay MJ, Goldberg VM: Isolated Resurfacing of the Previously Unresurfaced Patella Total Knee Arthroplasty. J Arthroplasty. 2009 [Epub ahead of print] PMID: 19615851
  53. Garcia RM, Hardy BT, Kraay MJ, Goldberg VM: Revision total knee arthroplasty for aseptic and septic causes in patients with rheumatoid arthritis. Clin Orthop Relat Res. 2010 468(1):82-9.PMID: 19727993
  54. Solchaga LA, Penick K, Goldberg VM, Caplan AI, Welter JF: Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Eng Part A. 2010 16(3):1009-19 PMID: 19842915
  55. Marulanda GA, Krebs VE, Bierbaum BE, Goldberg VM, Ries M, Ulrich SD, Seyler TM, Mont MA: Hemostasis using a bipolar sealer in primary unilateral total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2009 38(12):E179-83.
  56. Goldberg VM, Goldberg L: Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis. J Pain Res. 2010 3:51-6.
  57. Furmanski J, Goldberg VM: Commentary on an article by B.H. Currier, MChE, et al.: "In vivo oxidation in remelted highly cross-linked retrievals". J Bone Joint Surg Am. 2010 92(14):e23.
  58. Wera GD, Gillespie RJ, Petty C, Petersilge WJ, Kraay MJ, Goldberg VM: Revision of hip resurfacing arthroplasty. Am J Orthop (Belle Mead NJ). 2010 39(8):E78-83.
  59. Greenfield EM, Beidelschies MA, Tatro JM, Goldberg VM, Hise AG: Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010 285(42):32378-84
  60. Fitzgerald SJ, McAndrew CM, Kraay MJ, Goldberg VM: Incidence of postthrombotic syndrome in patients undergoing primary total hip arthroplasty for osteoarthritis. Clin Orthop Relat Res. 2011 469(2):530-4.
  61. Goldberg VM, Buckwalter J, Halpin M, Jiranek W, Mihalko W, Pinzur M, Rohan B, Vail T, Walker P, Windsor R, Wright T: Recommendations of the OARSI FDA Osteoarthritis Devices Working Group. Osteoarthritis Cartilage. 2011 19(5):509-14