Study Title & Work Component
|
Sample Size
|
Performance Site
|
Status
|
| |
|
|
|
| Household Transmission of Tuberculosis
[Epidemiology] |
1,000
|
Uganda
|
Completed
|
Kawempe Community Health Study - Tuberculosis
Transmission Study [Epidemiology]
|
1,500
|
Uganda
|
Ongoing
|
| |
|
|
|
Pilot Studies (I-IX) to Assess Ex vivo Regulation of Host
Cell-mediated and Humoral Immune Responses during Short Course Anti-TB Treatment of
HIV-non-infected and HIV infected Adults [Immunology]
|
100
|
Uganda
|
Ongoing
|
Immunologic Correlates of
Host Susceptibility to M. tuberculosis Infection and Progression to
Active TB in Household Contacts of Patients with Sputum Smear Positive
Tuberculosis [Immunology]
|
1,000
|
Uganda
|
Ongoing
|
Pilot Study to Assess Immunologic and
Microbiologic Predictors of Response to Short Course Anti-TB Treatment
in HIV-non-infected Adults with Initial Episodes of Smear Positive
Pulmonary Tuberculosis [Immunology/Microbiology]
|
80
|
Brazil
|
Ongoing
|
Immunopathogenesis and Role of Apoptosis
in Tuberculous Pleurisy [Immunology]
|
60
|
Uganda
|
Ongoing
|
Immune Response to BCG Vaccination in
HIV-infected Newborns
|
260
|
South Africa
|
Ongoing
|
| |
|
|
|
Pilot Studies of the Utility of New Surrogate
Microbial Markers to Assess in vivo Antimicrobial Activity in HIV-infected
and HIV-non-infected Adults with Pulmonary TB Receiving Standard Short
Course Therapy [Microbiology]
|
79
|
Brazil, New York, Uganda
|
Completed
|
| |
|
|
|
Phase I/II Study of the Safety and Microbiologic
and Immunologic Activity of Heat-killed M. vaccae Immunotherapeutic
Agent as an Adjunct to Standard Chemotherapy for the Initial Treatment
of Pulmonary TB in HIV-non-infected Adults [Clinical Trials]
|
20
|
Uganda
|
Completed
|
An Open Label Multiple Doses Study of
the Safety and the Early Bactericidal Activity of KRM-1648 in the
Treatment of Newly Diagnosed Adults with Smear-Positive Tuberculosis
[Clinical Trials]
|
60
|
Brazil
|
Completed
|
Phase II Randomized, Placebo-Controlled
Trial of the Safety and Preliminary Evidence for Microbiologic and
Immunologic Activity of Recombinant Human IL-2 (Proleukin) in HIV-non-infected
Adults with Pulmonary TB [Clinical Trials]
|
110
|
Uganda
|
Completed
|
Phase III Study of Shortening the Duration
of Standard Short Course Chemotherapy from 6 Months to 4 Months in
HIV-non-infected Adults with Non-cavitary Tuberculosis Who Convert
Their Sputum Cultures to Negative after 2 Months of Treatment [Clinical
Trials]
|
758
|
Brazil, Philippines, Uganda
|
Ongoing
|
Phase I Study of the Early Bactericidal
Qctivity of Linezolid and Moxifloxacin in HIV-non-infected Adults
with Initial Episodes of Smear Positive Tuberculosis [Clinical Trials]
|
70
|
Brazil
|
Ongoing
|
