Roxana E. Rojas, M.D., Ph.D.
Instructor
Education
M.D., Ph.D.-University of La Plata, School of Medicine, Argentina
Office Biomedical Research Building 1010B
Lab Biomedical Research Building 1010B
Email rxr38@case.edu
Research Area
Immunology Tuberculosis
Research
I have been working in Dr W. H. Boom’s laboratory for
the past 5 years. The main focus of our laboratory is to study
antigen processing and presentation for different T cell subtypes,
i.e. CD4+, CD8+ and T cells, in M. tuberculosis infection. We
are interested in the role of different M. tuberculosis components
in regulation of the antigen processing and presentation machinery.
More recently we became interested in exploring direct modulation
of T cell function by M. tuberculosis components.
Selected Publications
• R. E. Rojas, Balaji K. N., Subramanian A. and Boom
W. H. 1999.
Regulation of human CD4+áâ T-cell-receptor-positive
(TCR+) and ãä TCR+ T-cell responses to Mycobacterium
tuberculosis by Interleukin-10 and Transforming growth factor-â.
Infection and Immunity. 67 (12): 6461-6472.
• R. E, Rojas and W. H. Boom.
Gamma-delta T cells in HIV-1 infection. Cytometric Cellular
Analysis series. 2001 by Wiley- Liss Inc., pp 147- 205.
• R. E. Rojas, M. Torres, J.J. Fournie, C.Harding and
W.H. Boom. 2002.
Phosphoantigen presentation by macrophages to Mycobacterium
tuberculosis- reactive V 9V 2 T cells: modulation by chloroquine.
Infection and Immunity, 70, (8): 4019-4027.
• A. Gehring, R. E. Rojas*, C. Harding and W. H. Boom.
2003.
The 19kD lipoprotein of Mycobacterium tuberculosis inhibits
on antigen processing and presentation by human monocytes Infection
and Immunity, 71, (8): 4487– 4497. * Shared first authorship.
