Roland W. Moskowitz, M.D.
Professor of Medicine, Case
Education:
M.D. - 1953 - Temple University School of Medicine - Medicine
M.S. - 1960 - University of Minnesota - Medicine
Professional Training:
1955 & 1960 - Fellowship in Internal Medicine/Rheumatic Diseases - Mayo Clinic
Honors:
Alpha Omega Alpha; Central Research Society; American Federation for Clinical Research;
Orthopaedic Research Society; American Rheumatism Association.
Academic Appointments:
1960-1962 - Instructor in Medicine; Temple University.
1962 - Chief of Rheumatology Service, Division B; Philadelphia General Hospital.
1962 - Senior Instructor of Medicine; Western Reserve University.
1965 - Assistant Professor of Medicine; University Hospitals of Cleveland (UH).
1971 - Associate Professor of Medicine; Case Western Reserve University School of Medicine.
1976 - Professor of Medicine; Case Western Reserve University (CWRU).
1976 - Director, Division of Rheumatic Diseases; CWRU/UH.
1978 - Director, Northeast Ohio Multipurpose Arthritis Center (NIH)
2002 - Co-Director, Arthritis Translational Research Program (CWRU/UHRI)
Representative Publications: (from a total of 207)
1. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum 30:87-89, 2000.
2. Ah-Kim H, Zhang X, Islam S, Sofi JI, Glickberg Y, Malemud CJ, Moskowitz RW, Haqqi TM. Tumor necrosis factor-α enhances the expression of hydroxyl lyase, cytoplasmic antiproteinase-2 and a dual specificity kinase TTK in HTB-94 cells and human chondrocytes: identification by differential display analysis of mRNAs. Cytokine 12:142-150, 2000.
3. Islam S, Islam N, Kermode T, Johnstone B, Mukhtar H, Moskowitz RW, Goldberg VW, Malemud CJ, Haqqi TM. Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells. Biochem Biophys Res Commun 270:793-797, 2000.
4. Moskowitz, RW, Altman RD. Efficacy of intraarticular hyaluronans in the treatment of knee osteoarthritis: comment on the article by Brandt et al. Arthritis Rheum 44:1471-1476, 2001.
5. Moskowitz RW. Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs. J Rheumatol 28:932-934, 2001.
6. Islam S, Kermode T, Sultana D, Moskowitz RW, Mukhtar H, Malemud C, Goldberg VM, Haqqi TM. Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes. Osteoarthritis and Cart, 2001; 9:684-693.
7. Mier RJ, Holderbaum D, Ferguson R, Moskowitz, R. Osteoarthritis in children associated with a mutation in the type II procollagen gene (COL2A1). Mol Genet Metab 2001;74:338-341.
8. Ciesielski CJ, Holderbaum D, Moskowitz RW, Carson DA, Corr M. Single nucleotide polymorphisms in FRZB in Hereditary Chondrolysis Syndrome. Arthritis Rheum 2002; 46:S274.
9. Pincus T, Fort JG, Koch G, Wolfe F, Moskowitz R, Zlotnick S, Simon L, Gibofsky A, Lei H, Schuller R. Preference of patients with osteoarthritis of the hip or knee for celecoxib versus acetaminophen and placebo in a randomized, double-blind, cross-over clinical trial. Arth Rheum 2002; 46: 851-854.
10. Moskowitz RW, Sunshine A, Brugger A, Lefkowith JB, Zhao WW, Geis GS. The American Pain Society (APS) pain questionnaire in the assessment of osteoarthritis pain: a pooled analysis of three celecoxib pivotal studies. Am J Ther 2003;10:12-20.
11. Pincus T, Koch G, Mangal B, Sokka T, Moskowitz R, Wolfe F, Gibofsky A, Simon L, Zlotnick S, Fort JG. Patient preference for placebo, acetaminophen (paracetamol) or celecoxib efficacy studies (PACES): two randomized, double blind, placebo controlled, crossover clinical trials with knee or hip osteoarthritis. Ann Rheum Dis 2004; 63:931-939.
12. Moskowitz RW, Kelly MA, Lewallen DG, Vangsness Jr, TV. Nonsurgical approaches to pain management for osteoarthritis of the
knee. Am J Orthop 2004;33S:10-14.
Research Projects Ongoing or Completed in the Last 3 Years:
Current/Ongoing Projects:
5T32 AR07505-15 (Moskowitz) - 05/01/01-04/30/06 - 0%
NIH - $127,873
Training Program in Musculoskeletal Research
Postdoctoral Training Support
RO1 AR46277 (Moskowitz) - 04/01/01-3/31/05 - 10%
NIH - $150,000
Genetic Mutations as Etiologic Factors in Osteoarthritis
The major goal of this project is to define mutations related to primary osteoarthritis in well-defined families with precocious generalized OA.
Investigator Initiated Grant (Moskowitz) - 1/15/04-7/15/05 - 10%
GlaxoSmithKline - $165,059
Development and Validation of an Assessment Instrument to Quantify Total OA Load (TQOL)
(Hooper/Moskowitz) - 7/1/03-6/30/04 - 10%
Pfizer - $122,024
Pilot Study of an Acute Pain Model in Osteoarthritis, Phase I and II
(The Moskowitz/Sunshine Pain Model)
Contract (Moskowitz) - 1/1/04-12/31/05 - 5%
GlaxoSmithKline - $217,000
Genetics of Generalized Osteoarthritis Extension Study
(Hooper/Moskowitz) - 1/1/03-12/31/05 - 15%
Prentiss Foundation - $100,000
Osteoarthritis and Osteoporosis: The Impact of Weight and Gastric Bypass-Facilitated Weight Loss
The major goal of this project is to understand the basic relationships between weight, knee osteoarthritis and between gastric bypass surgery and osteoporosis, as well as aid in improving diagnostic and therapeutic approaches to these issues.
Contract AR92236 (Hooper/Moskowitz) - 09/15/99-09/14/04 - 5% (no salary)
NIH - $65,000
Study of the Efficacy of Glucosamine and Chondroitin Sulfate in Osteoarthritis of the Knee
The major goal of this project is to perform a collaborative study of glucosamine-chondroitin sulfate in the treatment of OA.
Completed Projects:
Contract (Moskowitz) - 07/01/99-06/30/03 - 15%
Glaxo-Wellcome - $282,225
Genetics of Generalized Osteoarthritis (GOGO)
The major goal of this collaborative study is to examine sib-pair genetics for the study of OA.
5P60 AR20618-22 (Moskowitz) - 09/15/98-06/30/03 - 22.5%
NIH/NIAMS - $682,806
Northeast Ohio Multipurpose Arthritis and Musculoskeletal Diseases Center
A comprehensive center for funding of research and demonstration projects in basic science, musculoskeletal disease, and health services/education/epidemiology research.
5RO1 AR45687-03 (Warman) - 05/01/98-04/30/02 - 10%
NIH/NIAMS SCOR - $142,542
Genetics of Joint Failure
The major goals of this project are to collect a cohort of well-characterized affecting sibling pairs who have undergone joint replacement surgery for osteoarthritis as a prelude toward distinguishing between genetic and environmental components of risk and the genetic mapping of osteoarthritis predisposing loci.
AF (Moskowitz) - 07/01/99-06/30/02 - 10%
Arthritis Foundation - $83,333
Genetics of Osteoarthritis
The major goal of this project is to study mechanisms associated with genetically-related primary osteoarthritis, primarily utilizing candidate gene analyses.
525-Y6 (Moskowitz) - 07/01/00-06/30/01 - 5%
Ohio Department of Health - $22,100
Arthritis Fellowship Support
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