Charles J. Malemud, Ph.D.
Professor of Medicine and Anatomy
Education:
Ph.D. - 1969-1973 - George Washington University, Washington, D.C. - Pathology
1966-1968 - Long Island University Graduate School of Arts & Sciences- Biology
B.S. - 1962-1966 - Long Island University, Brooklyn, NY - Biology
Postdoctoral Education:
1973-1974 - State University of New York, Stony Brook, NY - Pathology
Appointments at Case Western Reserve University:
1994-2000 - Coordinator, Core Academic Program (CAP), School of Medicine
2000 - Liaison to Curriculum Leadership Council (CLC), School of Medicine
1994-2000 - Vice-Chair, Committee on Medical Education (CME), School of Medicine
2000-2001 - Educational Consultant and Associate Coordinator, Flexible (Electives) Program, School of Medicine
2001 - Co-Coordinator, Flexible (Electives) Program, School of Medicine
2002-2003 - Coordinator, Flexible (Electives) Program, School of Medicine
2001-2002 - Co-Chair, Flexible Program Advisory Committee, School of Medicine
2002-2003 - Chair, Flexible Program Council and Member of the Academic Cabinet, School of Medicine
2002-2003 - Voting Member, CME
Appointments at University Hospitals of Cleveland:
1978-2001 - Member, Rheumatology Fellow Selection Committee, Department of Medicine,
Division of Rheumatic Diseases
1981-1998 - Director of Research, Division of Rheumatic Diseases
2000-2004 - Scientific Staff, The Research Institute of University Hospitals of Cleveland†
2001-present - Associate Director, Rheumatology Fellowship Program
2001-present - Member, Rheumatology Fellowship Executive Committee
2002-present - Member, Division of Rheumatic Diseases Executive Committee
Honors and Awards:
1998-1999 - American Men and Women of Science
2001 - Nominated, “Best of Science”
2004 - Who’s Who in Medicine and Healthcare, 5th Edition
2004 - American Men and Women of Science, 22nd Edition
NIH Grants:
1980-1994 - PRINCIPAL INVESTIGATOR, National Institute on Aging, AG-02205, Behavior of Human Cartilage
1994-1995 - PRINCIPAL INVESTIGATOR, National Institute on Aging, AG-10418 (POAIC subproject), Type X Collagen Transcription as a Marker for Human Osteoarthritis
1978-1981 - CO-INVESTIGATOR, National Institute on Aging, AG-01305, Pathogenesis and Therapy of Experimental Osteoarthritis
1981-1996 - CO-INVESTIGATOR, NIAMS, AR-30134, Pathogenesis and Therapy of Experimental Osteoarthritis
1981-1998 - DIRECTOR OF BIOMEDICAL RESEARCH, NIAMS, AR-20618, Multipurpose Arthritis Center
2002-2007 - CO-INVESTIGATOR, NIAMS, AR-48782-02, Prevention of Cartilage Degradation by Green Tea
2004-2009 - PRINCIPAL INVESTIGATOR, NIAMS, AR-51115-01A1, Cartilage Apoptosis in Aging and Osteoarthritis (11/04)
Publications:
1. Ganu VS, Hu S-I, Melton R, Winter C, Goldberg VM, Haqqi TM, Malemud CJ:
Biochemical and molecular characterization of stromelysin synthesized by
human osteoarthritic chondrocytes stimulated with recombinant human
interleukin-1. Clin Exp Rheumatol (1994) 12: 489-96.
2. Malemud CJ, Goldberg VM: Synthesis of aggrecan core proteins by human
cartilage and chondrocytes in vitro. J Rheumatol (1995) 22 (Suppl 43): 9-13.
3. Malemud CJ, Papay RS, Hering TM, Holderbaum D, Goldberg VM, Haqqi TM:
Phenotypic modulation of newly synthesized proteoglycans in human cartilage
and chondrocytes. Osteoarthritis Cartilage (1995) 3: 227-38.
4. Palmer JL, Bertone AL, Mansour J, Carter BG, Malemud CJ: Biomechanical
properties of third carpal cartilage in exercised and nonexercised horses. J
Orthop Res (1995) 13: 854-60.
5. Palmer JL. Bertone AL, Malemud CJ, Carter BG, Papay RS, Mansour J: Site-
specific proteoglycan characteristics of third carpal articular cartilage in exercised
and nonexercised horses. Am J Vet Res (1995) 56: 1570-76.
6. Palmer JL, Bertone AL, Malemud CJ, Mansour J: Biochemical and
biomechanical alterations in equine articular cartilage following an
experimentally-induced synovitis. Osteoarthritis Cartilage (1996) 4: 127-37.
7. Malemud CJ, Papay RS, Hering TM: Forskolin stimulates aggrecan gene expression in cultured bovine chondrocytes. Am J Therapeut (1996) 3: 120-8.
8. Canning DR, Höke A, Malemud CJ, Silver J. A potent inhibitor of neurite outgrowth that predominates in the extracellular matrix of reactive astrocytes. Int J Dev Neurosci (1996) 14: 153-75.
9. Lillich JD, Bertone AL, Malemud CJ, Weisbrode SE, Ruggles AJ, Stevenson SS: Biochemical, histochemical and immunohistochemical characterization of distal
tibial osteochondrosis in horses. Am J Vet Res (1997) 58: 89-98.
10. Hardy J, Bertone AL, Malemud CJ: Effect of synovial membrane infection in vitro on equine synoviocytes and chondrocytes. Am J Vet Res (1998) 59: 293-99.
11. Palmer JL, Bertone AL, Malemud CJ, Mansour J: Changes in third carpal bone articular cartilage after synovectomy in normal and inflamed joints. Vet Surg (1998) 27: 321-30.
12. Malemud CJ: (Editor) Fundamental Pathways in Osteoarthritis. Front Biosci (1999) 4: d659-771.
13. Malemud CJ: Fundamental pathways in osteoarthritis: an overview. Front Biosci (1999) 4: d659-61.
14. Malemud CJ, Goldberg VM: Directions for future research and treatment of
osteoarthritis. Front Biosci (1999) 4:d762-71.
15. Denko CW, Malemud CJ: Metabolic disturbances in synovial joint responses in osteoarthritis. Front Biosci (1999) 4: d689-94.
16. Haqqi TM, Anthony DD, Malemud CJ: Chondrocytes. In: Principles of Molecular
Rheumatology. GC Tsokos, Editor, Humana Press, Totowa (2000) pp. 267-77.
17. Ah-Kim H, Zhang X, Islam S, Sofi JI, Glickberg Y, Malemud CJ, Moskowitz RW,
Haqqi TM: Tumor necrosis factor-á enhances expression of hydroxyl lyase,
cytoplasmic antiproteinase-2, and a dual specificity TTK in human chondrocyte-
like cells. Cytokine (2000) 12: 142-50.
18. Islam S, Islam N, Kermode T, Johnstone B, Mukhtar H, Moskowitz RW,
Goldberg VM, Malemud CJ, Haqqi TM: Involvement of caspase-3 in
epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells.
Biochem Biophys Res Commun (2000) 270: 793-7.
19. Islam S, Kermode T, Sultana D, Moskowitz RW, Mukhtar H, Malemud CJ, Goldberg VM, Haqqi TM: Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes. Osteoarthritis Cartilage (2001) 9: 684-93.
20. Denko CW, Boja B, Malemud CJ: Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH). Front Biosci (2002) 7: a37-43.
21. Islam N, Haqqi TM, Jepsen KJ, Kraay M, Welter JF, Goldberg VM, Malemud CJ: Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-á, inducible
nitric oxide synthase, p53, c-myc and bax-á and suppression of bcl-2. J Cell Biochem (2002) 87: 266-78.
22. Denko CW, Boja B, Malemud CJ: Intra-erythrocyte deposition of growth hormone in rheumatic diseases. Rheumatol Int (2003) 23: 11-4.
23. Singh R, Ahmed S, Malemud CJ, Goldberg VM, Haqqi TM: Epigallocatechin-3- gallate selectively inhibits interleukin-1â-induced activation of mitogen-activated protein kinase subgroup c-Jun-N-terminal kinase in human osteoarthritis
chondrocytes. J Orthop Res (2003) 21: 102-9.
24. Malemud CJ, Islam N, Haqqi TM: Pathophysiologic mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs (2003) 174: 34-48.
25. Malemud CJ: Cytokines as therapeutic targets for osteoarthritis. BioDrugs (2004) 18: 23-35.
26. Denko CW, Malemud CJ: The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients. Front Biosci (2004) 9: 1660- 1664.
27. Palmer JL, Mansour J, Malemud CJ, Bertone AL: Effects of intra-articular hyaluronic acid on ex vivo responses by third carpal bone cartilage from horses with experimentally-induced synovitis. Equine Comp Exercise Physiol
(2004) 1:119-129.
28. Denko CW, Malemud CJ: Serum growth hormone and insulin, but not insulin-like growth factor-1 are elevated in patients with fibromyalgia syndrome. Rheumatol Int (2004) in press
29. Malemud CJ: Protein kinases in chondrocyte signaling and osteoarthritis. Clin Orthop Relat Res (2004) in press
Research Support:
Active:
RO1-AR48792-01 TM Haqqi, Principal Investigator, 5/1/02 - 4/30/07
Prevention of Cartilage Degradation by Green Tea
Role: Co-investigator
A biologically active polyphenolic fraction of green tea, epigallocatechin-3-gallate is employed to
inhibit human chondrocyte MMP synthesis.
Role: Principal Investigator: Charles J. Malemud, Ph.D.
Leslie Newton Fund (Department of Orthodontics, Case Western Reserve University)
MG Hans, CJ Malemud, Co-Principal Investigators 6/1/03-5/30/05
Tissue Engineering of Temporomandibular Joint Cartilage
Cartilage-constructs are prepared from mandibular condyle cartilage and disc cells of the
temporomandibular joint.
Completed:
P60 AR20618-25, RW Moskowitz, Principal Investigator, 6/1/97-5/30/02
Multipurpose Arthritis Center
Role: Administrative Core Consultant
A comprehensive basic and health services musculoskeletal and arthritis research center.
Nutramax Laboratories (Edgewood, MD) CJ Malemud, Principal Investigator, 11/20/01-12/31/03
Effect of Dietary Chondroprotective Supplements on Proteoglycan and Collagen Degradation in
Human Immortalized Chondrocytes
Glucosamine and chondroitin sulfate compounds are employed to alter matrix metalloproteinase
(MMP) gene transcription.
